{"url":"https://etfiq.com/rankings/themes-largest-biotech","section":"rankings","title":"Biotech ETFs: 10 Ranked by Net Assets, Nov 2026 | ETFIQ","description":"10 biotech ETFs ranked by net assets, as of Nov 4, 2026. IBB leads at $11.2bn in net assets. XBI is second at $10.6bn in net assets.","as_of":"Nov 4, 2026","structured_data":[{"@type":"ItemList","name":"The largest biotech ETFs","numberOfItems":10,"itemListOrder":"https://schema.org/ItemListOrderDescending","itemListElement":[{"@type":"ListItem","position":1,"name":"IBB","url":"https://etfiq.com/funds/ibb"},{"@type":"ListItem","position":2,"name":"XBI","url":"https://etfiq.com/funds/xbi"},{"@type":"ListItem","position":3,"name":"FBT","url":"https://etfiq.com/funds/fbt"},{"@type":"ListItem","position":4,"name":"PBPH","url":"https://etfiq.com/funds/pbph"},{"@type":"ListItem","position":5,"name":"BBH","url":"https://etfiq.com/funds/bbh"},{"@type":"ListItem","position":6,"name":"PBE","url":"https://etfiq.com/funds/pbe"},{"@type":"ListItem","position":7,"name":"IBBQ","url":"https://etfiq.com/funds/ibbq"},{"@type":"ListItem","position":8,"name":"BBP","url":"https://etfiq.com/funds/bbp"},{"@type":"ListItem","position":9,"name":"BBC","url":"https://etfiq.com/funds/bbc"},{"@type":"ListItem","position":10,"name":"TDNA","url":"https://etfiq.com/funds/tdna"}]},{"@type":"Dataset","name":"The largest biotech ETFs","description":"10 biotech ETFs ranked by net assets, as of Nov 4, 2026. IBB leads at $11.2bn in net assets. XBI is second at $10.6bn in net assets.","url":"https://etfiq.com/rankings/themes-largest-biotech","dateModified":"2026-11-04","creator":{"@id":"https://etfiq.com/#org"},"license":"https://etfiq.com/license/","isAccessibleForFree":true,"creditText":"ETFIQ (etfiq.com)","publisher":{"@id":"https://etfiq.com/#org"},"inLanguage":"en","creativeWorkStatus":"Published","distribution":[{"@type":"DataDownload","encodingFormat":"application/json","contentUrl":"https://etfiq.com/data/thematic.json"}],"variableMeasured":["Weight overlap with the S&P 500","Active share","Holdings","Top ten share of the fund","Total return","Fee for the differing part","Expense ratio"],"keywords":["exchange-traded funds","ETF","Thematic ETFs","fund data","SEC filings"]},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"ETFIQ","item":"https://etfiq.com/"},{"@type":"ListItem","position":2,"name":"Rankings","item":"https://etfiq.com/rankings/"},{"@type":"ListItem","position":3,"name":"The largest biotech ETFs","item":"https://etfiq.com/rankings/themes-largest-biotech"}]},{"@type":"WebPage","name":"Biotech ETFs: 10 Ranked by Net Assets, Nov 2026","description":"10 biotech ETFs ranked by net assets, as of Nov 4, 2026. IBB leads at $11.2bn in net assets. XBI is second at $10.6bn in net assets.","url":"https://etfiq.com/rankings/themes-largest-biotech","dateModified":"2026-11-04","isPartOf":{"@type":"WebSite","name":"ETFIQ","url":"https://etfiq.com"},"speakable":{"@type":"SpeakableSpecification","cssSelector":[".lede"]},"publisher":{"@id":"https://etfiq.com/#org"}}],"characters":3011,"truncated":false,"content":"ETFIQ / Rankings / The largest biotech ETFs \n \n As of Nov 4, 2026 . Rebuilt every trading night.\n The largest biotech ETFs\n See 10 funds ranked by net assets. Updated Nov 4, 2026. Every fund here is sold on biotech. The column beside the size shows how much of each the S&P 500 already holds.\n The largest biotech ETFs, ranked by net assets, as of Nov 4, 2026. Source: ETFIQ. # Ticker Fund Net assets Weight in S&P 500 companies Total return, 1Y Fee Source \n 1 IBB iShares Biotechnology ETF $11.2bn 42.0% +42.0% 0.44% Issuer daily, Nov 3, 2026 \n 2 XBI State Street SPDR S&P Biotech ETF $10.6bn 13.9% +47.9% 0.35% Issuer daily, Nov 3, 2026 \n 3 FBT First Trust NYSE Arca Biotechnology Inde $3.1bn 24.8% +47.0% 0.55% Issuer page, Nov 3, 2026 \n 4 PBPH Portfolio Building Block World Pharma an $952m 59.2% too new 0.13% SEC filing, Jul 31, 2026 \n 5 BBH VanEck Biotech ETF $525m 64.4% +47.2% 0.35% Issuer holdings, Nov 3, 2026 \n 6 PBE Invesco Biotechnology & Genome ETF $442m 32.3% +44.2% 0.59% Issuer page, Nov 3, 2026 \n 7 IBBQ Invesco Nasdaq Biotechnology ETF $121m 42.5% +42.7% 0.19% Issuer page, Nov 3, 2026 \n 8 BBP Virtus Biotech ETF $99m 10.5% +44.4% 0.34% SEC filing, Jul 31, 2026 \n 9 BBC Virtus Biotech Clinical Trials ETF $46m 0.0% +45.9% 0.65% SEC filing, Jul 31, 2026 \n 10 TDNA T. Rowe Price Biotech ETF $11m not yet filed too new 0.55% Issuer page, Nov 3, 2026 \n \n Method\n The 10 ETFs in the biotech theme, of which 10 publish net assets, ranked on the most recent number for each. Across the funds listed here the weight held in S&P 500 companies runs from 0.0% to 64.4%. Size shows where the money is, not what a fund did. The list sorts one published number, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.\n Where to next\n Every biotech ETF and what it holds The thematic ETFs least like the S&P 500 Sources\n Fund holdings from SEC Form N-PORT and from the issuers\u2019 own daily files SEC EDGAR, full-text search of fund filings SEC Form N-PORT, what a fund filed it holds Rule 19a-1, what a distribution notice must say Links are sources, not endorsements.\n A ranking is not a recommendation or an opinion. ETFIQ is an independent publisher, not an adviser. Standards and sources \n Cite this page. ETFIQ, The largest biotech ETFs, ranked by net assets, data as of Nov 4, 2026. https://etfiq.com/rankings/themes-largest-biotech Free to use with attribution for data ETFIQ computes; issuer data stays under its owner's terms. The underlying files are at Open data .\n Other forms Plain ETFIQ, The largest biotech ETFs, ranked by net assets, data as of Nov 4, 2026. https://etfiq.com/rankings/themes-largest-biotech APA ETFIQ. (Nov 4, 2026). The largest biotech ETFs, ranked by net assets. Retrieved from https://etfiq.com/rankings/themes-largest-biotech Markdown [The largest biotech ETFs, ranked by net assets (ETFIQ, Nov 4, 2026)](https://etfiq.com/rankings/themes-largest-biotech)","source":"ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.","publisher":{"@id":"https://etfiq.com/#org","name":"ETFIQ","url":"https://etfiq.com"},"license":"https://etfiq.com/license/","license_text":"Data ETFIQ computes is free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms.","citation":"ETFIQ, The largest biotech ETFs, ranked by net assets, data as of Nov 4, 2026. https://etfiq.com/rankings/themes-largest-biotech"}