{"url":"https://etfiq.com/themes/health-innovation","section":"themes","title":"Healthcare innovation ETFs: 8 funds, largest first | ETFIQ","description":"ETFIQ covers 8 healthcare innovation ETFs. The largest are OZEM ($54m), HELX ($35m) and HEAL ($31m); fees run 0.45% to 0.85%, as of Oct 12 to 27, 2026.","as_of":"Oct 27, 2026","structured_data":[{"@type":"FAQPage","mainEntity":[{"@type":"Question","name":"How many healthcare innovation ETFs are there?","acceptedAnswer":{"@type":"Answer","text":"ETFIQ covers 8 US listed healthcare innovation ETFs as of Oct 27, 2026. That is every one it can measure from the fund\u2019s own published holdings."}},{"@type":"Question","name":"What is the largest healthcare innovation ETF?","acceptedAnswer":{"@type":"Answer","text":"OZEM, Roundhill GLP-1 & Weight Loss ETF, at $54m in net assets as of Oct 27, 2026, the largest of the 8 healthcare innovation ETFs with a published size."}},{"@type":"Question","name":"What is the cheapest healthcare innovation ETF?","acceptedAnswer":{"@type":"Answer","text":"WDNA, WisdomTree BioRevolution Fund, at 0.45% a year by its prospectus filed Oct 28, 2025, the lowest fee of the 8 healthcare innovation ETFs that publish one."}},{"@type":"Question","name":"Which healthcare innovation ETF has performed best over the past year?","acceptedAnswer":{"@type":"Answer","text":"WDNA, WisdomTree BioRevolution Fund, at +44.5% total return over the year to Oct 27, 2026, the highest of the 8 healthcare innovation ETFs with a full year of trading behind them. Past returns do not predict future ones."}},{"@type":"Question","name":"What do healthcare innovation ETFs hold?","acceptedAnswer":{"@type":"Answer","text":"Funds that hold the companies changing how healthcare is delivered, including the makers of the GLP-1 weight loss drugs and digital health businesses. Between them the 8 healthcare innovation ETFs ETFIQ can read name 61 companies in their ten largest holdings, by holdings dated May 31, 2026 to Oct 27, 2026, most widely Eli Lilly & Co, which is among the ten largest of 4 of them."}},{"@type":"Question","name":"Do healthcare innovation ETFs hold the same companies?","acceptedAnswer":{"@type":"Answer","text":"It depends which two. Across the 28 pairs of the 8 healthcare innovation ETFs with a full published book, by holdings dated May 31, 2026 to Oct 27, 2026, OZEM and THNR hold 68% of their weight in the same companies, LGHT and THNR hold 0%, and the middle pair holds 8%. Two funds sold on one theme are not the same fund."}}]},{"@type":"ItemList","name":"Healthcare innovation ETFs: 8 funds, largest first","numberOfItems":8,"itemListElement":[{"@type":"ListItem","position":1,"name":"OZEM","url":"https://etfiq.com/funds/ozem"},{"@type":"ListItem","position":2,"name":"HELX","url":"https://etfiq.com/funds/helx"},{"@type":"ListItem","position":3,"name":"HEAL","url":"https://etfiq.com/funds/heal"},{"@type":"ListItem","position":4,"name":"BMED","url":"https://etfiq.com/funds/bmed"},{"@type":"ListItem","position":5,"name":"EKG","url":"https://etfiq.com/funds/ekg"},{"@type":"ListItem","position":6,"name":"THNR","url":"https://etfiq.com/funds/thnr"},{"@type":"ListItem","position":7,"name":"WDNA","url":"https://etfiq.com/funds/wdna"},{"@type":"ListItem","position":8,"name":"LGHT","url":"https://etfiq.com/funds/lght"}]},{"@type":"ItemList","name":"The 8 largest healthcare innovation ETFs","itemListOrder":"https://schema.org/ItemListOrderDescending","numberOfItems":8,"itemListElement":[{"@type":"ListItem","position":1,"name":"OZEM","url":"https://etfiq.com/funds/ozem"},{"@type":"ListItem","position":2,"name":"HELX","url":"https://etfiq.com/funds/helx"},{"@type":"ListItem","position":3,"name":"HEAL","url":"https://etfiq.com/funds/heal"},{"@type":"ListItem","position":4,"name":"BMED","url":"https://etfiq.com/funds/bmed"},{"@type":"ListItem","position":5,"name":"EKG","url":"https://etfiq.com/funds/ekg"},{"@type":"ListItem","position":6,"name":"THNR","url":"https://etfiq.com/funds/thnr"},{"@type":"ListItem","position":7,"name":"WDNA","url":"https://etfiq.com/funds/wdna"},{"@type":"ListItem","position":8,"name":"LGHT","url":"https://etfiq.com/funds/lght"}]},{"@type":"Dataset","name":"Healthcare innovation ETFs","description":"ETFIQ covers 8 healthcare innovation ETFs. The largest are OZEM ($54m), HELX ($35m) and HEAL ($31m); fees run 0.45% to 0.85%, as of Oct 12 to 27, 2026.","url":"https://etfiq.com/themes/health-innovation","dateModified":"2026-10-27","inLanguage":"en","creator":{"@id":"https://etfiq.com/#org"},"publisher":{"@id":"https://etfiq.com/#org"},"license":"https://etfiq.com/license/","isAccessibleForFree":true,"creativeWorkStatus":"Published","distribution":[{"@type":"DataDownload","encodingFormat":"application/json","contentUrl":"https://etfiq.com/data/thematic.json"}],"variableMeasured":["Weight overlap with the S&P 500","Active share","Holdings","Top ten share of the fund","Total return","Fee for the differing part","Expense ratio"],"keywords":["exchange-traded funds","ETF","Thematic ETFs","fund data","SEC filings"]},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"ETFIQ","item":"https://etfiq.com/"},{"@type":"ListItem","position":2,"name":"Thematic ETFs","item":"https://etfiq.com/themes/"},{"@type":"ListItem","position":3,"name":"Healthcare innovation","item":"https://etfiq.com/themes/health-innovation"}]},{"@type":"WebPage","name":"Healthcare innovation ETFs: 8 funds, largest first","description":"ETFIQ covers 8 healthcare innovation ETFs. The largest are OZEM ($54m), HELX ($35m) and HEAL ($31m); fees run 0.45% to 0.85%, as of Oct 12 to 27, 2026.","url":"https://etfiq.com/themes/health-innovation","dateModified":"2026-10-27","isPartOf":{"@type":"WebSite","name":"ETFIQ","url":"https://etfiq.com"},"speakable":{"@type":"SpeakableSpecification","cssSelector":[".lede",".faq"]},"publisher":{"@id":"https://etfiq.com/#org"}}],"characters":9024,"truncated":false,"content":"ETFIQ / Thematic ETFs / Healthcare innovation \n \n Data as of Oct 27, 2026 .\n Healthcare innovation ETFs\n See every healthcare innovation ETF by what it holds, not by its name. Funds that hold the companies changing how healthcare is delivered, including the makers of the GLP-1 weight loss drugs and digital health businesses. 8 funds, largest first. Updated Oct 27, 2026. The typical fund carries 35% of its weight in S&P 500 stocks, the 21st most of the 53 themes with holdings on file.\n 8 US listed healthcare innovation ETFs \n $54m The largest, OZEM \n 0.45% The cheapest, WDNA \n +44.5% Best one year, WDNA \n\n The short answers\n Least like the S&P 500 HELX , Franklin Genomic Advancements ETF, 14.9% of its weight in S&P 500 companies. Closest pair OZEM and THNR , 68% of their weight in the same companies. What these funds actually own\n Between them the 8 funds' ten largest holdings name 61 companies, of which 16 appear in more than one. Eli Lilly & Co is among the ten largest of 4 of them, at an average of 8.3% of the fund.\n Healthcare innovation and GLP-1 ETFs, the companies their ten largest holdings name. Source: each fund's latest SEC filing or its issuer\u2019s own daily holdings file, read by ETFIQ. Company Among the ten largest of Average weight where it is Largest, and in which fund \n Eli Lilly & Co LLY 4 of 8 8.3% 14.7% in OZEM \n NATERA INC NTRA 3 of 8 6.3% 9.2% in EKG \n Novo Nordisk A/S NVO 2 of 8 10.4% 11.9% in OZEM \n Pfizer Inc PFE 2 of 8 7.1% 8.4% in OZEM \n GUARDANT HEALTH INC GH 2 of 8 6.5% 9.1% in HELX \n IQVIA HOLDINGS INC IQV 2 of 8 5.7% 7.7% in EKG \n GILEAD SCIENCES GILD 2 of 8 5.7% 5.7% in THNR \n Amgen Inc AMGN 2 of 8 5.5% 6.2% in THNR \n ABBVIE ABBV 2 of 8 5.4% 5.8% in THNR \n Chugai Pharmaceutical Co Ltd 4519 JP 2 of 8 5.3% 5.4% in THNR \n AstraZeneca PLC AZN 2 of 8 4.9% 5.7% in THNR \n Roche Holding AG ROP SW 2 of 8 4.9% 6.0% in THNR \n MODERNA MRNA 2 of 8 4.5% 4.9% in BMED \n TWIST BIOSCIENCE CORP TWST 2 of 8 4.4% 6.0% in WDNA \n VERTEX PHARMACEUTICALS INC VRTX 2 of 8 3.0% 3.2% in BMED \n \n The 15 most widely held of 61. Each row counts the ten largest holdings of each fund, so a fund missing from a row may still hold that company lower down. Weights are of the funds that name it, not of the theme.\n The 8 largest healthcare innovation ETFs\n ETFIQ covers 8 healthcare innovation ETFs. The largest are OZEM ( $54m ), HELX ( $35m ) and HEAL ( $31m ); fees run 0.45% to 0.85% , as of Oct 12 to 27, 2026 .\n OZEM Roundhill GLP-1 & Weight Loss ETF $54m 0.59% \n HELX Franklin Genomic Advancements ETF $35m 0.50% \n HEAL Global X HealthTech ETF $31m 0.50% \n BMED iShares Health Innovation Active ETF $14m 0.55% \n EKG First Trust Nasdaq Lux Digital Health Solutions ETF $9.6m 0.65% \n THNR Amplify Weight Loss Drug & Treatment ETF $5.7m 0.59% \n WDNA WisdomTree BioRevolution Fund $2.7m 0.45% \n LGHT Langar Global HealthTech ETF $2.5m 0.85% \n \n Healthcare innovation ETFs, as of Oct 27, 2026. Source: ETFIQ. Ticker Fund Issuer Net assets In the S&P 500 Active share Total return 1Y vs its benchmark 1Y Fee \n OZEM Roundhill GLP-1 & Weight Loss ETF Roundhill $54m 30.1% 97.8% +6.8% not measured 0.59% \n HELX Franklin Genomic Advancements ETF Franklin $35m 14.9% 97.2% +28.9% not measured 0.50% \n HEAL Global X HealthTech ETF Global X $31m 28.8% 99.5% \u22126.4% not measured 0.50% \n BMED iShares Health Innovation Active ETF iShares $14m 57.7% 95.6% +24.8% not measured 0.55% \n EKG First Trust Nasdaq Lux Digital Health Solutions ETF First Trust $9.6m 40.5% 99.6% +31.1% not measured 0.65% \n THNR Amplify Weight Loss Drug & Treatment ETF Amplify $5.7m 45.1% 96.5% +8.1% not measured 0.59% \n WDNA WisdomTree BioRevolution Fund WisdomTree $2.7m 25.9% 95.3% +44.5% not measured 0.45% \n LGHT Langar Global HealthTech ETF Langar $2.5m 57.9% 99.5% +4.3% not measured 0.85% \n \n How much of each pair is the same fund\n The closest pair is OZEM and THNR , which hold 68% of their weight in the same companies. The furthest apart is LGHT and THNR at 0%. The middle pair of the 28 is 8%.\n Healthcare innovation ETFs, the share of each pair\u2019s weight held in the same companies. Read across or down; the number is the same either way. Cells are shaded against the closest pair here, 68%. Source: each fund\u2019s own filed or daily holdings, read by ETFIQ. OZEM HELX HEAL BMED EKG THNR WDNA LGHT \n OZEM \u00b7 6% 0% 7% 0% 68% 13% 0% \n HELX 6% \u00b7 3% 13% 22% 7% 34% 2% \n HEAL 0% 3% \u00b7 7% 42% 0% 2% 29% \n BMED 7% 13% 7% \u00b7 10% 18% 23% 9% \n EKG 0% 22% 42% 10% \u00b7 0% 10% 25% \n THNR 68% 7% 0% 18% 0% \u00b7 16% 0% \n WDNA 13% 34% 2% 23% 10% 16% \u00b7 5% \n LGHT 0% 2% 29% 9% 25% 0% 5% \u00b7 \n \n Weight overlap adds the smaller of the two weights for every company both funds hold. Funds with a cut-short book are left out, not compared short.\n What each fund holds alone\n Healthcare innovation ETFs, the largest holding no other fund in the grid holds. Source: ETFIQ. Fund Largest holding it alone has Weight All of its own names \n OZEM Ascletis Pharma Inc 1672 HK 3.0% 11.9% \n HELX LIGAND PHARMACEUTICALS INC LGND 4.6% 18.9% \n HEAL GE HEALTHCARE TECHNOLOGIES INC. 4.2% 26.7% \n BMED METTLER TOLEDO MTD 3.6% 23.5% \n EKG Globus Medical, Inc. (Class A) GMED 3.4% 8.9% \n THNR Invesco Government & Agency Portfolio 12/31/2031 AGPXX 0.3% 0.3% \n WDNA IMMUNOME INC IMNM 2.3% 30.6% \n LGHT Intuitive Surgical I 9.9% 29.6% \n \n Questions people ask\n How many healthcare innovation ETFs are there? ETFIQ covers 8 US listed healthcare innovation ETFs as of Oct 27, 2026. That is every one it can measure from the fund\u2019s own published holdings. What is the largest healthcare innovation ETF? OZEM , Roundhill GLP-1 & Weight Loss ETF, at $54m in net assets as of Oct 27, 2026, the largest of the 8 healthcare innovation ETFs with a published size. What is the cheapest healthcare innovation ETF? WDNA , WisdomTree BioRevolution Fund, at 0.45% a year by its prospectus filed Oct 28, 2025, the lowest fee of the 8 healthcare innovation ETFs that publish one. Which healthcare innovation ETF has performed best over the past year? WDNA , WisdomTree BioRevolution Fund, at +44.5% total return over the year to Oct 27, 2026, the highest of the 8 healthcare innovation ETFs with a full year of trading behind them. Past returns do not predict future ones. What do healthcare innovation ETFs hold? Funds that hold the companies changing how healthcare is delivered, including the makers of the GLP-1 weight loss drugs and digital health businesses. Between them the 8 healthcare innovation ETFs ETFIQ can read name 61 companies in their ten largest holdings, by holdings dated May 31, 2026 to Oct 27, 2026, most widely Eli Lilly & Co, which is among the ten largest of 4 of them. Do healthcare innovation ETFs hold the same companies? It depends which two. Across the 28 pairs of the 8 healthcare innovation ETFs with a full published book, by holdings dated May 31, 2026 to Oct 27, 2026, OZEM and THNR hold 68% of their weight in the same companies, LGHT and THNR hold 0%, and the middle pair holds 8%. Two funds sold on one theme are not the same fund. What the issuers say about this theme\n The issuers behind these healthcare innovation funds publish their own work on this theme. These are their pages and words, not ETFIQ\u2019s. A fund company writing about a theme it sells is making a case.\n Issuer material on this theme. Links leave ETFIQ. Source: each issuer\u2019s own site. Issuer What they publish Kind \n Roundhill Roundhill research blog Their research index \n Global X Global X Insights, including The Next Big Theme Their research index \n iShares iShares Portfolio Insights Their research index \n First Trust First Trust Investment Insights Their research index \n Amplify Amplify Insights Their research index \n WisdomTree WisdomTree blog Their research index \n \n Where to next\n The largest healthcare innovation ETFs The cheapest healthcare innovation ETFs The healthcare innovation ETFs least like the index The healthcare innovation ETFs that returned most The most concentrated healthcare innovation ETFs Every thematic ETF Compare two funds The vocabulary Sources\n Fund holdings from SEC Form N-PORT and from the issuers\u2019 own daily files SEC EDGAR, full-text search of fund filings SEC Form N-PORT, what a fund filed it holds Rule 19a-1, what a distribution notice must say Links are sources, not endorsements.\n ETFIQ is an independent publisher and makes no recommendations. Standards and sources \n Cite this page. ETFIQ, Healthcare innovation ETFs, data as of Oct 27, 2026. https://etfiq.com/themes/health-innovation Free to use with attribution for data ETFIQ computes; issuer data stays under its owner's terms. The underlying files are at Open data .\n Other forms Plain ETFIQ, Healthcare innovation ETFs, data as of Oct 27, 2026. https://etfiq.com/themes/health-innovation APA ETFIQ. (Oct 27, 2026). Healthcare innovation ETFs. Retrieved from https://etfiq.com/themes/health-innovation Markdown [Healthcare innovation ETFs (ETFIQ, Oct 27, 2026)](https://etfiq.com/themes/health-innovation)","source":"ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.","publisher":{"@id":"https://etfiq.com/#org","name":"ETFIQ","url":"https://etfiq.com"},"license":"https://etfiq.com/license/","license_text":"Data ETFIQ computes is free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms.","citation":"ETFIQ, Healthcare innovation ETFs, data as of Oct 27, 2026. https://etfiq.com/themes/health-innovation"}