# The thematic ETFs least like the S&P 500

> PDBA leads the thematic ETFs least like the S&P 500 at 100.0% (active share, latest holdings filing), as of Oct 27, 2026.

Data as of Oct 27, 2026. Rebuilt every trading night.

As of Oct 27, 2026 . Rebuilt every trading night.

## The thematic ETFs least like the S&P 500

See 15 funds ranked by active share against the S&P 500, latest holdings filing. Updated Oct 27, 2026. Different is not better. It is how much of the fund a holder did not already own through the index. The top 15 are level at 100.0%, so their order is not a ranking. None of them holds anything the S&P 500 holds.

| # | Ticker | Fund | Theme | Active share | In the S&P 500 | Total return 1Y | vs its benchmark 1Y |
| --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | PDBA | Invesco Agriculture Commodity Strategy No K-1 ETF | Agriculture | 100.0% | 0.0% | +8.2% | not measured |
| 2 | DRAI | Draco Evolution AI ETF | Artificial intelligence | 100.0% | 0.0% | +7.5% | −5.4 pts vs GUSA |
| 3 | DRGN | Themes China Generative Artificial Intelligence ETF | Artificial intelligence | 100.0% | 0.0% | −20.7% | −33.8 pts vs ACWI |
| 4 | KAIT | KraneShares Asia AI Technology ETF | Artificial intelligence | 100.0% | 0.0% | not published | not available |
| 5 | BBC | Virtus Biotech Clinical Trials ETF | Biotech | 100.0% | 0.0% | +36.6% | not measured |
| 6 | GXDW | Global X Dorsey Wright Thematic ETF | Broad innovation and megatrends | 100.0% | 0.0% | −10.8% | not measured |
| 7 | LFSC | F/m Emerald Life Sciences Innovation ETF | Broad innovation and megatrends | 100.0% | 0.0% | +35.8% | +22.7 pts vs IWV |
| 8 | MJ | Amplify Alternative Harvest ETF | Cannabis | 100.0% | 0.0% | −32.6% | not measured |
| 9 | MSOS | AdvisorShares Pure US Cannabis ETF | Cannabis | 100.0% | 0.0% | −12.0% | not measured |
| 10 | WEED | Roundhill Cannabis ETF | Cannabis | 100.0% | 0.0% | −1.5% | not measured |
| 11 | YOLO | AdvisorShares Pure Cannabis ETF | Cannabis | 100.0% | 0.0% | −21.1% | not measured |
| 12 | CTEC | Global X ClimateTech ETF | Clean energy | 100.0% | 7.1% | −10.0% | not measured |
| 13 | ICLN | iShares Global Clean Energy ETF | Clean energy | 100.0% | 8.2% | −4.3% | not measured |
| 14 | KGRN | KraneShares MSCI China Clean Technology Index ETF | Clean energy | 100.0% | 0.0% | −30.9% | not measured |
| 15 | RNRG | Global X Renewable Energy Producers ETF | Clean energy | 100.0% | 0.0% | −5.1% | −18.2 pts vs ACWI |

### Method

Active share is one hundred minus the weight overlap with the S&P 500 book, computed by ETFIQ from filed holdings. The list sorts one published number, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.

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### Sources

Links are sources, not endorsements.

A ranking is not a recommendation or an opinion. ETFIQ is an independent publisher, not an adviser. Standards and sources

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Source: ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.
Cite: ETFIQ, The thematic ETFs least like the S&P 500, ranked by active share against the S&P 500, data as of Oct 27, 2026. https://etfiq.com/rankings/themes-least-index
Licence: https://etfiq.com/license/ Data ETFIQ computes is free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms.
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