{"url":"https://etfiq.com/rankings/themes-off-index-biotech","section":"rankings","title":"The biotech ETFs least like the S&P 500 | ETFIQ","description":"BBC leads the biotech ETFs least like the S&P 500 at 0.0% (weight in S&P 500 companies), as of Nov 4, 2026. 9 funds from ETFIQ\u2019s own published data.","as_of":"Nov 4, 2026","structured_data":[{"@type":"ItemList","name":"The biotech ETFs least like the S&P 500","numberOfItems":9,"itemListOrder":"https://schema.org/ItemListOrderDescending","itemListElement":[{"@type":"ListItem","position":1,"name":"BBC","url":"https://etfiq.com/funds/bbc"},{"@type":"ListItem","position":2,"name":"BBP","url":"https://etfiq.com/funds/bbp"},{"@type":"ListItem","position":3,"name":"XBI","url":"https://etfiq.com/funds/xbi"},{"@type":"ListItem","position":4,"name":"FBT","url":"https://etfiq.com/funds/fbt"},{"@type":"ListItem","position":5,"name":"PBE","url":"https://etfiq.com/funds/pbe"},{"@type":"ListItem","position":6,"name":"IBB","url":"https://etfiq.com/funds/ibb"},{"@type":"ListItem","position":7,"name":"IBBQ","url":"https://etfiq.com/funds/ibbq"},{"@type":"ListItem","position":8,"name":"PBPH","url":"https://etfiq.com/funds/pbph"},{"@type":"ListItem","position":9,"name":"BBH","url":"https://etfiq.com/funds/bbh"}]},{"@type":"Dataset","name":"The biotech ETFs least like the S&P 500","description":"BBC leads the biotech ETFs least like the S&P 500 at 0.0% (weight in S&P 500 companies), as of Nov 4, 2026. 9 funds from ETFIQ\u2019s own published data.","url":"https://etfiq.com/rankings/themes-off-index-biotech","dateModified":"2026-11-04","creator":{"@id":"https://etfiq.com/#org"},"license":"https://etfiq.com/license/","isAccessibleForFree":true,"creditText":"ETFIQ (etfiq.com)","publisher":{"@id":"https://etfiq.com/#org"},"inLanguage":"en","creativeWorkStatus":"Published","distribution":[{"@type":"DataDownload","encodingFormat":"application/json","contentUrl":"https://etfiq.com/data/thematic.json"}],"variableMeasured":["Weight overlap with the S&P 500","Active share","Holdings","Top ten share of the fund","Total return","Fee for the differing part","Expense ratio"],"keywords":["exchange-traded funds","ETF","Thematic ETFs","fund data","SEC filings"]},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"ETFIQ","item":"https://etfiq.com/"},{"@type":"ListItem","position":2,"name":"Rankings","item":"https://etfiq.com/rankings/"},{"@type":"ListItem","position":3,"name":"The biotech ETFs least like the S&P 500","item":"https://etfiq.com/rankings/themes-off-index-biotech"}]},{"@type":"WebPage","name":"The biotech ETFs least like the S&P 500","description":"BBC leads the biotech ETFs least like the S&P 500 at 0.0% (weight in S&P 500 companies), as of Nov 4, 2026. 9 funds from ETFIQ\u2019s own published data.","url":"https://etfiq.com/rankings/themes-off-index-biotech","dateModified":"2026-11-04","isPartOf":{"@type":"WebSite","name":"ETFIQ","url":"https://etfiq.com"},"speakable":{"@type":"SpeakableSpecification","cssSelector":[".lede"]},"publisher":{"@id":"https://etfiq.com/#org"}}],"characters":3080,"truncated":false,"content":"ETFIQ / Rankings / The biotech ETFs least like the S&P 500 \n \n As of Nov 4, 2026 . Rebuilt every trading night.\n The biotech ETFs least like the S&P 500\n See 9 funds ranked by the share of each fund held in S&P 500 companies. Updated Nov 4, 2026. Every fund here is sold on biotech. The one at the top holds the least of the S&P 500, so it adds the most you do not already own.\n The biotech ETFs least like the S&P 500, ranked by the share of each fund held in S&P 500 companies, as of Nov 4, 2026. Source: ETFIQ. # Ticker Fund Weight in S&P 500 companies Active share Net assets Fee \n 1 BBC Virtus Biotech Clinical Trials ETF 0.0% 100.0% $46m 0.65% \n 2 BBP Virtus Biotech ETF 10.5% 99.0% $99m 0.34% \n 3 XBI State Street SPDR S&P Biotech ETF 13.9% 98.4% $10.6bn 0.35% \n 4 FBT First Trust NYSE Arca Biotechnology Inde 24.8% 99.1% $3.1bn 0.55% \n 5 PBE Invesco Biotechnology & Genome ETF 32.3% 99.0% $442m 0.59% \n 6 IBB iShares Biotechnology ETF 42.0% 99.0% $11.2bn 0.44% \n 7 IBBQ Invesco Nasdaq Biotechnology ETF 42.5% 99.0% $121m 0.19% \n 8 PBPH Portfolio Building Block World Pharma an 59.2% 95.0% $952m 0.13% \n 9 BBH VanEck Biotech ETF 64.4% 99.0% $525m 0.35% \n \n Method\n The 9 of 10 ETFs in the biotech theme with a filed book, least overlap first, each measured against the S&P 500 holdings ETFIQ reads for the same date. Across the funds listed here the weight held in S&P 500 companies runs from 0.0% to 64.4%. A thematic fund is worth its fee only for the part of it you do not already own. The list sorts one published number, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.\n Where to next\n Every biotech ETF and what it holds The largest biotech ETFs Sources\n Fund holdings from SEC Form N-PORT and from the issuers\u2019 own daily files SEC EDGAR, full-text search of fund filings SEC Form N-PORT, what a fund filed it holds Rule 19a-1, what a distribution notice must say Links are sources, not endorsements.\n A ranking is not a recommendation or an opinion. ETFIQ is an independent publisher, not an adviser. Standards and sources \n Cite this page. ETFIQ, The biotech ETFs least like the S&P 500, ranked by the share of each fund held in S&P 500 companies, data as of Nov 4, 2026. https://etfiq.com/rankings/themes-off-index-biotech Free to use with attribution for data ETFIQ computes; issuer data stays under its owner's terms. The underlying files are at Open data .\n Other forms Plain ETFIQ, The biotech ETFs least like the S&P 500, ranked by the share of each fund held in S&P 500 companies, data as of Nov 4, 2026. https://etfiq.com/rankings/themes-off-index-biotech APA ETFIQ. (Nov 4, 2026). The biotech ETFs least like the S&P 500, ranked by the share of each fund held in S&P 500 companies. Retrieved from https://etfiq.com/rankings/themes-off-index-biotech Markdown [The biotech ETFs least like the S&P 500, ranked by the share of each fund held in S&P 500 companies (ETFIQ, Nov 4, 2026)](https://etfiq.com/rankings/themes-off-index-biotech)","source":"ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.","publisher":{"@id":"https://etfiq.com/#org","name":"ETFIQ","url":"https://etfiq.com"},"license":"https://etfiq.com/license/","license_text":"Data ETFIQ computes is free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms.","citation":"ETFIQ, The biotech ETFs least like the S&P 500, ranked by the share of each fund held in S&P 500 companies, data as of Nov 4, 2026. https://etfiq.com/rankings/themes-off-index-biotech"}