# The healthcare innovation ETFs that returned most

> The healthcare innovation ETFs that returned most, ranked by total return with distributions reinvested, one year, as of Oct 20, 2026.

Data as of Oct 20, 2026. Rebuilt every trading night.

As of Oct 20, 2026 . Rebuilt every trading night.

## The healthcare innovation ETFs that returned most

See 8 funds ranked by total return with distributions reinvested, one year. Updated Oct 20, 2026. Funds on one theme can hold different companies, so the gap from top to bottom of this list reflects what they own, not the theme.

| # | Ticker | Fund | Total return, 1Y | vs its benchmark 1Y | Weight in S&P 500 companies | Fee |
| --- | --- | --- | --- | --- | --- | --- |
| 1 | WDNA | WisdomTree BioRevolution Fund | +36.0% | not measured | 25.9% | 0.45% |
| 2 | EKG | First Trust Nasdaq Lux Digital Health So | +31.2% | not measured | 41.4% | 0.65% |
| 3 | BMED | iShares Health Innovation Active ETF | +25.4% | not measured | 58.4% | 0.55% |
| 4 | HELX | Franklin Genomic Advancements ETF | +25.1% | not measured | 14.9% | 0.50% |
| 5 | LGHT | Langar Global HealthTech ETF | +10.1% | not measured | 57.9% | 0.85% |
| 6 | OZEM | Roundhill GLP-1 & Weight Loss ETF | +8.8% | not measured | 29.3% | 0.59% |
| 7 | THNR | Amplify Weight Loss Drug & Treatment ETF | +7.8% | not measured | 44.8% | 0.59% |
| 8 | HEAL | Global X HealthTech ETF | −6.1% | not measured | 28.8% | 0.50% |

### Method

The 8 of 8 ETFs in the healthcare innovation and glp-1 theme with a full year of trading, highest first, each over the same year to Oct 20, 2026 with distributions reinvested. Across the funds listed here the one year total return runs from -6.1% to 36.0%. A year says what happened, not what happens next. The list sorts one published figure, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.

### Where to next

### Where these figures came from

ETFIQ links to the documents behind every figure; a link is not an endorsement.

A ranking is not a recommendation or an opinion. ETFIQ is an independent publisher, not an adviser. Standards and sources

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Source: ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.
Cite: ETFIQ, The healthcare innovation ETFs that returned most, ranked by total return with distributions reinvested, data as of Oct 20, 2026. https://etfiq.com/rankings/themes-best-year-health-innovation
Licence: https://etfiq.com/license/ Figures ETFIQ computes are free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms.
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