# The largest healthcare innovation ETFs

> OZEM leads the largest healthcare innovation ETFs at $54m (net assets), as of Oct 27, 2026. The largest healthcare innovation ETFs, ranked by net assets.

Data as of Oct 27, 2026. Rebuilt every trading night.

As of Oct 27, 2026 . Rebuilt every trading night.

## The largest healthcare innovation ETFs

See 8 funds ranked by net assets. Updated Oct 27, 2026. Every fund here is sold on healthcare innovation. The column beside the size shows how much of each the S&P 500 already holds.

| # | Ticker | Fund | Net assets | Weight in S&P 500 companies | Total return, 1Y | Fee | Source |
| --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | OZEM | Roundhill GLP-1 & Weight Loss ETF | $54m | 30.1% | +6.8% | 0.59% | Issuer daily, Oct 27, 2026 |
| 2 | HELX | Franklin Genomic Advancements ETF | $35m | 14.9% | +28.9% | 0.50% | Issuer page, Oct 26, 2026 |
| 3 | HEAL | Global X HealthTech ETF | $31m | 28.8% | −6.4% | 0.50% | Issuer page, Oct 12, 2026 |
| 4 | BMED | iShares Health Innovation Active ETF | $14m | 57.7% | +24.8% | 0.55% | Issuer daily, Oct 27, 2026 |
| 5 | EKG | First Trust Nasdaq Lux Digital Health So | $9.6m | 40.5% | +31.1% | 0.65% | Issuer page, Oct 26, 2026 |
| 6 | THNR | Amplify Weight Loss Drug & Treatment ETF | $5.7m | 45.1% | +8.1% | 0.59% | Issuer page, Oct 26, 2026 |
| 7 | WDNA | WisdomTree BioRevolution Fund | $2.7m | 25.9% | +44.5% | 0.45% | SEC filing, Jun 30, 2026 |
| 8 | LGHT | Langar Global HealthTech ETF | $2.5m | 57.9% | +4.3% | 0.85% | SEC filing, Jun 30, 2026 |

### Method

The 8 ETFs in the healthcare innovation and glp-1 theme, of which 8 publish net assets, ranked on the most recent number for each. Across the funds listed here the weight held in S&P 500 companies runs from 14.9% to 57.9%. Size shows where the money is, not what a fund did. The list sorts one published number, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.

### Where to next

### Sources

Links are sources, not endorsements.

A ranking is not a recommendation or an opinion. ETFIQ is an independent publisher, not an adviser. Standards and sources

---

Source: ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.
Cite: ETFIQ, The largest healthcare innovation ETFs, ranked by net assets, data as of Oct 27, 2026. https://etfiq.com/rankings/themes-largest-health-innovation
Licence: https://etfiq.com/license/ Data ETFIQ computes is free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms.
HTML: https://etfiq.com/rankings/themes-largest-health-innovation