# The largest therapeutics and medical devices ETFs

> The largest therapeutics and medical devices ETFs, ranked by net assets, as of Oct 20, 2026. 5 funds from ETFIQ’s own published figures.

Data as of Oct 20, 2026. Rebuilt every trading night.

As of Oct 20, 2026 . Rebuilt every trading night.

## The largest therapeutics and medical devices ETFs

See 5 funds ranked by net assets. Updated Oct 20, 2026. Every fund here is sold on therapeutics and medical devices. What each one holds, and how much of it the S&P 500 already holds for you, is the column beside the size.

| # | Ticker | Fund | Net assets | Weight in S&P 500 companies | Total return, 1Y | Fee | Source |
| --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | IHI | iShares U.S. Medical Devices ETF | $3.5bn | 88.5% | −10.1% | 0.37% | Issuer daily, Oct 20, 2026 |
| 2 | CANC | Tema Oncology ETF | $204m | 21.9% | +36.5% | 0.75% | Issuer page, Oct 19, 2026 |
| 3 | PSIL | AdvisorShares Psychedelics ETF | $46m | 7.8% | +7.0% | 1.00% | Issuer page, Oct 20, 2026 |
| 4 | IBRN | iShares Neuroscience and Healthcare ETF | $6m | 5.3% | +9.3% | 0.47% | Issuer daily, Oct 20, 2026 |
| 5 | MDEV | First Trust Indxx Medical Devices ETF | $3m | 47.4% | +4.4% | 0.70% | Issuer page, Oct 20, 2026 |

### Method

The 5 ETFs in the therapeutics and medical devices theme, of which 5 publish net assets, ranked on the most recent figure for each. Across the funds listed here the weight held in S&P 500 companies runs from 5.3% to 88.5%. Size shows where the money is, not what a fund did. The list sorts one published figure, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.

### Where to next

### Where these figures came from

ETFIQ links to the documents behind every figure; a link is not an endorsement.

A ranking is not a recommendation or an opinion. ETFIQ is an independent publisher, not an adviser. Standards and sources

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Source: ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.
Cite: ETFIQ, The largest therapeutics and medical devices ETFs, ranked by net assets, data as of Oct 20, 2026. https://etfiq.com/rankings/themes-largest-therapeutics
Licence: https://etfiq.com/license/ Figures ETFIQ computes are free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms.
HTML: https://etfiq.com/rankings/themes-largest-therapeutics