{"url":"https://etfiq.com/themes/biotech","section":"themes","title":"Biotechnology ETFs: 10 funds, largest first | ETFIQ","description":"ETFIQ covers 10 biotech ETFs. The largest are IBB ($11.2bn), XBI ($10.6bn) and FBT ($3.1bn); fees run 0.13% to 0.65%, as of Nov 3, 2026.","as_of":"Nov 4, 2026","structured_data":[{"@type":"FAQPage","mainEntity":[{"@type":"Question","name":"How many biotech ETFs are there?","acceptedAnswer":{"@type":"Answer","text":"ETFIQ covers 10 US listed biotech ETFs as of Nov 4, 2026. That is every one it can measure from the fund\u2019s own published holdings."}},{"@type":"Question","name":"What is the largest biotech ETF?","acceptedAnswer":{"@type":"Answer","text":"IBB, iShares Biotechnology ETF, at $11.2bn in net assets as of Nov 3, 2026, the largest of the 10 biotech ETFs with a published size."}},{"@type":"Question","name":"What is the cheapest biotech ETF?","acceptedAnswer":{"@type":"Answer","text":"PBPH, Portfolio Building Block World Pharma and Biotech Index ETF, at 0.13% a year by its prospectus filed Oct 27, 2025, the lowest fee of the 10 biotech ETFs that publish one."}},{"@type":"Question","name":"Which biotech ETF has performed best over the past year?","acceptedAnswer":{"@type":"Answer","text":"XBI, State Street SPDR S&P Biotech ETF, at +47.9% total return over the year to Nov 4, 2026, the highest of the 8 biotech ETFs with a full year of trading behind them. Past returns do not predict future ones."}},{"@type":"Question","name":"What do biotech ETFs hold?","acceptedAnswer":{"@type":"Answer","text":"Funds that hold drug developers, usually a broad basket of them rather than one field. Between them the 9 biotech ETFs ETFIQ can read name 48 companies in their ten largest holdings, by holdings dated Jul 31, 2026 to Nov 3, 2026, most widely AMGEN INC, which is among the ten largest of 7 of them."}},{"@type":"Question","name":"Do biotech ETFs hold the same companies?","acceptedAnswer":{"@type":"Answer","text":"It depends which two. Across the 36 pairs of the 9 biotech ETFs with a full published book, by holdings dated Jul 31, 2026 to Nov 3, 2026, IBB and IBBQ hold 85% of their weight in the same companies, BBC and FBT hold 0%, and the middle pair holds 28%. Two funds sold on one theme are not the same fund."}}]},{"@type":"ItemList","name":"Biotechnology ETFs: 10 funds, largest first","numberOfItems":10,"itemListElement":[{"@type":"ListItem","position":1,"name":"IBB","url":"https://etfiq.com/funds/ibb"},{"@type":"ListItem","position":2,"name":"XBI","url":"https://etfiq.com/funds/xbi"},{"@type":"ListItem","position":3,"name":"FBT","url":"https://etfiq.com/funds/fbt"},{"@type":"ListItem","position":4,"name":"PBPH","url":"https://etfiq.com/funds/pbph"},{"@type":"ListItem","position":5,"name":"BBH","url":"https://etfiq.com/funds/bbh"},{"@type":"ListItem","position":6,"name":"PBE","url":"https://etfiq.com/funds/pbe"},{"@type":"ListItem","position":7,"name":"IBBQ","url":"https://etfiq.com/funds/ibbq"},{"@type":"ListItem","position":8,"name":"BBP","url":"https://etfiq.com/funds/bbp"},{"@type":"ListItem","position":9,"name":"BBC","url":"https://etfiq.com/funds/bbc"},{"@type":"ListItem","position":10,"name":"TDNA","url":"https://etfiq.com/funds/tdna"}]},{"@type":"ItemList","name":"The 10 largest biotech ETFs","itemListOrder":"https://schema.org/ItemListOrderDescending","numberOfItems":10,"itemListElement":[{"@type":"ListItem","position":1,"name":"IBB","url":"https://etfiq.com/funds/ibb"},{"@type":"ListItem","position":2,"name":"XBI","url":"https://etfiq.com/funds/xbi"},{"@type":"ListItem","position":3,"name":"FBT","url":"https://etfiq.com/funds/fbt"},{"@type":"ListItem","position":4,"name":"PBPH","url":"https://etfiq.com/funds/pbph"},{"@type":"ListItem","position":5,"name":"BBH","url":"https://etfiq.com/funds/bbh"},{"@type":"ListItem","position":6,"name":"PBE","url":"https://etfiq.com/funds/pbe"},{"@type":"ListItem","position":7,"name":"IBBQ","url":"https://etfiq.com/funds/ibbq"},{"@type":"ListItem","position":8,"name":"BBP","url":"https://etfiq.com/funds/bbp"},{"@type":"ListItem","position":9,"name":"BBC","url":"https://etfiq.com/funds/bbc"},{"@type":"ListItem","position":10,"name":"TDNA","url":"https://etfiq.com/funds/tdna"}]},{"@type":"Dataset","name":"Biotech ETFs: what each one holds","description":"ETFIQ covers 10 biotech ETFs. The largest are IBB ($11.2bn), XBI ($10.6bn) and FBT ($3.1bn); fees run 0.13% to 0.65%, as of Nov 3, 2026.","url":"https://etfiq.com/themes/biotech","dateModified":"2026-11-04","inLanguage":"en","creator":{"@id":"https://etfiq.com/#org"},"publisher":{"@id":"https://etfiq.com/#org"},"license":"https://etfiq.com/license/","isAccessibleForFree":true,"creativeWorkStatus":"Published","distribution":[{"@type":"DataDownload","encodingFormat":"application/json","contentUrl":"https://etfiq.com/data/thematic.json"}],"variableMeasured":["Weight overlap with the S&P 500","Active share","Holdings","Top ten share of the fund","Total return","Fee for the differing part","Expense ratio"],"keywords":["exchange-traded funds","ETF","Thematic ETFs","fund data","SEC filings"]},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"ETFIQ","item":"https://etfiq.com/"},{"@type":"ListItem","position":2,"name":"Thematic ETFs","item":"https://etfiq.com/themes/"},{"@type":"ListItem","position":3,"name":"Biotech","item":"https://etfiq.com/themes/biotech"}]},{"@type":"WebPage","name":"Biotechnology ETFs: 10 funds, largest first","description":"ETFIQ covers 10 biotech ETFs. The largest are IBB ($11.2bn), XBI ($10.6bn) and FBT ($3.1bn); fees run 0.13% to 0.65%, as of Nov 3, 2026.","url":"https://etfiq.com/themes/biotech","dateModified":"2026-11-04","isPartOf":{"@type":"WebSite","name":"ETFIQ","url":"https://etfiq.com"},"speakable":{"@type":"SpeakableSpecification","cssSelector":[".lede",".faq"]},"publisher":{"@id":"https://etfiq.com/#org"}}],"characters":8833,"truncated":false,"content":"ETFIQ / Thematic ETFs / Biotech \n \n Data as of Nov 4, 2026 .\n Biotech ETFs: what each one holds\n See every biotech ETF by what it holds, not by its name. Funds that hold drug developers, usually a broad basket of them rather than one field. 10 funds, largest first. Updated Nov 4, 2026. The typical fund carries 32% of its weight in S&P 500 stocks, the 24th most of the 54 themes with holdings on file.\n 10 US listed biotech ETFs \n $11.2bn The largest, IBB \n 0.13% The cheapest, PBPH \n +47.9% Best one year, XBI \n\n The short answers\n Least like the S&P 500 BBC , Virtus Biotech Clinical Trials ETF, 0.0% of its weight in S&P 500 companies. Closest pair IBB and IBBQ , 85% of their weight in the same companies. What these funds actually own\n Between them the 9 funds' ten largest holdings name 48 companies, of which 13 appear in more than one. AMGEN INC is among the ten largest of 7 of them, at an average of 6.9% of the fund.\n Biotech ETFs, the companies their ten largest holdings name. Source: each fund's latest SEC filing or its issuer\u2019s own daily holdings file, read by ETFIQ. Company Among the ten largest of Average weight where it is Largest, and in which fund \n AMGEN INC AMGN 7 of 9 6.9% 16.7% in BBH \n GILEAD SCIENCES GILD 7 of 9 6.7% 14.5% in BBH \n REGENERON PHARMACEUTICALS REGN 7 of 9 4.9% 7.9% in BBH \n MODERNA MRNA 5 of 9 4.9% 6.7% in BBH \n BIOGEN BIIB 5 of 9 3.1% 5.4% in PBE \n VERTEX PHARMACEUTICALS VRTX 4 of 9 7.0% 8.3% in BBH \n NATERA NTRA 4 of 9 3.8% 5.6% in PBE \n ILLUMINA INC ILMN 4 of 9 3.3% 5.1% in PBE \n EXELIXIS INC EXEL 3 of 9 3.0% 3.9% in FBT \n REVOLUTION MEDICINES RVMD 3 of 9 3.0% 3.7% in BBH \n ARGENX SE ADR ARGX 2 of 9 3.7% 4.0% in BBH \n Royalty Pharma PLC RPRX 2 of 9 3.5% 5.2% in PBE \n HALOZYME THERAPEUTICS INC HALO 2 of 9 2.7% 3.7% in FBT \n ELI LILLY & COMPANY LLY 1 of 9 15.2% 15.2% in PBPH \n JOHNSON & JOHNSON JNJ 1 of 9 9.7% 9.7% in PBPH \n \n The 15 most widely held of 48. Each row counts the ten largest holdings of each fund, so a fund missing from a row may still hold that company lower down. Weights are of the funds that name it, not of the theme.\n The 10 largest biotech ETFs\n ETFIQ covers 10 biotech ETFs. The largest are IBB ( $11.2bn ), XBI ( $10.6bn ) and FBT ( $3.1bn ); fees run 0.13% to 0.65% , as of Nov 3, 2026 .\n IBB iShares Biotechnology ETF $11.2bn 0.44% \n XBI State Street SPDR S&P Biotech ETF $10.6bn 0.35% \n FBT First Trust NYSE Arca Biotechnology Index Fund $3.1bn 0.55% \n PBPH Portfolio Building Block World Pharma and Biotech Index ETF $952m 0.13% \n BBH VanEck Biotech ETF $525m 0.35% \n PBE Invesco Biotechnology & Genome ETF $442m 0.59% \n IBBQ Invesco Nasdaq Biotechnology ETF $121m 0.19% \n BBP Virtus Biotech ETF $99m 0.34% \n BBC Virtus Biotech Clinical Trials ETF $46m 0.65% \n TDNA T. Rowe Price Biotech ETF $11m 0.55% \n \n Biotech ETFs: what each one holds, as of Nov 4, 2026. Source: ETFIQ. Ticker Fund Issuer Net assets In the S&P 500 Active share Total return 1Y vs its benchmark 1Y Fee \n IBB iShares Biotechnology ETF iShares $11.2bn 42.0% 99.0% +42.0% not measured 0.44% \n XBI State Street SPDR S&P Biotech ETF State Street $10.6bn 13.9% 98.4% +47.9% not measured 0.35% \n FBT First Trust NYSE Arca Biotechnology Index Fund First Trust $3.1bn 24.8% 99.1% +47.0% not measured 0.55% \n PBPH Portfolio Building Block World Pharma and Biotech Index ETF Portfolio Building Block $952m 59.2% 95.0% first traded 344 days ago \u00b7 0.13% \n BBH VanEck Biotech ETF VanEck $525m 64.4% 99.0% +47.2% not measured 0.35% \n PBE Invesco Biotechnology & Genome ETF Invesco $442m 32.3% 99.0% +44.2% not measured 0.59% \n IBBQ Invesco Nasdaq Biotechnology ETF Invesco $121m 42.5% 99.0% +42.7% not measured 0.19% \n BBP Virtus Biotech ETF Virtus $99m 10.5% 99.0% +44.4% not measured 0.34% \n BBC Virtus Biotech Clinical Trials ETF Virtus $46m 0.0% 100.0% +45.9% not measured 0.65% \n TDNA T. Rowe Price Biotech ETF T. Rowe Price $11m not yet filed not yet filed first traded 48 days ago \u00b7 0.55% \n \n How much of each pair is the same fund\n The closest pair is IBB and IBBQ , which hold 85% of their weight in the same companies. The furthest apart is BBC and FBT at 0%. The middle pair of the 36 is 28%. The grid is the 9 largest of 10 funds.\n Biotech ETFs, the share of each pair\u2019s weight held in the same companies. Read across or down; the number is the same either way. Cells are shaded against the closest pair here, 85%. Source: each fund\u2019s own filed or daily holdings, read by ETFIQ. IBB XBI FBT PBPH BBH PBE IBBQ BBP BBC \n IBB \u00b7 43% 44% 22% 65% 43% 85% 32% 12% \n XBI 43% \u00b7 26% 15% 22% 31% 43% 46% 31% \n FBT 44% 26% \u00b7 18% 41% 49% 33% 27% 0% \n PBPH 22% 15% 18% \u00b7 21% 18% 23% 11% 1% \n BBH 65% 22% 41% 21% \u00b7 43% 58% 20% 1% \n PBE 43% 31% 49% 18% 43% \u00b7 40% 30% 1% \n IBBQ 85% 43% 33% 23% 58% 40% \u00b7 33% 13% \n BBP 32% 46% 27% 11% 20% 30% 33% \u00b7 0% \n BBC 12% 31% 0% 1% 1% 1% 13% 0% \u00b7 \n \n Weight overlap adds the smaller of the two weights for every company both funds hold. Funds with a cut-short book are left out, not compared short.\n What each fund holds alone\n Biotech ETFs, the largest holding no other fund in the grid holds. Source: ETFIQ. Fund Largest holding it alone has Weight All of its own names \n IBB CYTEK BIOSCIENCES CTKB 0.1% 0.3% \n XBI HYPERLIQUID STRATEGIES PURR 0.6% 1.4% \n FBT NeoGenomics, Inc. NEO 3.3% 5.5% \n PBPH JOHNSON & JOHNSON JNJ 9.7% 48.1% \n BBH Iqvia Holdings Inc IQV 4.2% 5.6% \n IBBQ Amneal Pharmaceuticals Inc AMRX 0.5% 1.8% \n BBP CRINETICS PHARMACEUTICALS INC CRNX 3.3% 6.4% \n BBC ATAIBECKLEY INC ATAI 1.2% 12.5% \n \n Questions people ask\n How many biotech ETFs are there? ETFIQ covers 10 US listed biotech ETFs as of Nov 4, 2026. That is every one it can measure from the fund\u2019s own published holdings. What is the largest biotech ETF? IBB , iShares Biotechnology ETF, at $11.2bn in net assets as of Nov 3, 2026, the largest of the 10 biotech ETFs with a published size. What is the cheapest biotech ETF? PBPH , Portfolio Building Block World Pharma and Biotech Index ETF, at 0.13% a year by its prospectus filed Oct 27, 2025, the lowest fee of the 10 biotech ETFs that publish one. Which biotech ETF has performed best over the past year? XBI , State Street SPDR S&P Biotech ETF, at +47.9% total return over the year to Nov 4, 2026, the highest of the 8 biotech ETFs with a full year of trading behind them. Past returns do not predict future ones. What do biotech ETFs hold? Funds that hold drug developers, usually a broad basket of them rather than one field. Between them the 9 biotech ETFs ETFIQ can read name 48 companies in their ten largest holdings, by holdings dated Jul 31, 2026 to Nov 3, 2026, most widely AMGEN INC, which is among the ten largest of 7 of them. Do biotech ETFs hold the same companies? It depends which two. Across the 36 pairs of the 9 biotech ETFs with a full published book, by holdings dated Jul 31, 2026 to Nov 3, 2026, IBB and IBBQ hold 85% of their weight in the same companies, BBC and FBT hold 0%, and the middle pair holds 28%. Two funds sold on one theme are not the same fund. What the issuers say about this theme\n The issuers behind these biotech funds publish their own work on this theme. These are their pages and words, not ETFIQ\u2019s. A fund company writing about a theme it sells is making a case.\n Issuer material on this theme. Links leave ETFIQ. Source: each issuer\u2019s own site. Issuer What they publish Kind \n iShares iShares Portfolio Insights Their research index \n First Trust First Trust Investment Insights Their research index \n VanEck VanEck Insights Their research index \n Invesco Invesco insights Their research index \n \n Where to next\n The largest biotech ETFs The cheapest biotech ETFs The biotech ETFs least like the S&P 500 The biotech ETFs that returned most The most concentrated biotech ETFs Every thematic ETF Compare two funds The vocabulary State Street Investment Management: Industry & thematic ETF Sources\n Fund holdings from SEC Form N-PORT and from the issuers\u2019 own daily files SEC EDGAR, full-text search of fund filings SEC Form N-PORT, what a fund filed it holds Rule 19a-1, what a distribution notice must say Links are sources, not endorsements.\n ETFIQ is an independent publisher and makes no recommendations. Standards and sources \n Cite this page. ETFIQ, Biotech ETFs: what each one holds, data as of Nov 4, 2026. https://etfiq.com/themes/biotech Free to use with attribution for data ETFIQ computes; issuer data stays under its owner's terms. The underlying files are at Open data .\n Other forms Plain ETFIQ, Biotech ETFs: what each one holds, data as of Nov 4, 2026. https://etfiq.com/themes/biotech APA ETFIQ. (Nov 4, 2026). Biotech ETFs: what each one holds. Retrieved from https://etfiq.com/themes/biotech Markdown [Biotech ETFs: what each one holds (ETFIQ, Nov 4, 2026)](https://etfiq.com/themes/biotech)","source":"ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.","publisher":{"@id":"https://etfiq.com/#org","name":"ETFIQ","url":"https://etfiq.com"},"license":"https://etfiq.com/license/","license_text":"Data ETFIQ computes is free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms.","citation":"ETFIQ, Biotech ETFs: what each one holds, data as of Nov 4, 2026. https://etfiq.com/themes/biotech"}