# The therapeutics ETFs least like the S&P 500

> The therapeutics ETFs least like the S&P 500, ranked by the share of the fund by weight that is held in S&P 500 companies, as of Oct 20, 2026.

Data as of Oct 20, 2026. Rebuilt every trading night.

As of Oct 20, 2026 . Rebuilt every trading night.

## The therapeutics ETFs least like the S&P 500

See 5 funds ranked by the share of the fund by weight that is held in S&P 500 companies. Updated Oct 20, 2026. Every fund here is sold on therapeutics and medical devices, and they differ in how much of the index they hand you back. The one at the top is the one adding the most that is new.

| # | Ticker | Fund | Weight in S&P 500 companies | Active share | Net assets | Fee |
| --- | --- | --- | --- | --- | --- | --- |
| 1 | IBRN | iShares Neuroscience and Healthcare ETF | 5.3% | 100.0% | $6m | 0.47% |
| 2 | PSIL | AdvisorShares Psychedelics ETF | 7.8% | 98.4% | $46m | 1.00% |
| 3 | CANC | Tema Oncology ETF | 21.9% | 95.6% | $204m | 0.75% |
| 4 | MDEV | First Trust Indxx Medical Devices ETF | 47.4% | 98.0% | $3m | 0.70% |
| 5 | IHI | iShares U.S. Medical Devices ETF | 88.5% | 98.7% | $3.5bn | 0.37% |

### Method

The 5 of 5 ETFs in the therapeutics and medical devices theme with a filed book, least overlap first, each measured against the S&P 500 holdings ETFIQ reads for the same date. Across the funds listed here the weight held in S&P 500 companies runs from 5.3% to 88.5%. A thematic fund is worth its fee only for the part of it you do not already own. The list sorts one published figure, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.

### Where to next

### Where these figures came from

ETFIQ links to the documents behind every figure; a link is not an endorsement.

A ranking is not a recommendation or an opinion. ETFIQ is an independent publisher, not an adviser. Standards and sources

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Source: ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.
Cite: ETFIQ, The therapeutics ETFs least like the S&P 500, ranked by the share of the fund by weight that is held in S&P 500 companies, data as of Oct 20, 2026. https://etfiq.com/rankings/themes-off-index-therapeutics
Licence: https://etfiq.com/license/ Figures ETFIQ computes are free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms.
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