# The genomics ETFs least like the S&P 500

> ARKG leads the genomics ETFs least like the S&P 500 at 4.6% (weight in S&P 500 companies), as of Nov 4, 2026. 4 funds from ETFIQ’s own published data.

Data as of Nov 4, 2026. Rebuilt every trading night.

As of Nov 4, 2026 . Rebuilt every trading night.

## The genomics ETFs least like the S&P 500

See 4 funds ranked by the share of each fund held in S&P 500 companies. Updated Nov 4, 2026. Every fund here is sold on genomics. The one at the top holds the least of the S&P 500, so it adds the most you do not already own.

| # | Ticker | Fund | Weight in S&P 500 companies | Active share | Net assets | Fee |
| --- | --- | --- | --- | --- | --- | --- |
| 1 | ARKG | ARK Genomic Revolution ETF | 4.6% | 98.5% | $2.1bn | 0.75% |
| 2 | GNOM | Global X Genomics & Biotechnology ETF | 21.0% | 97.6% | $104m | 0.50% |
| 3 | IDNA | iShares Genomics Immunology and Healthca | 27.4% | 99.1% | $340m | 0.47% |
| 4 | GNMX | Corgi Genomics & Precision Medicine ETF | 31.0% | 99.4% | $1.3m | 0.35% |

### Method

The 4 of 4 ETFs in the genomics and gene editing theme with a filed book, least overlap first, each measured against the S&P 500 holdings ETFIQ reads for the same date. Across the funds listed here the weight held in S&P 500 companies runs from 4.6% to 31.0%. A thematic fund is worth its fee only for the part of it you do not already own. The list sorts one published number, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.

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### Sources

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A ranking is not a recommendation or an opinion. ETFIQ is an independent publisher, not an adviser. Standards and sources

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Source: ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.
Cite: ETFIQ, The genomics ETFs least like the S&P 500, ranked by the share of each fund held in S&P 500 companies, data as of Nov 4, 2026. https://etfiq.com/rankings/themes-off-index-genomics
Licence: https://etfiq.com/license/ Data ETFIQ computes is free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms.
HTML: https://etfiq.com/rankings/themes-off-index-genomics