# Biotech ETFs: 9 Ranked by Top-10 Weight, Nov 2026

> 9 biotech ETFs ranked by weight in their ten largest holdings, as of Nov 4, 2026. BBH leads at 73.5% in its ten largest. Rebuilt every trading night.

Data as of Nov 4, 2026. Rebuilt every trading night.

As of Nov 4, 2026 . Rebuilt every trading night.

## The most concentrated biotech ETFs

See 9 funds ranked by the share of the fund held in its ten largest positions. Updated Nov 4, 2026. Two funds on one theme can hold ten names or two hundred. Fund names do not show which.

| # | Ticker | Fund | Top ten weight | Holdings | Net assets | Total return, 1Y |
| --- | --- | --- | --- | --- | --- | --- |
| 1 | BBH | VanEck Biotech ETF | 73.5% | 25 | $525m | +47.2% |
| 2 | PBPH | Portfolio Building Block World Pharma an | 61.9% | 53 | $952m | too new |
| 3 | IBB | iShares Biotechnology ETF | 51.6% | 245 | $11.2bn | +42.0% |
| 4 | PBE | Invesco Biotechnology & Genome ETF | 49.1% | 32 | $442m | +44.2% |
| 5 | IBBQ | Invesco Nasdaq Biotechnology ETF | 48.1% | 254 | $121m | +42.7% |
| 6 | FBT | First Trust NYSE Arca Biotechnology Inde | 38.2% | 30 | $3.1bn | +47.0% |
| 7 | BBP | Virtus Biotech ETF | 19.6% | 67 | $99m | +44.4% |
| 8 | XBI | State Street SPDR S&P Biotech ETF | 18.1% | 165 | $10.6bn | +47.9% |
| 9 | BBC | Virtus Biotech Clinical Trials ETF | 11.8% | 131 | $46m | +45.9% |

### Method

The 9 of 10 ETFs in the biotech theme with a filed book, most concentrated first. Across the funds listed here the weight in the ten largest runs from 11.8% to 73.5%. Concentration is not a fault. It shows how much rides on ten holdings. The list sorts one published number, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.

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### Sources

Links are sources, not endorsements.

A ranking is not a recommendation or an opinion. ETFIQ is an independent publisher, not an adviser. Standards and sources

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Source: ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.
Cite: ETFIQ, The most concentrated biotech ETFs, ranked by the share of the fund held in its ten largest positions, data as of Nov 4, 2026. https://etfiq.com/rankings/themes-concentrated-biotech
Licence: https://etfiq.com/license/ Data ETFIQ computes is free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms.
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