{"url":"https://etfiq.com/rankings/themes-off-index-therapeutics","section":"rankings","title":"The therapeutics ETFs least like the S&P 500 | ETFIQ","description":"The therapeutics ETFs least like the S&P 500, ranked by the share of the fund by weight that is held in S&P 500 companies, as of Oct 20, 2026.","as_of":"Oct 20, 2026","structured_data":[{"@type":"ItemList","name":"The therapeutics ETFs least like the S&P 500","numberOfItems":5,"itemListOrder":"https://schema.org/ItemListOrderDescending","itemListElement":[{"@type":"ListItem","position":1,"name":"IBRN","url":"https://etfiq.com/funds/ibrn"},{"@type":"ListItem","position":2,"name":"PSIL","url":"https://etfiq.com/funds/psil"},{"@type":"ListItem","position":3,"name":"CANC","url":"https://etfiq.com/funds/canc"},{"@type":"ListItem","position":4,"name":"MDEV","url":"https://etfiq.com/funds/mdev"},{"@type":"ListItem","position":5,"name":"IHI","url":"https://etfiq.com/funds/ihi"}]},{"@type":"Dataset","name":"The therapeutics ETFs least like the S&P 500","description":"The therapeutics ETFs least like the S&P 500, ranked by the share of the fund by weight that is held in S&P 500 companies, as of Oct 20, 2026.","url":"https://etfiq.com/rankings/themes-off-index-therapeutics","dateModified":"2026-10-20","creator":{"@id":"https://etfiq.com/#org"},"license":"https://etfiq.com/license/","isAccessibleForFree":true,"creditText":"ETFIQ (etfiq.com)","publisher":{"@id":"https://etfiq.com/#org"},"inLanguage":"en","creativeWorkStatus":"Published","distribution":[{"@type":"DataDownload","encodingFormat":"application/json","contentUrl":"https://etfiq.com/data/thematic.json"}],"variableMeasured":["Weight overlap with the S&P 500","Active share","Holdings","Top ten share of the fund","Total return","Fee for the differing part","Expense ratio"],"keywords":["exchange-traded funds","ETF","Thematic ETFs","fund data","SEC filings"]},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"ETFIQ","item":"https://etfiq.com/"},{"@type":"ListItem","position":2,"name":"Rankings","item":"https://etfiq.com/rankings/"},{"@type":"ListItem","position":3,"name":"The therapeutics ETFs least like the S&P 5...","item":"https://etfiq.com/rankings/themes-off-index-therapeutics"}]},{"@type":"WebPage","name":"The therapeutics ETFs least like the S&P 500","description":"The therapeutics ETFs least like the S&P 500, ranked by the share of the fund by weight that is held in S&P 500 companies, as of Oct 20, 2026.","url":"https://etfiq.com/rankings/themes-off-index-therapeutics","dateModified":"2026-10-20","isPartOf":{"@type":"WebSite","name":"ETFIQ","url":"https://etfiq.com"},"speakable":{"@type":"SpeakableSpecification","cssSelector":[".lede"]},"publisher":{"@id":"https://etfiq.com/#org"}}],"characters":3114,"truncated":false,"content":"ETFIQ / Rankings / The therapeutics ETFs least like the S&P 5... \n \n As of Oct 20, 2026 . Rebuilt every trading night.\n The therapeutics ETFs least like the S&P 500\n See 5 funds ranked by the share of the fund by weight that is held in S&P 500 companies. Updated Oct 20, 2026. Every fund here is sold on therapeutics and medical devices, and they differ in how much of the index they hand you back. The one at the top is the one adding the most that is new.\n The therapeutics ETFs least like the S&P 500, ranked by the share of the fund by weight that is held in S&P 500 companies, as of Oct 20, 2026. Source: ETFIQ. # Ticker Fund Weight in S&P 500 companies Active share Net assets Fee \n 1 IBRN iShares Neuroscience and Healthcare ETF 5.3% 100.0% $6m 0.47% \n 2 PSIL AdvisorShares Psychedelics ETF 7.8% 98.4% $46m 1.00% \n 3 CANC Tema Oncology ETF 21.9% 95.6% $204m 0.75% \n 4 MDEV First Trust Indxx Medical Devices ETF 47.4% 98.0% $3m 0.70% \n 5 IHI iShares U.S. Medical Devices ETF 88.5% 98.7% $3.5bn 0.37% \n \n Method\n The 5 of 5 ETFs in the therapeutics and medical devices theme with a filed book, least overlap first, each measured against the S&P 500 holdings ETFIQ reads for the same date. Across the funds listed here the weight held in S&P 500 companies runs from 5.3% to 88.5%. A thematic fund is worth its fee only for the part of it you do not already own. The list sorts one published figure, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.\n Where to next\n Every therapeutics and medical devices ETF and what it holds The largest therapeutics and medical devices ETFs Where these figures came from\n Fund holdings from SEC Form N-PORT and from the issuers own daily files SEC EDGAR, full-text search of fund filings SEC Form N-PORT, what a fund filed it holds Rule 19a-1, what a distribution notice must say ETFIQ links to the documents behind every figure; a link is not an endorsement.\n A ranking is not a recommendation or an opinion. ETFIQ is an independent publisher, not an adviser. Standards and sources \n Cite this page. ETFIQ, The therapeutics ETFs least like the S&P 500, ranked by the share of the fund by weight that is held in S&P 500 companies, data as of Oct 20, 2026. https://etfiq.com/rankings/themes-off-index-therapeutics Free to use with attribution for figures ETFIQ computes; issuer data stays under its owner's terms. The underlying files are at Open data .\n Other forms Plain ETFIQ, The therapeutics ETFs least like the S&P 500, ranked by the share of the fund by weight that is held in S&P 500 companies, data as of Oct 20, 2026. https://etfiq.com/rankings/themes-off-index-therapeutics APA ETFIQ. (Oct 20, 2026). The therapeutics ETFs least like the S&P 500, ranked by the share of the fund by weight that is held in S&P 500 companies. Retrieved from https://etfiq.com/rankings/themes-off-index-therapeutics Markdown [The therapeutics ETFs least like the S&P 500, ranked by the share of the fund by weight that is held in S&P 500 companies (ETFIQ, Oct 20, 2026)](https://etfiq.com/rankings/themes-off-index-therapeutics)","source":"ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.","publisher":{"@id":"https://etfiq.com/#org","name":"ETFIQ","url":"https://etfiq.com"},"license":"https://etfiq.com/license/","license_text":"Figures ETFIQ computes are free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms.","citation":"ETFIQ, The therapeutics ETFs least like the S&P 500, ranked by the share of the fund by weight that is held in S&P 500 companies, data as of Oct 20, 2026. https://etfiq.com/rankings/themes-off-index-therapeutics"}