# Healthcare innovation ETFs: 8 funds, largest first

> ETFIQ covers 8 healthcare innovation ETFs. The largest are OZEM ($54m), HELX ($35m) and HEAL ($31m); fees run 0.45% to 0.85%, as of Oct 12 to 27, 2026.

Data as of Oct 27, 2026. Rebuilt every trading night.

Data as of Oct 27, 2026 .

## Healthcare innovation ETFs

See every healthcare innovation ETF by what it holds, not by its name. Funds that hold the companies changing how healthcare is delivered, including the makers of the GLP-1 weight loss drugs and digital health businesses. 8 funds, largest first. Updated Oct 27, 2026. The typical fund carries 35% of its weight in S&P 500 stocks, the 21st most of the 53 themes with holdings on file.

8 US listed healthcare innovation ETFs

$54m The largest, OZEM

0.45% The cheapest, WDNA

+44.5% Best one year, WDNA

### The short answers

Least like the S&P 500 HELX , Franklin Genomic Advancements ETF, 14.9% of its weight in S&P 500 companies. Closest pair OZEM and THNR , 68% of their weight in the same companies.

### What these funds actually own

Between them the 8 funds' ten largest holdings name 61 companies, of which 16 appear in more than one. Eli Lilly & Co is among the ten largest of 4 of them, at an average of 8.3% of the fund.

| Company | Among the ten largest of | Average weight where it is | Largest, and in which fund |
| --- | --- | --- | --- |
| Eli Lilly & Co LLY | 4 of 8 | 8.3% | 14.7% in OZEM |
| NATERA INC NTRA | 3 of 8 | 6.3% | 9.2% in EKG |
| Novo Nordisk A/S NVO | 2 of 8 | 10.4% | 11.9% in OZEM |
| Pfizer Inc PFE | 2 of 8 | 7.1% | 8.4% in OZEM |
| GUARDANT HEALTH INC GH | 2 of 8 | 6.5% | 9.1% in HELX |
| IQVIA HOLDINGS INC IQV | 2 of 8 | 5.7% | 7.7% in EKG |
| GILEAD SCIENCES GILD | 2 of 8 | 5.7% | 5.7% in THNR |
| Amgen Inc AMGN | 2 of 8 | 5.5% | 6.2% in THNR |
| ABBVIE ABBV | 2 of 8 | 5.4% | 5.8% in THNR |
| Chugai Pharmaceutical Co Ltd 4519 JP | 2 of 8 | 5.3% | 5.4% in THNR |
| AstraZeneca PLC AZN | 2 of 8 | 4.9% | 5.7% in THNR |
| Roche Holding AG ROP SW | 2 of 8 | 4.9% | 6.0% in THNR |
| MODERNA MRNA | 2 of 8 | 4.5% | 4.9% in BMED |
| TWIST BIOSCIENCE CORP TWST | 2 of 8 | 4.4% | 6.0% in WDNA |
| VERTEX PHARMACEUTICALS INC VRTX | 2 of 8 | 3.0% | 3.2% in BMED |

The 15 most widely held of 61. Each row counts the ten largest holdings of each fund, so a fund missing from a row may still hold that company lower down. Weights are of the funds that name it, not of the theme.

### The 8 largest healthcare innovation ETFs

ETFIQ covers 8 healthcare innovation ETFs. The largest are OZEM ( $54m ), HELX ( $35m ) and HEAL ( $31m ); fees run 0.45% to 0.85% , as of Oct 12 to 27, 2026 .

- OZEM Roundhill GLP-1 & Weight Loss ETF $54m 0.59%

- HELX Franklin Genomic Advancements ETF $35m 0.50%

- HEAL Global X HealthTech ETF $31m 0.50%

- BMED iShares Health Innovation Active ETF $14m 0.55%

- EKG First Trust Nasdaq Lux Digital Health Solutions ETF $9.6m 0.65%

- THNR Amplify Weight Loss Drug & Treatment ETF $5.7m 0.59%

- WDNA WisdomTree BioRevolution Fund $2.7m 0.45%

- LGHT Langar Global HealthTech ETF $2.5m 0.85%

| Ticker | Fund | Issuer | Net assets | In the S&P 500 | Active share | Total return 1Y | vs its benchmark 1Y | Fee |
| --- | --- | --- | --- | --- | --- | --- | --- | --- |
| OZEM | Roundhill GLP-1 & Weight Loss ETF | Roundhill | $54m | 30.1% | 97.8% | +6.8% | not measured | 0.59% |
| HELX | Franklin Genomic Advancements ETF | Franklin | $35m | 14.9% | 97.2% | +28.9% | not measured | 0.50% |
| HEAL | Global X HealthTech ETF | Global X | $31m | 28.8% | 99.5% | −6.4% | not measured | 0.50% |
| BMED | iShares Health Innovation Active ETF | iShares | $14m | 57.7% | 95.6% | +24.8% | not measured | 0.55% |
| EKG | First Trust Nasdaq Lux Digital Health Solutions ETF | First Trust | $9.6m | 40.5% | 99.6% | +31.1% | not measured | 0.65% |
| THNR | Amplify Weight Loss Drug & Treatment ETF | Amplify | $5.7m | 45.1% | 96.5% | +8.1% | not measured | 0.59% |
| WDNA | WisdomTree BioRevolution Fund | WisdomTree | $2.7m | 25.9% | 95.3% | +44.5% | not measured | 0.45% |
| LGHT | Langar Global HealthTech ETF | Langar | $2.5m | 57.9% | 99.5% | +4.3% | not measured | 0.85% |

### How much of each pair is the same fund

The closest pair is OZEM and THNR , which hold 68% of their weight in the same companies. The furthest apart is LGHT and THNR at 0%. The middle pair of the 28 is 8%.

| | OZEM | HELX | HEAL | BMED | EKG | THNR | WDNA | LGHT |
| --- | --- | --- | --- | --- | --- | --- | --- | --- |
| OZEM | · | 6% | 0% | 7% | 0% | 68% | 13% | 0% |
| HELX | 6% | · | 3% | 13% | 22% | 7% | 34% | 2% |
| HEAL | 0% | 3% | · | 7% | 42% | 0% | 2% | 29% |
| BMED | 7% | 13% | 7% | · | 10% | 18% | 23% | 9% |
| EKG | 0% | 22% | 42% | 10% | · | 0% | 10% | 25% |
| THNR | 68% | 7% | 0% | 18% | 0% | · | 16% | 0% |
| WDNA | 13% | 34% | 2% | 23% | 10% | 16% | · | 5% |
| LGHT | 0% | 2% | 29% | 9% | 25% | 0% | 5% | · |

Weight overlap adds the smaller of the two weights for every company both funds hold. Funds with a cut-short book are left out, not compared short.

### What each fund holds alone

| Fund | Largest holding it alone has | Weight | All of its own names |
| --- | --- | --- | --- |
| OZEM | Ascletis Pharma Inc 1672 HK | 3.0% | 11.9% |
| HELX | LIGAND PHARMACEUTICALS INC LGND | 4.6% | 18.9% |
| HEAL | GE HEALTHCARE TECHNOLOGIES INC. | 4.2% | 26.7% |
| BMED | METTLER TOLEDO MTD | 3.6% | 23.5% |
| EKG | Globus Medical, Inc. (Class A) GMED | 3.4% | 8.9% |
| THNR | Invesco Government & Agency Portfolio 12/31/2031 AGPXX | 0.3% | 0.3% |
| WDNA | IMMUNOME INC IMNM | 2.3% | 30.6% |
| LGHT | Intuitive Surgical I | 9.9% | 29.6% |

### Questions people ask

How many healthcare innovation ETFs are there? ETFIQ covers 8 US listed healthcare innovation ETFs as of Oct 27, 2026. That is every one it can measure from the fund’s own published holdings. What is the largest healthcare innovation ETF? OZEM , Roundhill GLP-1 & Weight Loss ETF, at $54m in net assets as of Oct 27, 2026, the largest of the 8 healthcare innovation ETFs with a published size. What is the cheapest healthcare innovation ETF? WDNA , WisdomTree BioRevolution Fund, at 0.45% a year by its prospectus filed Oct 28, 2025, the lowest fee of the 8 healthcare innovation ETFs that publish one. Which healthcare innovation ETF has performed best over the past year? WDNA , WisdomTree BioRevolution Fund, at +44.5% total return over the year to Oct 27, 2026, the highest of the 8 healthcare innovation ETFs with a full year of trading behind them. Past returns do not predict future ones. What do healthcare innovation ETFs hold? Funds that hold the companies changing how healthcare is delivered, including the makers of the GLP-1 weight loss drugs and digital health businesses. Between them the 8 healthcare innovation ETFs ETFIQ can read name 61 companies in their ten largest holdings, by holdings dated May 31, 2026 to Oct 27, 2026, most widely Eli Lilly & Co, which is among the ten largest of 4 of them. Do healthcare innovation ETFs hold the same companies? It depends which two. Across the 28 pairs of the 8 healthcare innovation ETFs with a full published book, by holdings dated May 31, 2026 to Oct 27, 2026, OZEM and THNR hold 68% of their weight in the same companies, LGHT and THNR hold 0%, and the middle pair holds 8%. Two funds sold on one theme are not the same fund.

### What the issuers say about this theme

The issuers behind these healthcare innovation funds publish their own work on this theme. These are their pages and words, not ETFIQ’s. A fund company writing about a theme it sells is making a case.

| Issuer | What they publish | Kind |
| --- | --- | --- |
| Roundhill | Roundhill research blog | Their research index |
| Global X | Global X Insights, including The Next Big Theme | Their research index |
| iShares | iShares Portfolio Insights | Their research index |
| First Trust | First Trust Investment Insights | Their research index |
| Amplify | Amplify Insights | Their research index |
| WisdomTree | WisdomTree blog | Their research index |

### Where to next

### Sources

Links are sources, not endorsements.

ETFIQ is an independent publisher and makes no recommendations. Standards and sources

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Source: ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.
Cite: ETFIQ, Healthcare innovation ETFs, data as of Oct 27, 2026. https://etfiq.com/themes/health-innovation
Licence: https://etfiq.com/license/ Data ETFIQ computes is free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms.
HTML: https://etfiq.com/themes/health-innovation