{"url":"https://etfiq.com/themes/therapeutics","section":"themes","title":"Therapeutics and medical devices ETFs | ETFIQ","description":"ETFIQ covers 5 therapeutics and medical devices ETFs. The largest are IHI ($3.6bn) and CANC ($209m); fees run 0.37% to 1.00%, as of Oct 26 to 27, 2026.","as_of":"Oct 27, 2026","structured_data":[{"@type":"FAQPage","mainEntity":[{"@type":"Question","name":"How many therapeutics and medical devices ETFs are there?","acceptedAnswer":{"@type":"Answer","text":"ETFIQ covers 5 US listed therapeutics and medical devices ETFs as of Oct 27, 2026. That is every one it can measure from the fund\u2019s own published holdings."}},{"@type":"Question","name":"What is the largest therapeutics and medical devices ETF?","acceptedAnswer":{"@type":"Answer","text":"IHI, iShares U.S. Medical Devices ETF, at $3.6bn in net assets as of Oct 26, 2026, the largest of the 5 therapeutics and medical devices ETFs with a published size."}},{"@type":"Question","name":"What is the cheapest therapeutics and medical devices ETF?","acceptedAnswer":{"@type":"Answer","text":"IHI, iShares U.S. Medical Devices ETF, at 0.37% a year by its prospectus filed Jul 27, 2026, the lowest fee of the 5 therapeutics and medical devices ETFs that publish one."}},{"@type":"Question","name":"Which therapeutics and medical devices ETF has performed best over the past year?","acceptedAnswer":{"@type":"Answer","text":"CANC, Tema Oncology ETF, at +35.4% total return over the year to Oct 27, 2026, the highest of the 5 therapeutics and medical devices ETFs with a full year of trading behind them. Past returns do not predict future ones."}},{"@type":"Question","name":"What do therapeutics and medical devices ETFs hold?","acceptedAnswer":{"@type":"Answer","text":"Funds that hold drug developers and medical device makers, usually in one field such as oncology, neuroscience or vaccines. Between them the 5 therapeutics and medical devices ETFs ETFIQ can read name 45 companies in their ten largest holdings, by holdings dated Jun 30, 2026 to Oct 26, 2026, most widely ALKERMES PLC, which is among the ten largest of 2 of them."}},{"@type":"Question","name":"Do therapeutics and medical devices ETFs hold the same companies?","acceptedAnswer":{"@type":"Answer","text":"It depends which two. Across the 10 pairs of the 5 therapeutics and medical devices ETFs with a full published book, by holdings dated Jun 30, 2026 to Oct 26, 2026, IHI and MDEV hold 32% of their weight in the same companies, MDEV and PSIL hold 0%, and the middle pair holds 0%. Two funds sold on one theme are not the same fund."}}]},{"@type":"ItemList","name":"Therapeutics and medical devices ETFs","numberOfItems":5,"itemListElement":[{"@type":"ListItem","position":1,"name":"IHI","url":"https://etfiq.com/funds/ihi"},{"@type":"ListItem","position":2,"name":"CANC","url":"https://etfiq.com/funds/canc"},{"@type":"ListItem","position":3,"name":"PSIL","url":"https://etfiq.com/funds/psil"},{"@type":"ListItem","position":4,"name":"IBRN","url":"https://etfiq.com/funds/ibrn"},{"@type":"ListItem","position":5,"name":"MDEV","url":"https://etfiq.com/funds/mdev"}]},{"@type":"ItemList","name":"The 5 largest therapeutics and medical devices ETFs","itemListOrder":"https://schema.org/ItemListOrderDescending","numberOfItems":5,"itemListElement":[{"@type":"ListItem","position":1,"name":"IHI","url":"https://etfiq.com/funds/ihi"},{"@type":"ListItem","position":2,"name":"CANC","url":"https://etfiq.com/funds/canc"},{"@type":"ListItem","position":3,"name":"PSIL","url":"https://etfiq.com/funds/psil"},{"@type":"ListItem","position":4,"name":"IBRN","url":"https://etfiq.com/funds/ibrn"},{"@type":"ListItem","position":5,"name":"MDEV","url":"https://etfiq.com/funds/mdev"}]},{"@type":"Dataset","name":"Therapeutics and medical devices ETFs","description":"ETFIQ covers 5 therapeutics and medical devices ETFs. The largest are IHI ($3.6bn) and CANC ($209m); fees run 0.37% to 1.00%, as of Oct 26 to 27, 2026.","url":"https://etfiq.com/themes/therapeutics","dateModified":"2026-10-27","inLanguage":"en","creator":{"@id":"https://etfiq.com/#org"},"publisher":{"@id":"https://etfiq.com/#org"},"license":"https://etfiq.com/license/","isAccessibleForFree":true,"creativeWorkStatus":"Published","distribution":[{"@type":"DataDownload","encodingFormat":"application/json","contentUrl":"https://etfiq.com/data/thematic.json"}],"variableMeasured":["Weight overlap with the S&P 500","Active share","Holdings","Top ten share of the fund","Total return","Fee for the differing part","Expense ratio"],"keywords":["exchange-traded funds","ETF","Thematic ETFs","fund data","SEC filings"]},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"ETFIQ","item":"https://etfiq.com/"},{"@type":"ListItem","position":2,"name":"Thematic ETFs","item":"https://etfiq.com/themes/"},{"@type":"ListItem","position":3,"name":"Therapeutics and medical devices","item":"https://etfiq.com/themes/therapeutics"}]},{"@type":"WebPage","name":"Therapeutics and medical devices ETFs","description":"ETFIQ covers 5 therapeutics and medical devices ETFs. The largest are IHI ($3.6bn) and CANC ($209m); fees run 0.37% to 1.00%, as of Oct 26 to 27, 2026.","url":"https://etfiq.com/themes/therapeutics","dateModified":"2026-10-27","isPartOf":{"@type":"WebSite","name":"ETFIQ","url":"https://etfiq.com"},"speakable":{"@type":"SpeakableSpecification","cssSelector":[".lede",".faq"]},"publisher":{"@id":"https://etfiq.com/#org"}}],"characters":8261,"truncated":false,"content":"ETFIQ / Thematic ETFs / Therapeutics and medical devices \n \n Data as of Oct 27, 2026 .\n Therapeutics and medical devices ETFs\n See every therapeutics and medical devices ETF by what it holds, not by its name. Funds that hold drug developers and medical device makers, usually in one field such as oncology, neuroscience or vaccines. 5 funds, largest first. Updated Oct 27, 2026. The typical fund carries 21% of its weight in S&P 500 stocks, the 34th most of the 53 themes with holdings on file.\n 5 US listed therapeutics and medical devices ETFs \n $3.6bn The largest, IHI \n 0.37% The cheapest, IHI \n +35.4% Best one year, CANC \n\n The short answers\n Least like the S&P 500 IBRN , iShares Neuroscience and Healthcare ETF, 5.6% of its weight in S&P 500 companies. Closest pair IHI and MDEV , 32% of their weight in the same companies. What these funds actually own\n Between them the 5 funds' ten largest holdings name 45 companies, of which 5 appear in more than one. ALKERMES PLC is among the ten largest of 2 of them, at an average of 4.5% of the fund.\n Therapeutics and medical devices ETFs, the companies their ten largest holdings name. Source: each fund's latest SEC filing or its issuer\u2019s own daily holdings file, read by ETFIQ. Company Among the ten largest of Average weight where it is Largest, and in which fund \n ALKERMES PLC ALKS 2 of 5 4.5% 4.7% in IBRN \n NEUROCRINE BIOSCIENCES INC NBIX 2 of 5 4.5% 4.6% in IBRN \n RESMED RMD 2 of 5 3.4% 4.8% in IHI \n STRYKER SYK 2 of 5 3.4% 4.7% in IHI \n GE HEALTHCARE TECHNOLOGIES GEHC 2 of 5 3.2% 4.2% in IHI \n ABBOTT LABORATORIES ABT 1 of 5 17.6% 17.6% in IHI \n INTUITIVE SURGICAL ISRG 1 of 5 15.5% 15.5% in IHI \n DEFINIUM THERAPEUTICS INC DFTX 1 of 5 12.8% 12.8% in PSIL \n COMPASS PATHWAYS PLC CMPS 1 of 5 11.4% 11.4% in PSIL \n MEDTRONIC PLC MDT 1 of 5 11.3% 11.3% in IHI \n ATAIBECKLEY INC ATAI 1 of 5 10.5% 10.5% in PSIL \n RELMADA THERAPEUTICS INC RLMD 1 of 5 6.8% 6.8% in PSIL \n NRX PHARMACEUTICALS INC NRXP 1 of 5 6.1% 6.1% in PSIL \n BIOGEN BIIB 1 of 5 5.6% 5.6% in IBRN \n REVOLUTION MEDICINES INC RVMD 1 of 5 5.2% 5.2% in CANC \n \n The 15 most widely held of 45. Each row counts the ten largest holdings of each fund, so a fund missing from a row may still hold that company lower down. Weights are of the funds that name it, not of the theme.\n The 5 largest therapeutics and medical devices ETFs\n ETFIQ covers 5 therapeutics and medical devices ETFs. The largest are IHI ( $3.6bn ), CANC ( $209m ) and PSIL ( $46m ); fees run 0.37% to 1.00% , as of Oct 26 to 27, 2026 .\n IHI iShares U.S. Medical Devices ETF $3.6bn 0.37% \n CANC Tema Oncology ETF $209m 0.75% \n PSIL AdvisorShares Psychedelics ETF $46m 1.00% \n IBRN iShares Neuroscience and Healthcare ETF $6.3m 0.47% \n MDEV First Trust Indxx Medical Devices ETF $3.3m 0.70% \n \n Therapeutics and medical devices ETFs, as of Oct 27, 2026. Source: ETFIQ. Ticker Fund Issuer Net assets In the S&P 500 Active share Total return 1Y vs its benchmark 1Y Fee \n IHI iShares U.S. Medical Devices ETF iShares $3.6bn 88.4% 98.7% \u221212.2% not measured 0.37% \n CANC Tema Oncology ETF Tema $209m 21.2% 95.7% +35.4% not measured 0.75% \n PSIL AdvisorShares Psychedelics ETF AdvisorShares $46m 7.8% 98.4% +14.2% not measured 1.00% \n IBRN iShares Neuroscience and Healthcare ETF iShares $6.3m 5.6% 100.0% +7.9% not measured 0.47% \n MDEV First Trust Indxx Medical Devices ETF First Trust $3.3m 47.1% 98.0% +4.2% not measured 0.70% \n \n How much of each pair is the same fund\n The closest pair is IHI and MDEV , which hold 32% of their weight in the same companies. The furthest apart is MDEV and PSIL at 0%. The middle pair of the 10 is 0%.\n Therapeutics and medical devices ETFs, the share of each pair\u2019s weight held in the same companies. Read across or down; the number is the same either way. Cells are shaded against the closest pair here, 32%. Source: each fund\u2019s own filed or daily holdings, read by ETFIQ. IHI CANC PSIL IBRN MDEV \n IHI \u00b7 0% 0% 0% 32% \n CANC 0% \u00b7 6% 0% 0% \n PSIL 0% 6% \u00b7 13% 0% \n IBRN 0% 0% 13% \u00b7 0% \n MDEV 32% 0% 0% 0% \u00b7 \n \n Weight overlap adds the smaller of the two weights for every company both funds hold. Funds with a cut-short book are left out, not compared short.\n What each fund holds alone\n Therapeutics and medical devices ETFs, the largest holding no other fund in the grid holds. Source: ETFIQ. Fund Largest holding it alone has Weight All of its own names \n IHI IDEXX LABORATORIES IDXX 4.7% 11.2% \n CANC REVOLUTION MEDICINES INC RVMD 5.2% 93.4% \n PSIL DEFINIUM THERAPEUTICS INC DFTX 12.9% 68.6% \n IBRN BIOGEN BIIB 5.6% 80.0% \n MDEV Smith & Nephew Plc SN/.LN 2.2% 60.3% \n \n Questions people ask\n How many therapeutics and medical devices ETFs are there? ETFIQ covers 5 US listed therapeutics and medical devices ETFs as of Oct 27, 2026. That is every one it can measure from the fund\u2019s own published holdings. What is the largest therapeutics and medical devices ETF? IHI , iShares U.S. Medical Devices ETF, at $3.6bn in net assets as of Oct 26, 2026, the largest of the 5 therapeutics and medical devices ETFs with a published size. What is the cheapest therapeutics and medical devices ETF? IHI , iShares U.S. Medical Devices ETF, at 0.37% a year by its prospectus filed Jul 27, 2026, the lowest fee of the 5 therapeutics and medical devices ETFs that publish one. Which therapeutics and medical devices ETF has performed best over the past year? CANC , Tema Oncology ETF, at +35.4% total return over the year to Oct 27, 2026, the highest of the 5 therapeutics and medical devices ETFs with a full year of trading behind them. Past returns do not predict future ones. What do therapeutics and medical devices ETFs hold? Funds that hold drug developers and medical device makers, usually in one field such as oncology, neuroscience or vaccines. Between them the 5 therapeutics and medical devices ETFs ETFIQ can read name 45 companies in their ten largest holdings, by holdings dated Jun 30, 2026 to Oct 26, 2026, most widely ALKERMES PLC, which is among the ten largest of 2 of them. Do therapeutics and medical devices ETFs hold the same companies? It depends which two. Across the 10 pairs of the 5 therapeutics and medical devices ETFs with a full published book, by holdings dated Jun 30, 2026 to Oct 26, 2026, IHI and MDEV hold 32% of their weight in the same companies, MDEV and PSIL hold 0%, and the middle pair holds 0%. Two funds sold on one theme are not the same fund. What the issuers say about this theme\n The issuers behind these therapeutics and medical devices funds publish their own work on this theme. These are their pages and words, not ETFIQ\u2019s. A fund company writing about a theme it sells is making a case.\n Issuer material on this theme. Links leave ETFIQ. Source: each issuer\u2019s own site. Issuer What they publish Kind \n iShares iShares Portfolio Insights Their research index \n Tema Tema ETFs insights Their research index \n First Trust First Trust Investment Insights Their research index \n \n Where to next\n The largest therapeutics and medical devices ETFs The cheapest therapeutics and medical devices ETFs The therapeutics ETFs least like the S&P 500 The therapeutics ETFs that returned most The most concentrated therapeutics ETFs Every thematic ETF Compare two funds The vocabulary Sources\n Fund holdings from SEC Form N-PORT and from the issuers\u2019 own daily files SEC EDGAR, full-text search of fund filings SEC Form N-PORT, what a fund filed it holds Rule 19a-1, what a distribution notice must say Links are sources, not endorsements.\n ETFIQ is an independent publisher and makes no recommendations. Standards and sources \n Cite this page. ETFIQ, Therapeutics and medical devices ETFs, data as of Oct 27, 2026. https://etfiq.com/themes/therapeutics Free to use with attribution for data ETFIQ computes; issuer data stays under its owner's terms. The underlying files are at Open data .\n Other forms Plain ETFIQ, Therapeutics and medical devices ETFs, data as of Oct 27, 2026. https://etfiq.com/themes/therapeutics APA ETFIQ. (Oct 27, 2026). Therapeutics and medical devices ETFs. Retrieved from https://etfiq.com/themes/therapeutics Markdown [Therapeutics and medical devices ETFs (ETFIQ, Oct 27, 2026)](https://etfiq.com/themes/therapeutics)","source":"ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.","publisher":{"@id":"https://etfiq.com/#org","name":"ETFIQ","url":"https://etfiq.com"},"license":"https://etfiq.com/license/","license_text":"Data ETFIQ computes is free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms.","citation":"ETFIQ, Therapeutics and medical devices ETFs, data as of Oct 27, 2026. https://etfiq.com/themes/therapeutics"}