{"url":"https://etfiq.com/rankings/themes-largest-health-innovation","section":"rankings","title":"The largest healthcare innovation ETFs | ETFIQ","description":"OZEM leads the largest healthcare innovation ETFs at $54m (net assets), as of Oct 27, 2026. The largest healthcare innovation ETFs, ranked by net assets.","as_of":"Oct 27, 2026","structured_data":[{"@type":"ItemList","name":"The largest healthcare innovation ETFs","numberOfItems":8,"itemListOrder":"https://schema.org/ItemListOrderDescending","itemListElement":[{"@type":"ListItem","position":1,"name":"OZEM","url":"https://etfiq.com/funds/ozem"},{"@type":"ListItem","position":2,"name":"HELX","url":"https://etfiq.com/funds/helx"},{"@type":"ListItem","position":3,"name":"HEAL","url":"https://etfiq.com/funds/heal"},{"@type":"ListItem","position":4,"name":"BMED","url":"https://etfiq.com/funds/bmed"},{"@type":"ListItem","position":5,"name":"EKG","url":"https://etfiq.com/funds/ekg"},{"@type":"ListItem","position":6,"name":"THNR","url":"https://etfiq.com/funds/thnr"},{"@type":"ListItem","position":7,"name":"WDNA","url":"https://etfiq.com/funds/wdna"},{"@type":"ListItem","position":8,"name":"LGHT","url":"https://etfiq.com/funds/lght"}]},{"@type":"Dataset","name":"The largest healthcare innovation ETFs","description":"OZEM leads the largest healthcare innovation ETFs at $54m (net assets), as of Oct 27, 2026. The largest healthcare innovation ETFs, ranked by net assets.","url":"https://etfiq.com/rankings/themes-largest-health-innovation","dateModified":"2026-10-27","creator":{"@id":"https://etfiq.com/#org"},"license":"https://etfiq.com/license/","isAccessibleForFree":true,"creditText":"ETFIQ (etfiq.com)","publisher":{"@id":"https://etfiq.com/#org"},"inLanguage":"en","creativeWorkStatus":"Published","distribution":[{"@type":"DataDownload","encodingFormat":"application/json","contentUrl":"https://etfiq.com/data/thematic.json"}],"variableMeasured":["Weight overlap with the S&P 500","Active share","Holdings","Top ten share of the fund","Total return","Fee for the differing part","Expense ratio"],"keywords":["exchange-traded funds","ETF","Thematic ETFs","fund data","SEC filings"]},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"ETFIQ","item":"https://etfiq.com/"},{"@type":"ListItem","position":2,"name":"Rankings","item":"https://etfiq.com/rankings/"},{"@type":"ListItem","position":3,"name":"The largest healthcare innovation ETFs","item":"https://etfiq.com/rankings/themes-largest-health-innovation"}]},{"@type":"WebPage","name":"The largest healthcare innovation ETFs","description":"OZEM leads the largest healthcare innovation ETFs at $54m (net assets), as of Oct 27, 2026. The largest healthcare innovation ETFs, ranked by net assets.","url":"https://etfiq.com/rankings/themes-largest-health-innovation","dateModified":"2026-10-27","isPartOf":{"@type":"WebSite","name":"ETFIQ","url":"https://etfiq.com"},"speakable":{"@type":"SpeakableSpecification","cssSelector":[".lede"]},"publisher":{"@id":"https://etfiq.com/#org"}}],"characters":3037,"truncated":false,"content":"ETFIQ / Rankings / The largest healthcare innovation ETFs \n \n As of Oct 27, 2026 . Rebuilt every trading night.\n The largest healthcare innovation ETFs\n See 8 funds ranked by net assets. Updated Oct 27, 2026. Every fund here is sold on healthcare innovation. The column beside the size shows how much of each the S&P 500 already holds.\n The largest healthcare innovation ETFs, ranked by net assets, as of Oct 27, 2026. Source: ETFIQ. # Ticker Fund Net assets Weight in S&P 500 companies Total return, 1Y Fee Source \n 1 OZEM Roundhill GLP-1 & Weight Loss ETF $54m 30.1% +6.8% 0.59% Issuer daily, Oct 27, 2026 \n 2 HELX Franklin Genomic Advancements ETF $35m 14.9% +28.9% 0.50% Issuer page, Oct 26, 2026 \n 3 HEAL Global X HealthTech ETF $31m 28.8% \u22126.4% 0.50% Issuer page, Oct 12, 2026 \n 4 BMED iShares Health Innovation Active ETF $14m 57.7% +24.8% 0.55% Issuer daily, Oct 27, 2026 \n 5 EKG First Trust Nasdaq Lux Digital Health So $9.6m 40.5% +31.1% 0.65% Issuer page, Oct 26, 2026 \n 6 THNR Amplify Weight Loss Drug & Treatment ETF $5.7m 45.1% +8.1% 0.59% Issuer page, Oct 26, 2026 \n 7 WDNA WisdomTree BioRevolution Fund $2.7m 25.9% +44.5% 0.45% SEC filing, Jun 30, 2026 \n 8 LGHT Langar Global HealthTech ETF $2.5m 57.9% +4.3% 0.85% SEC filing, Jun 30, 2026 \n \n Method\n The 8 ETFs in the healthcare innovation and glp-1 theme, of which 8 publish net assets, ranked on the most recent number for each. Across the funds listed here the weight held in S&P 500 companies runs from 14.9% to 57.9%. Size shows where the money is, not what a fund did. The list sorts one published number, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.\n Where to next\n Every healthcare innovation ETF and what it holds The thematic ETFs least like the S&P 500 Sources\n Fund holdings from SEC Form N-PORT and from the issuers\u2019 own daily files SEC EDGAR, full-text search of fund filings SEC Form N-PORT, what a fund filed it holds Rule 19a-1, what a distribution notice must say Links are sources, not endorsements.\n A ranking is not a recommendation or an opinion. ETFIQ is an independent publisher, not an adviser. Standards and sources \n Cite this page. ETFIQ, The largest healthcare innovation ETFs, ranked by net assets, data as of Oct 27, 2026. https://etfiq.com/rankings/themes-largest-health-innovation Free to use with attribution for data ETFIQ computes; issuer data stays under its owner's terms. The underlying files are at Open data .\n Other forms Plain ETFIQ, The largest healthcare innovation ETFs, ranked by net assets, data as of Oct 27, 2026. https://etfiq.com/rankings/themes-largest-health-innovation APA ETFIQ. (Oct 27, 2026). The largest healthcare innovation ETFs, ranked by net assets. Retrieved from https://etfiq.com/rankings/themes-largest-health-innovation Markdown [The largest healthcare innovation ETFs, ranked by net assets (ETFIQ, Oct 27, 2026)](https://etfiq.com/rankings/themes-largest-health-innovation)","source":"ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.","publisher":{"@id":"https://etfiq.com/#org","name":"ETFIQ","url":"https://etfiq.com"},"license":"https://etfiq.com/license/","license_text":"Data ETFIQ computes is free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms.","citation":"ETFIQ, The largest healthcare innovation ETFs, ranked by net assets, data as of Oct 27, 2026. https://etfiq.com/rankings/themes-largest-health-innovation"}