# The innovation ETFs least like the S&P 500

> GXDW leads the innovation ETFs least like the S&P 500 at 0.0% (weight in S&P 500 companies), as of Nov 4, 2026. A ranking is not a recommendation.

Data as of Nov 4, 2026. Rebuilt every trading night.

As of Nov 4, 2026 . Rebuilt every trading night.

## The innovation ETFs least like the S&P 500

See 15 funds ranked by the share of each fund held in S&P 500 companies. Updated Nov 4, 2026. Every fund here is sold on innovation. The one at the top holds the least of the S&P 500, so it adds the most you do not already own.

| # | Ticker | Fund | Weight in S&P 500 companies | Active share | Net assets | Fee |
| --- | --- | --- | --- | --- | --- | --- |
| 1 | GXDW | Global X Dorsey Wright Thematic ETF | 0.0% | 100.0% | $6.0m | 0.50% |
| 2 | LFSC | F/m Emerald Life Sciences Innovation ETF | 0.0% | 100.0% | $126m | 0.54% |
| 3 | LENS | Sarmaya Thematic ETF | 16.0% | 98.9% | $67m | 0.79% |
| 4 | FMED | Fidelity Disruptive Medicine ETF | 21.8% | 97.5% | $52m | 0.50% |
| 5 | FITE | State Street SPDR S&P Kensho Future Secu | 26.9% | 95.3% | $153m | 0.45% |
| 6 | INVN | Alger Russell Innovation ETF | 32.5% | 98.5% | $9.6m | 0.55% |
| 7 | HTEC | ROBO Global Healthcare Technology and In | 32.7% | 97.9% | $69m | 0.68% |
| 8 | GTEK | Goldman Sachs Future Tech Leaders Equity | 33.0% | 96.5% | $209m | 0.75% |
| 9 | ARKK | ARK Innovation ETF | 36.2% | 85.7% | $5.9bn | 0.75% |
| 10 | BULD | Pacer BlueStar Engineering the Future ET | 36.4% | 97.3% | $8.6m | 0.49% |
| 11 | DTEC | ALPS Disruptive Technologies ETF | 41.3% | 93.5% | $78m | 0.50% |
| 12 | DTRE | First Trust Alerian Disruptive Technolog | 43.0% | 99.4% | $14m | 0.60% |
| 13 | FDFF | Fidelity Disruptive Finance ETF | 43.4% | 97.5% | $43m | 0.50% |
| 14 | QQQJ | Invesco NASDAQ Next Gen 100 ETF | 46.7% | 98.6% | $1.2bn | 0.15% |
| 15 | TMAT | Main Thematic Innovation ETF | 50.3% | 91.6% | $237m | 0.79% |

### Method

The 29 of 30 ETFs in the broad innovation and megatrends theme with a filed book, least overlap first, each measured against the S&P 500 holdings ETFIQ reads for the same date. Across the funds listed here the weight held in S&P 500 companies runs from 0.0% to 50.3%. A thematic fund is worth its fee only for the part of it you do not already own. The list sorts one published number, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.

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### Sources

Links are sources, not endorsements.

A ranking is not a recommendation or an opinion. ETFIQ is an independent publisher, not an adviser. Standards and sources

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Source: ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.
Cite: ETFIQ, The innovation ETFs least like the S&P 500, ranked by the share of each fund held in S&P 500 companies, data as of Nov 4, 2026. https://etfiq.com/rankings/themes-off-index-innovation
Licence: https://etfiq.com/license/ Data ETFIQ computes is free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms.
HTML: https://etfiq.com/rankings/themes-off-index-innovation