# Therapeutics and medical devices ETFs > ETFIQ covers 5 therapeutics and medical devices ETFs. The largest are IHI ($3.6bn) and CANC ($209m); fees run 0.37% to 1.00%, as of Oct 26 to 27, 2026. Data as of Oct 27, 2026. Rebuilt every trading night. Data as of Oct 27, 2026 . ## Therapeutics and medical devices ETFs See every therapeutics and medical devices ETF by what it holds, not by its name. Funds that hold drug developers and medical device makers, usually in one field such as oncology, neuroscience or vaccines. 5 funds, largest first. Updated Oct 27, 2026. The typical fund carries 21% of its weight in S&P 500 stocks, the 34th most of the 53 themes with holdings on file. 5 US listed therapeutics and medical devices ETFs $3.6bn The largest, IHI 0.37% The cheapest, IHI +35.4% Best one year, CANC ### The short answers Least like the S&P 500 IBRN , iShares Neuroscience and Healthcare ETF, 5.6% of its weight in S&P 500 companies. Closest pair IHI and MDEV , 32% of their weight in the same companies. ### What these funds actually own Between them the 5 funds' ten largest holdings name 45 companies, of which 5 appear in more than one. ALKERMES PLC is among the ten largest of 2 of them, at an average of 4.5% of the fund. | Company | Among the ten largest of | Average weight where it is | Largest, and in which fund | | --- | --- | --- | --- | | ALKERMES PLC ALKS | 2 of 5 | 4.5% | 4.7% in IBRN | | NEUROCRINE BIOSCIENCES INC NBIX | 2 of 5 | 4.5% | 4.6% in IBRN | | RESMED RMD | 2 of 5 | 3.4% | 4.8% in IHI | | STRYKER SYK | 2 of 5 | 3.4% | 4.7% in IHI | | GE HEALTHCARE TECHNOLOGIES GEHC | 2 of 5 | 3.2% | 4.2% in IHI | | ABBOTT LABORATORIES ABT | 1 of 5 | 17.6% | 17.6% in IHI | | INTUITIVE SURGICAL ISRG | 1 of 5 | 15.5% | 15.5% in IHI | | DEFINIUM THERAPEUTICS INC DFTX | 1 of 5 | 12.8% | 12.8% in PSIL | | COMPASS PATHWAYS PLC CMPS | 1 of 5 | 11.4% | 11.4% in PSIL | | MEDTRONIC PLC MDT | 1 of 5 | 11.3% | 11.3% in IHI | | ATAIBECKLEY INC ATAI | 1 of 5 | 10.5% | 10.5% in PSIL | | RELMADA THERAPEUTICS INC RLMD | 1 of 5 | 6.8% | 6.8% in PSIL | | NRX PHARMACEUTICALS INC NRXP | 1 of 5 | 6.1% | 6.1% in PSIL | | BIOGEN BIIB | 1 of 5 | 5.6% | 5.6% in IBRN | | REVOLUTION MEDICINES INC RVMD | 1 of 5 | 5.2% | 5.2% in CANC | The 15 most widely held of 45. Each row counts the ten largest holdings of each fund, so a fund missing from a row may still hold that company lower down. Weights are of the funds that name it, not of the theme. ### The 5 largest therapeutics and medical devices ETFs ETFIQ covers 5 therapeutics and medical devices ETFs. The largest are IHI ( $3.6bn ), CANC ( $209m ) and PSIL ( $46m ); fees run 0.37% to 1.00% , as of Oct 26 to 27, 2026 . - IHI iShares U.S. Medical Devices ETF $3.6bn 0.37% - CANC Tema Oncology ETF $209m 0.75% - PSIL AdvisorShares Psychedelics ETF $46m 1.00% - IBRN iShares Neuroscience and Healthcare ETF $6.3m 0.47% - MDEV First Trust Indxx Medical Devices ETF $3.3m 0.70% | Ticker | Fund | Issuer | Net assets | In the S&P 500 | Active share | Total return 1Y | vs its benchmark 1Y | Fee | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | IHI | iShares U.S. Medical Devices ETF | iShares | $3.6bn | 88.4% | 98.7% | −12.2% | not measured | 0.37% | | CANC | Tema Oncology ETF | Tema | $209m | 21.2% | 95.7% | +35.4% | not measured | 0.75% | | PSIL | AdvisorShares Psychedelics ETF | AdvisorShares | $46m | 7.8% | 98.4% | +14.2% | not measured | 1.00% | | IBRN | iShares Neuroscience and Healthcare ETF | iShares | $6.3m | 5.6% | 100.0% | +7.9% | not measured | 0.47% | | MDEV | First Trust Indxx Medical Devices ETF | First Trust | $3.3m | 47.1% | 98.0% | +4.2% | not measured | 0.70% | ### How much of each pair is the same fund The closest pair is IHI and MDEV , which hold 32% of their weight in the same companies. The furthest apart is MDEV and PSIL at 0%. The middle pair of the 10 is 0%. | | IHI | CANC | PSIL | IBRN | MDEV | | --- | --- | --- | --- | --- | --- | | IHI | · | 0% | 0% | 0% | 32% | | CANC | 0% | · | 6% | 0% | 0% | | PSIL | 0% | 6% | · | 13% | 0% | | IBRN | 0% | 0% | 13% | · | 0% | | MDEV | 32% | 0% | 0% | 0% | · | Weight overlap adds the smaller of the two weights for every company both funds hold. Funds with a cut-short book are left out, not compared short. ### What each fund holds alone | Fund | Largest holding it alone has | Weight | All of its own names | | --- | --- | --- | --- | | IHI | IDEXX LABORATORIES IDXX | 4.7% | 11.2% | | CANC | REVOLUTION MEDICINES INC RVMD | 5.2% | 93.4% | | PSIL | DEFINIUM THERAPEUTICS INC DFTX | 12.9% | 68.6% | | IBRN | BIOGEN BIIB | 5.6% | 80.0% | | MDEV | Smith & Nephew Plc SN/.LN | 2.2% | 60.3% | ### Questions people ask How many therapeutics and medical devices ETFs are there? ETFIQ covers 5 US listed therapeutics and medical devices ETFs as of Oct 27, 2026. That is every one it can measure from the fund’s own published holdings. What is the largest therapeutics and medical devices ETF? IHI , iShares U.S. Medical Devices ETF, at $3.6bn in net assets as of Oct 26, 2026, the largest of the 5 therapeutics and medical devices ETFs with a published size. What is the cheapest therapeutics and medical devices ETF? IHI , iShares U.S. Medical Devices ETF, at 0.37% a year by its prospectus filed Jul 27, 2026, the lowest fee of the 5 therapeutics and medical devices ETFs that publish one. Which therapeutics and medical devices ETF has performed best over the past year? CANC , Tema Oncology ETF, at +35.4% total return over the year to Oct 27, 2026, the highest of the 5 therapeutics and medical devices ETFs with a full year of trading behind them. Past returns do not predict future ones. What do therapeutics and medical devices ETFs hold? Funds that hold drug developers and medical device makers, usually in one field such as oncology, neuroscience or vaccines. Between them the 5 therapeutics and medical devices ETFs ETFIQ can read name 45 companies in their ten largest holdings, by holdings dated Jun 30, 2026 to Oct 26, 2026, most widely ALKERMES PLC, which is among the ten largest of 2 of them. Do therapeutics and medical devices ETFs hold the same companies? It depends which two. Across the 10 pairs of the 5 therapeutics and medical devices ETFs with a full published book, by holdings dated Jun 30, 2026 to Oct 26, 2026, IHI and MDEV hold 32% of their weight in the same companies, MDEV and PSIL hold 0%, and the middle pair holds 0%. Two funds sold on one theme are not the same fund. ### What the issuers say about this theme The issuers behind these therapeutics and medical devices funds publish their own work on this theme. These are their pages and words, not ETFIQ’s. A fund company writing about a theme it sells is making a case. | Issuer | What they publish | Kind | | --- | --- | --- | | iShares | iShares Portfolio Insights | Their research index | | Tema | Tema ETFs insights | Their research index | | First Trust | First Trust Investment Insights | Their research index | ### Where to next ### Sources Links are sources, not endorsements. ETFIQ is an independent publisher and makes no recommendations. Standards and sources --- Source: ETFIQ, independent ETF data. Recomputed nightly from public filings and prices. Cite: ETFIQ, Therapeutics and medical devices ETFs, data as of Oct 27, 2026. https://etfiq.com/themes/therapeutics Licence: https://etfiq.com/license/ Data ETFIQ computes is free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms. HTML: https://etfiq.com/themes/therapeutics