# Biotech ETFs: 10 Ranked by Fee, Nov 2026

> 10 biotech ETFs ranked by fee, as of Nov 4, 2026. PBPH leads at 0.13% a year. IBBQ is second at 0.19% a year. Rebuilt every trading night.

Data as of Nov 4, 2026. Rebuilt every trading night.

As of Nov 4, 2026 . Rebuilt every trading night.

## The cheapest biotech ETFs

See 10 funds ranked by the annual fee the fund charges. Updated Nov 4, 2026. A fee is one fact, not a verdict. Funds on one theme can hold different companies, and the holdings are on the theme page.

| # | Ticker | Fund | Fee | Net assets | Weight in S&P 500 companies | Total return, 1Y |
| --- | --- | --- | --- | --- | --- | --- |
| 1 | PBPH | Portfolio Building Block World Pharma an | 0.13% | $952m | 59.2% | too new |
| 2 | IBBQ | Invesco Nasdaq Biotechnology ETF | 0.19% | $121m | 42.5% | +42.7% |
| 3 | BBP | Virtus Biotech ETF | 0.34% | $99m | 10.5% | +44.4% |
| 4 | BBH | VanEck Biotech ETF | 0.35% | $525m | 64.4% | +47.2% |
| 5 | XBI | State Street SPDR S&P Biotech ETF | 0.35% | $10.6bn | 13.9% | +47.9% |
| 6 | IBB | iShares Biotechnology ETF | 0.44% | $11.2bn | 42.0% | +42.0% |
| 7 | FBT | First Trust NYSE Arca Biotechnology Inde | 0.55% | $3.1bn | 24.8% | +47.0% |
| 8 | TDNA | T. Rowe Price Biotech ETF | 0.55% | $11m | not yet filed | too new |
| 9 | PBE | Invesco Biotechnology & Genome ETF | 0.59% | $442m | 32.3% | +44.2% |
| 10 | BBC | Virtus Biotech Clinical Trials ETF | 0.65% | $46m | 0.0% | +45.9% |

### Method

The 10 of 10 ETFs in the biotech theme that publish an expense ratio, cheapest first. Across the funds listed here the annual fee runs from 0.1% to 0.7%. A fee is the one number a fund controls and the one a holder always pays. The list sorts one published number, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.

### Where to next

### Sources

Links are sources, not endorsements.

A ranking is not a recommendation or an opinion. ETFIQ is an independent publisher, not an adviser. Standards and sources

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Source: ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.
Cite: ETFIQ, The cheapest biotech ETFs, ranked by the annual fee the fund charges, data as of Nov 4, 2026. https://etfiq.com/rankings/themes-cheapest-biotech
Licence: https://etfiq.com/license/ Data ETFIQ computes is free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms.
HTML: https://etfiq.com/rankings/themes-cheapest-biotech