# Biotechnology ETFs: 10 funds, largest first

> ETFIQ covers 10 biotech ETFs. The largest are IBB ($11.2bn), XBI ($10.6bn) and FBT ($3.1bn); fees run 0.13% to 0.65%, as of Nov 3, 2026.

Data as of Nov 4, 2026. Rebuilt every trading night.

Data as of Nov 4, 2026 .

## Biotech ETFs: what each one holds

See every biotech ETF by what it holds, not by its name. Funds that hold drug developers, usually a broad basket of them rather than one field. 10 funds, largest first. Updated Nov 4, 2026. The typical fund carries 32% of its weight in S&P 500 stocks, the 24th most of the 54 themes with holdings on file.

10 US listed biotech ETFs

$11.2bn The largest, IBB

0.13% The cheapest, PBPH

+47.9% Best one year, XBI

### The short answers

Least like the S&P 500 BBC , Virtus Biotech Clinical Trials ETF, 0.0% of its weight in S&P 500 companies. Closest pair IBB and IBBQ , 85% of their weight in the same companies.

### What these funds actually own

Between them the 9 funds' ten largest holdings name 48 companies, of which 13 appear in more than one. AMGEN INC is among the ten largest of 7 of them, at an average of 6.9% of the fund.

| Company | Among the ten largest of | Average weight where it is | Largest, and in which fund |
| --- | --- | --- | --- |
| AMGEN INC AMGN | 7 of 9 | 6.9% | 16.7% in BBH |
| GILEAD SCIENCES GILD | 7 of 9 | 6.7% | 14.5% in BBH |
| REGENERON PHARMACEUTICALS REGN | 7 of 9 | 4.9% | 7.9% in BBH |
| MODERNA MRNA | 5 of 9 | 4.9% | 6.7% in BBH |
| BIOGEN BIIB | 5 of 9 | 3.1% | 5.4% in PBE |
| VERTEX PHARMACEUTICALS VRTX | 4 of 9 | 7.0% | 8.3% in BBH |
| NATERA NTRA | 4 of 9 | 3.8% | 5.6% in PBE |
| ILLUMINA INC ILMN | 4 of 9 | 3.3% | 5.1% in PBE |
| EXELIXIS INC EXEL | 3 of 9 | 3.0% | 3.9% in FBT |
| REVOLUTION MEDICINES RVMD | 3 of 9 | 3.0% | 3.7% in BBH |
| ARGENX SE ADR ARGX | 2 of 9 | 3.7% | 4.0% in BBH |
| Royalty Pharma PLC RPRX | 2 of 9 | 3.5% | 5.2% in PBE |
| HALOZYME THERAPEUTICS INC HALO | 2 of 9 | 2.7% | 3.7% in FBT |
| ELI LILLY & COMPANY LLY | 1 of 9 | 15.2% | 15.2% in PBPH |
| JOHNSON & JOHNSON JNJ | 1 of 9 | 9.7% | 9.7% in PBPH |

The 15 most widely held of 48. Each row counts the ten largest holdings of each fund, so a fund missing from a row may still hold that company lower down. Weights are of the funds that name it, not of the theme.

### The 10 largest biotech ETFs

ETFIQ covers 10 biotech ETFs. The largest are IBB ( $11.2bn ), XBI ( $10.6bn ) and FBT ( $3.1bn ); fees run 0.13% to 0.65% , as of Nov 3, 2026 .

- IBB iShares Biotechnology ETF $11.2bn 0.44%

- XBI State Street SPDR S&P Biotech ETF $10.6bn 0.35%

- FBT First Trust NYSE Arca Biotechnology Index Fund $3.1bn 0.55%

- PBPH Portfolio Building Block World Pharma and Biotech Index ETF $952m 0.13%

- BBH VanEck Biotech ETF $525m 0.35%

- PBE Invesco Biotechnology & Genome ETF $442m 0.59%

- IBBQ Invesco Nasdaq Biotechnology ETF $121m 0.19%

- BBP Virtus Biotech ETF $99m 0.34%

- BBC Virtus Biotech Clinical Trials ETF $46m 0.65%

- TDNA T. Rowe Price Biotech ETF $11m 0.55%

| Ticker | Fund | Issuer | Net assets | In the S&P 500 | Active share | Total return 1Y | vs its benchmark 1Y | Fee |
| --- | --- | --- | --- | --- | --- | --- | --- | --- |
| IBB | iShares Biotechnology ETF | iShares | $11.2bn | 42.0% | 99.0% | +42.0% | not measured | 0.44% |
| XBI | State Street SPDR S&P Biotech ETF | State Street | $10.6bn | 13.9% | 98.4% | +47.9% | not measured | 0.35% |
| FBT | First Trust NYSE Arca Biotechnology Index Fund | First Trust | $3.1bn | 24.8% | 99.1% | +47.0% | not measured | 0.55% |
| PBPH | Portfolio Building Block World Pharma and Biotech Index ETF | Portfolio Building Block | $952m | 59.2% | 95.0% | first traded 344 days ago | · | 0.13% |
| BBH | VanEck Biotech ETF | VanEck | $525m | 64.4% | 99.0% | +47.2% | not measured | 0.35% |
| PBE | Invesco Biotechnology & Genome ETF | Invesco | $442m | 32.3% | 99.0% | +44.2% | not measured | 0.59% |
| IBBQ | Invesco Nasdaq Biotechnology ETF | Invesco | $121m | 42.5% | 99.0% | +42.7% | not measured | 0.19% |
| BBP | Virtus Biotech ETF | Virtus | $99m | 10.5% | 99.0% | +44.4% | not measured | 0.34% |
| BBC | Virtus Biotech Clinical Trials ETF | Virtus | $46m | 0.0% | 100.0% | +45.9% | not measured | 0.65% |
| TDNA | T. Rowe Price Biotech ETF | T. Rowe Price | $11m | not yet filed | not yet filed | first traded 48 days ago | · | 0.55% |

### How much of each pair is the same fund

The closest pair is IBB and IBBQ , which hold 85% of their weight in the same companies. The furthest apart is BBC and FBT at 0%. The middle pair of the 36 is 28%. The grid is the 9 largest of 10 funds.

| | IBB | XBI | FBT | PBPH | BBH | PBE | IBBQ | BBP | BBC |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| IBB | · | 43% | 44% | 22% | 65% | 43% | 85% | 32% | 12% |
| XBI | 43% | · | 26% | 15% | 22% | 31% | 43% | 46% | 31% |
| FBT | 44% | 26% | · | 18% | 41% | 49% | 33% | 27% | 0% |
| PBPH | 22% | 15% | 18% | · | 21% | 18% | 23% | 11% | 1% |
| BBH | 65% | 22% | 41% | 21% | · | 43% | 58% | 20% | 1% |
| PBE | 43% | 31% | 49% | 18% | 43% | · | 40% | 30% | 1% |
| IBBQ | 85% | 43% | 33% | 23% | 58% | 40% | · | 33% | 13% |
| BBP | 32% | 46% | 27% | 11% | 20% | 30% | 33% | · | 0% |
| BBC | 12% | 31% | 0% | 1% | 1% | 1% | 13% | 0% | · |

Weight overlap adds the smaller of the two weights for every company both funds hold. Funds with a cut-short book are left out, not compared short.

### What each fund holds alone

| Fund | Largest holding it alone has | Weight | All of its own names |
| --- | --- | --- | --- |
| IBB | CYTEK BIOSCIENCES CTKB | 0.1% | 0.3% |
| XBI | HYPERLIQUID STRATEGIES PURR | 0.6% | 1.4% |
| FBT | NeoGenomics, Inc. NEO | 3.3% | 5.5% |
| PBPH | JOHNSON & JOHNSON JNJ | 9.7% | 48.1% |
| BBH | Iqvia Holdings Inc IQV | 4.2% | 5.6% |
| IBBQ | Amneal Pharmaceuticals Inc AMRX | 0.5% | 1.8% |
| BBP | CRINETICS PHARMACEUTICALS INC CRNX | 3.3% | 6.4% |
| BBC | ATAIBECKLEY INC ATAI | 1.2% | 12.5% |

### Questions people ask

How many biotech ETFs are there? ETFIQ covers 10 US listed biotech ETFs as of Nov 4, 2026. That is every one it can measure from the fund’s own published holdings. What is the largest biotech ETF? IBB , iShares Biotechnology ETF, at $11.2bn in net assets as of Nov 3, 2026, the largest of the 10 biotech ETFs with a published size. What is the cheapest biotech ETF? PBPH , Portfolio Building Block World Pharma and Biotech Index ETF, at 0.13% a year by its prospectus filed Oct 27, 2025, the lowest fee of the 10 biotech ETFs that publish one. Which biotech ETF has performed best over the past year? XBI , State Street SPDR S&P Biotech ETF, at +47.9% total return over the year to Nov 4, 2026, the highest of the 8 biotech ETFs with a full year of trading behind them. Past returns do not predict future ones. What do biotech ETFs hold? Funds that hold drug developers, usually a broad basket of them rather than one field. Between them the 9 biotech ETFs ETFIQ can read name 48 companies in their ten largest holdings, by holdings dated Jul 31, 2026 to Nov 3, 2026, most widely AMGEN INC, which is among the ten largest of 7 of them. Do biotech ETFs hold the same companies? It depends which two. Across the 36 pairs of the 9 biotech ETFs with a full published book, by holdings dated Jul 31, 2026 to Nov 3, 2026, IBB and IBBQ hold 85% of their weight in the same companies, BBC and FBT hold 0%, and the middle pair holds 28%. Two funds sold on one theme are not the same fund.

### What the issuers say about this theme

The issuers behind these biotech funds publish their own work on this theme. These are their pages and words, not ETFIQ’s. A fund company writing about a theme it sells is making a case.

| Issuer | What they publish | Kind |
| --- | --- | --- |
| iShares | iShares Portfolio Insights | Their research index |
| First Trust | First Trust Investment Insights | Their research index |
| VanEck | VanEck Insights | Their research index |
| Invesco | Invesco insights | Their research index |

### Where to next

### Sources

Links are sources, not endorsements.

ETFIQ is an independent publisher and makes no recommendations. Standards and sources

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Source: ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.
Cite: ETFIQ, Biotech ETFs: what each one holds, data as of Nov 4, 2026. https://etfiq.com/themes/biotech
Licence: https://etfiq.com/license/ Data ETFIQ computes is free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms.
HTML: https://etfiq.com/themes/biotech