{"url":"https://etfiq.com/rankings/themes-cheapest-biotech","section":"rankings","title":"Biotech ETFs: 10 Ranked by Fee, Nov 2026 | ETFIQ","description":"10 biotech ETFs ranked by fee, as of Nov 4, 2026. PBPH leads at 0.13% a year. IBBQ is second at 0.19% a year. 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PBPH leads at 0.13% a year. IBBQ is second at 0.19% a year. Rebuilt every trading night.","url":"https://etfiq.com/rankings/themes-cheapest-biotech","dateModified":"2026-11-04","creator":{"@id":"https://etfiq.com/#org"},"license":"https://etfiq.com/license/","isAccessibleForFree":true,"creditText":"ETFIQ (etfiq.com)","publisher":{"@id":"https://etfiq.com/#org"},"inLanguage":"en","creativeWorkStatus":"Published","distribution":[{"@type":"DataDownload","encodingFormat":"application/json","contentUrl":"https://etfiq.com/data/thematic.json"}],"variableMeasured":["Weight overlap with the S&P 500","Active share","Holdings","Top ten share of the fund","Total return","Fee for the differing part","Expense ratio"],"keywords":["exchange-traded funds","ETF","Thematic ETFs","fund data","SEC filings"]},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"ETFIQ","item":"https://etfiq.com/"},{"@type":"ListItem","position":2,"name":"Rankings","item":"https://etfiq.com/rankings/"},{"@type":"ListItem","position":3,"name":"The cheapest biotech ETFs","item":"https://etfiq.com/rankings/themes-cheapest-biotech"}]},{"@type":"WebPage","name":"Biotech ETFs: 10 Ranked by Fee, Nov 2026","description":"10 biotech ETFs ranked by fee, as of Nov 4, 2026. PBPH leads at 0.13% a year. IBBQ is second at 0.19% a year. Rebuilt every trading night.","url":"https://etfiq.com/rankings/themes-cheapest-biotech","dateModified":"2026-11-04","isPartOf":{"@type":"WebSite","name":"ETFIQ","url":"https://etfiq.com"},"speakable":{"@type":"SpeakableSpecification","cssSelector":[".lede"]},"publisher":{"@id":"https://etfiq.com/#org"}}],"characters":2855,"truncated":false,"content":"ETFIQ / Rankings / The cheapest biotech ETFs \n \n As of Nov 4, 2026 . Rebuilt every trading night.\n The cheapest biotech ETFs\n See 10 funds ranked by the annual fee the fund charges. Updated Nov 4, 2026. A fee is one fact, not a verdict. Funds on one theme can hold different companies, and the holdings are on the theme page.\n The cheapest biotech ETFs, ranked by the annual fee the fund charges, as of Nov 4, 2026. Source: ETFIQ. # Ticker Fund Fee Net assets Weight in S&P 500 companies Total return, 1Y \n 1 PBPH Portfolio Building Block World Pharma an 0.13% $952m 59.2% too new \n 2 IBBQ Invesco Nasdaq Biotechnology ETF 0.19% $121m 42.5% +42.7% \n 3 BBP Virtus Biotech ETF 0.34% $99m 10.5% +44.4% \n 4 BBH VanEck Biotech ETF 0.35% $525m 64.4% +47.2% \n 5 XBI State Street SPDR S&P Biotech ETF 0.35% $10.6bn 13.9% +47.9% \n 6 IBB iShares Biotechnology ETF 0.44% $11.2bn 42.0% +42.0% \n 7 FBT First Trust NYSE Arca Biotechnology Inde 0.55% $3.1bn 24.8% +47.0% \n 8 TDNA T. Rowe Price Biotech ETF 0.55% $11m not yet filed too new \n 9 PBE Invesco Biotechnology & Genome ETF 0.59% $442m 32.3% +44.2% \n 10 BBC Virtus Biotech Clinical Trials ETF 0.65% $46m 0.0% +45.9% \n \n Method\n The 10 of 10 ETFs in the biotech theme that publish an expense ratio, cheapest first. Across the funds listed here the annual fee runs from 0.1% to 0.7%. A fee is the one number a fund controls and the one a holder always pays. The list sorts one published number, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.\n Where to next\n Every biotech ETF and what it holds The largest biotech ETFs Sources\n Fund holdings from SEC Form N-PORT and from the issuers\u2019 own daily files SEC EDGAR, full-text search of fund filings SEC Form N-PORT, what a fund filed it holds Rule 19a-1, what a distribution notice must say Links are sources, not endorsements.\n A ranking is not a recommendation or an opinion. ETFIQ is an independent publisher, not an adviser. Standards and sources \n Cite this page. ETFIQ, The cheapest biotech ETFs, ranked by the annual fee the fund charges, data as of Nov 4, 2026. https://etfiq.com/rankings/themes-cheapest-biotech Free to use with attribution for data ETFIQ computes; issuer data stays under its owner's terms. The underlying files are at Open data .\n Other forms Plain ETFIQ, The cheapest biotech ETFs, ranked by the annual fee the fund charges, data as of Nov 4, 2026. https://etfiq.com/rankings/themes-cheapest-biotech APA ETFIQ. (Nov 4, 2026). The cheapest biotech ETFs, ranked by the annual fee the fund charges. Retrieved from https://etfiq.com/rankings/themes-cheapest-biotech Markdown [The cheapest biotech ETFs, ranked by the annual fee the fund charges (ETFIQ, Nov 4, 2026)](https://etfiq.com/rankings/themes-cheapest-biotech)","source":"ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.","publisher":{"@id":"https://etfiq.com/#org","name":"ETFIQ","url":"https://etfiq.com"},"license":"https://etfiq.com/license/","license_text":"Data ETFIQ computes is free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms.","citation":"ETFIQ, The cheapest biotech ETFs, ranked by the annual fee the fund charges, data as of Nov 4, 2026. https://etfiq.com/rankings/themes-cheapest-biotech"}