{"url":"https://etfiq.com/rankings/themes-best-year-health-innovation","section":"rankings","title":"The healthcare innovation ETFs that returned most | ETFIQ","description":"The healthcare innovation ETFs that returned most, ranked by total return with distributions reinvested, one year, as of Oct 20, 2026.","as_of":"Oct 20, 2026","structured_data":[{"@type":"ItemList","name":"The healthcare innovation ETFs that returned most","numberOfItems":8,"itemListOrder":"https://schema.org/ItemListOrderDescending","itemListElement":[{"@type":"ListItem","position":1,"name":"WDNA","url":"https://etfiq.com/funds/wdna"},{"@type":"ListItem","position":2,"name":"EKG","url":"https://etfiq.com/funds/ekg"},{"@type":"ListItem","position":3,"name":"BMED","url":"https://etfiq.com/funds/bmed"},{"@type":"ListItem","position":4,"name":"HELX","url":"https://etfiq.com/funds/helx"},{"@type":"ListItem","position":5,"name":"LGHT","url":"https://etfiq.com/funds/lght"},{"@type":"ListItem","position":6,"name":"OZEM","url":"https://etfiq.com/funds/ozem"},{"@type":"ListItem","position":7,"name":"THNR","url":"https://etfiq.com/funds/thnr"},{"@type":"ListItem","position":8,"name":"HEAL","url":"https://etfiq.com/funds/heal"}]},{"@type":"Dataset","name":"The healthcare innovation ETFs that returned most","description":"The healthcare innovation ETFs that returned most, ranked by total return with distributions reinvested, one year, as of Oct 20, 2026.","url":"https://etfiq.com/rankings/themes-best-year-health-innovation","dateModified":"2026-10-20","creator":{"@id":"https://etfiq.com/#org"},"license":"https://etfiq.com/license/","isAccessibleForFree":true,"creditText":"ETFIQ (etfiq.com)","publisher":{"@id":"https://etfiq.com/#org"},"inLanguage":"en","creativeWorkStatus":"Published","distribution":[{"@type":"DataDownload","encodingFormat":"application/json","contentUrl":"https://etfiq.com/data/thematic.json"}],"variableMeasured":["Weight overlap with the S&P 500","Active share","Holdings","Top ten share of the fund","Total return","Fee for the differing part","Expense ratio"],"keywords":["exchange-traded funds","ETF","Thematic ETFs","fund data","SEC filings"]},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"ETFIQ","item":"https://etfiq.com/"},{"@type":"ListItem","position":2,"name":"Rankings","item":"https://etfiq.com/rankings/"},{"@type":"ListItem","position":3,"name":"The healthcare innovation ETFs that return...","item":"https://etfiq.com/rankings/themes-best-year-health-innovation"}]},{"@type":"WebPage","name":"The healthcare innovation ETFs that returned most","description":"The healthcare innovation ETFs that returned most, ranked by total return with distributions reinvested, one year, as of Oct 20, 2026.","url":"https://etfiq.com/rankings/themes-best-year-health-innovation","dateModified":"2026-10-20","isPartOf":{"@type":"WebSite","name":"ETFIQ","url":"https://etfiq.com"},"speakable":{"@type":"SpeakableSpecification","cssSelector":[".lede"]},"publisher":{"@id":"https://etfiq.com/#org"}}],"characters":3211,"truncated":false,"content":"ETFIQ / Rankings / The healthcare innovation ETFs that return... \n \n As of Oct 20, 2026 . Rebuilt every trading night.\n The healthcare innovation ETFs that returned most\n See 8 funds ranked by total return with distributions reinvested, one year. Updated Oct 20, 2026. Funds on one theme can hold different companies, so the gap from top to bottom of this list reflects what they own, not the theme.\n The healthcare innovation ETFs that returned most, ranked by total return with distributions reinvested, as of Oct 20, 2026. Source: ETFIQ. # Ticker Fund Total return, 1Y vs its benchmark 1Y Weight in S&P 500 companies Fee \n 1 WDNA WisdomTree BioRevolution Fund +36.0% not measured 25.9% 0.45% \n 2 EKG First Trust Nasdaq Lux Digital Health So +31.2% not measured 41.4% 0.65% \n 3 BMED iShares Health Innovation Active ETF +25.4% not measured 58.4% 0.55% \n 4 HELX Franklin Genomic Advancements ETF +25.1% not measured 14.9% 0.50% \n 5 LGHT Langar Global HealthTech ETF +10.1% not measured 57.9% 0.85% \n 6 OZEM Roundhill GLP-1 & Weight Loss ETF +8.8% not measured 29.3% 0.59% \n 7 THNR Amplify Weight Loss Drug & Treatment ETF +7.8% not measured 44.8% 0.59% \n 8 HEAL Global X HealthTech ETF \u22126.1% not measured 28.8% 0.50% \n \n Method\n The 8 of 8 ETFs in the healthcare innovation and glp-1 theme with a full year of trading, highest first, each over the same year to Oct 20, 2026 with distributions reinvested. Across the funds listed here the one year total return runs from -6.1% to 36.0%. A year says what happened, not what happens next. The list sorts one published figure, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.\n Where to next\n Every healthcare innovation ETF and what it holds The largest healthcare innovation ETFs Where these figures came from\n Fund holdings from SEC Form N-PORT and from the issuers own daily files SEC EDGAR, full-text search of fund filings SEC Form N-PORT, what a fund filed it holds Rule 19a-1, what a distribution notice must say ETFIQ links to the documents behind every figure; a link is not an endorsement.\n A ranking is not a recommendation or an opinion. ETFIQ is an independent publisher, not an adviser. Standards and sources \n Cite this page. ETFIQ, The healthcare innovation ETFs that returned most, ranked by total return with distributions reinvested, data as of Oct 20, 2026. https://etfiq.com/rankings/themes-best-year-health-innovation Free to use with attribution for figures ETFIQ computes; issuer data stays under its owner's terms. The underlying files are at Open data .\n Other forms Plain ETFIQ, The healthcare innovation ETFs that returned most, ranked by total return with distributions reinvested, data as of Oct 20, 2026. https://etfiq.com/rankings/themes-best-year-health-innovation APA ETFIQ. (Oct 20, 2026). The healthcare innovation ETFs that returned most, ranked by total return with distributions reinvested. Retrieved from https://etfiq.com/rankings/themes-best-year-health-innovation Markdown [The healthcare innovation ETFs that returned most, ranked by total return with distributions reinvested (ETFIQ, Oct 20, 2026)](https://etfiq.com/rankings/themes-best-year-health-innovation)","source":"ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.","publisher":{"@id":"https://etfiq.com/#org","name":"ETFIQ","url":"https://etfiq.com"},"license":"https://etfiq.com/license/","license_text":"Figures ETFIQ computes are free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms.","citation":"ETFIQ, The healthcare innovation ETFs that returned most, ranked by total return with distributions reinvested, data as of Oct 20, 2026. https://etfiq.com/rankings/themes-best-year-health-innovation"}