{"url":"https://etfiq.com/rankings/themes-best-year-therapeutics","section":"rankings","title":"The therapeutics ETFs that returned most | ETFIQ","description":"The therapeutics ETFs that returned most, ranked by total return with distributions reinvested, one year, as of Oct 20, 2026.","as_of":"Oct 20, 2026","structured_data":[{"@type":"ItemList","name":"The therapeutics ETFs that returned most","numberOfItems":5,"itemListOrder":"https://schema.org/ItemListOrderDescending","itemListElement":[{"@type":"ListItem","position":1,"name":"CANC","url":"https://etfiq.com/funds/canc"},{"@type":"ListItem","position":2,"name":"IBRN","url":"https://etfiq.com/funds/ibrn"},{"@type":"ListItem","position":3,"name":"PSIL","url":"https://etfiq.com/funds/psil"},{"@type":"ListItem","position":4,"name":"MDEV","url":"https://etfiq.com/funds/mdev"},{"@type":"ListItem","position":5,"name":"IHI","url":"https://etfiq.com/funds/ihi"}]},{"@type":"Dataset","name":"The therapeutics ETFs that returned most","description":"The therapeutics ETFs that returned most, ranked by total return with distributions reinvested, one year, as of Oct 20, 2026.","url":"https://etfiq.com/rankings/themes-best-year-therapeutics","dateModified":"2026-10-20","creator":{"@id":"https://etfiq.com/#org"},"license":"https://etfiq.com/license/","isAccessibleForFree":true,"creditText":"ETFIQ (etfiq.com)","publisher":{"@id":"https://etfiq.com/#org"},"inLanguage":"en","creativeWorkStatus":"Published","distribution":[{"@type":"DataDownload","encodingFormat":"application/json","contentUrl":"https://etfiq.com/data/thematic.json"}],"variableMeasured":["Weight overlap with the S&P 500","Active share","Holdings","Top ten share of the fund","Total return","Fee for the differing part","Expense ratio"],"keywords":["exchange-traded funds","ETF","Thematic ETFs","fund data","SEC filings"]},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"ETFIQ","item":"https://etfiq.com/"},{"@type":"ListItem","position":2,"name":"Rankings","item":"https://etfiq.com/rankings/"},{"@type":"ListItem","position":3,"name":"The therapeutics ETFs that returned most","item":"https://etfiq.com/rankings/themes-best-year-therapeutics"}]},{"@type":"WebPage","name":"The therapeutics ETFs that returned most","description":"The therapeutics ETFs that returned most, ranked by total return with distributions reinvested, one year, as of Oct 20, 2026.","url":"https://etfiq.com/rankings/themes-best-year-therapeutics","dateModified":"2026-10-20","isPartOf":{"@type":"WebSite","name":"ETFIQ","url":"https://etfiq.com"},"speakable":{"@type":"SpeakableSpecification","cssSelector":[".lede"]},"publisher":{"@id":"https://etfiq.com/#org"}}],"characters":2921,"truncated":false,"content":"ETFIQ / Rankings / The therapeutics ETFs that returned most \n \n As of Oct 20, 2026 . Rebuilt every trading night.\n The therapeutics ETFs that returned most\n See 5 funds ranked by total return with distributions reinvested, one year. Updated Oct 20, 2026. Funds on one theme can hold different companies, so the gap from top to bottom of this list reflects what they own, not the theme.\n The therapeutics ETFs that returned most, ranked by total return with distributions reinvested, as of Oct 20, 2026. Source: ETFIQ. # Ticker Fund Total return, 1Y vs its benchmark 1Y Weight in S&P 500 companies Fee \n 1 CANC Tema Oncology ETF +36.5% not measured 21.9% 0.75% \n 2 IBRN iShares Neuroscience and Healthcare ETF +9.3% not measured 5.3% 0.47% \n 3 PSIL AdvisorShares Psychedelics ETF +7.0% not measured 7.8% 1.00% \n 4 MDEV First Trust Indxx Medical Devices ETF +4.4% not measured 47.4% 0.70% \n 5 IHI iShares U.S. Medical Devices ETF \u221210.1% not measured 88.5% 0.37% \n \n Method\n The 5 of 5 ETFs in the therapeutics and medical devices theme with a full year of trading, highest first, each over the same year to Oct 20, 2026 with distributions reinvested. Across the funds listed here the one year total return runs from -10.1% to 36.5%. A year says what happened, not what happens next. The list sorts one published figure, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.\n Where to next\n Every therapeutics and medical devices ETF and what it holds The largest therapeutics and medical devices ETFs Where these figures came from\n Fund holdings from SEC Form N-PORT and from the issuers own daily files SEC EDGAR, full-text search of fund filings SEC Form N-PORT, what a fund filed it holds Rule 19a-1, what a distribution notice must say ETFIQ links to the documents behind every figure; a link is not an endorsement.\n A ranking is not a recommendation or an opinion. ETFIQ is an independent publisher, not an adviser. Standards and sources \n Cite this page. ETFIQ, The therapeutics ETFs that returned most, ranked by total return with distributions reinvested, data as of Oct 20, 2026. https://etfiq.com/rankings/themes-best-year-therapeutics Free to use with attribution for figures ETFIQ computes; issuer data stays under its owner's terms. The underlying files are at Open data .\n Other forms Plain ETFIQ, The therapeutics ETFs that returned most, ranked by total return with distributions reinvested, data as of Oct 20, 2026. https://etfiq.com/rankings/themes-best-year-therapeutics APA ETFIQ. (Oct 20, 2026). The therapeutics ETFs that returned most, ranked by total return with distributions reinvested. Retrieved from https://etfiq.com/rankings/themes-best-year-therapeutics Markdown [The therapeutics ETFs that returned most, ranked by total return with distributions reinvested (ETFIQ, Oct 20, 2026)](https://etfiq.com/rankings/themes-best-year-therapeutics)","source":"ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.","publisher":{"@id":"https://etfiq.com/#org","name":"ETFIQ","url":"https://etfiq.com"},"license":"https://etfiq.com/license/","license_text":"Figures ETFIQ computes are free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms.","citation":"ETFIQ, The therapeutics ETFs that returned most, ranked by total return with distributions reinvested, data as of Oct 20, 2026. https://etfiq.com/rankings/themes-best-year-therapeutics"}