# Biotech ETFs: 10 Ranked by Net Assets, Nov 2026

> 10 biotech ETFs ranked by net assets, as of Nov 4, 2026. IBB leads at $11.2bn in net assets. XBI is second at $10.6bn in net assets.

Data as of Nov 4, 2026. Rebuilt every trading night.

As of Nov 4, 2026 . Rebuilt every trading night.

## The largest biotech ETFs

See 10 funds ranked by net assets. Updated Nov 4, 2026. Every fund here is sold on biotech. The column beside the size shows how much of each the S&P 500 already holds.

| # | Ticker | Fund | Net assets | Weight in S&P 500 companies | Total return, 1Y | Fee | Source |
| --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | IBB | iShares Biotechnology ETF | $11.2bn | 42.0% | +42.0% | 0.44% | Issuer daily, Nov 3, 2026 |
| 2 | XBI | State Street SPDR S&P Biotech ETF | $10.6bn | 13.9% | +47.9% | 0.35% | Issuer daily, Nov 3, 2026 |
| 3 | FBT | First Trust NYSE Arca Biotechnology Inde | $3.1bn | 24.8% | +47.0% | 0.55% | Issuer page, Nov 3, 2026 |
| 4 | PBPH | Portfolio Building Block World Pharma an | $952m | 59.2% | too new | 0.13% | SEC filing, Jul 31, 2026 |
| 5 | BBH | VanEck Biotech ETF | $525m | 64.4% | +47.2% | 0.35% | Issuer holdings, Nov 3, 2026 |
| 6 | PBE | Invesco Biotechnology & Genome ETF | $442m | 32.3% | +44.2% | 0.59% | Issuer page, Nov 3, 2026 |
| 7 | IBBQ | Invesco Nasdaq Biotechnology ETF | $121m | 42.5% | +42.7% | 0.19% | Issuer page, Nov 3, 2026 |
| 8 | BBP | Virtus Biotech ETF | $99m | 10.5% | +44.4% | 0.34% | SEC filing, Jul 31, 2026 |
| 9 | BBC | Virtus Biotech Clinical Trials ETF | $46m | 0.0% | +45.9% | 0.65% | SEC filing, Jul 31, 2026 |
| 10 | TDNA | T. Rowe Price Biotech ETF | $11m | not yet filed | too new | 0.55% | Issuer page, Nov 3, 2026 |

### Method

The 10 ETFs in the biotech theme, of which 10 publish net assets, ranked on the most recent number for each. Across the funds listed here the weight held in S&P 500 companies runs from 0.0% to 64.4%. Size shows where the money is, not what a fund did. The list sorts one published number, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.

### Where to next

### Sources

Links are sources, not endorsements.

A ranking is not a recommendation or an opinion. ETFIQ is an independent publisher, not an adviser. Standards and sources

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Source: ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.
Cite: ETFIQ, The largest biotech ETFs, ranked by net assets, data as of Nov 4, 2026. https://etfiq.com/rankings/themes-largest-biotech
Licence: https://etfiq.com/license/ Data ETFIQ computes is free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms.
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