# Biotech ETFs: 8 Ranked by 1-Year Return, Nov 2026

> 8 biotech ETFs ranked by total return over one year, as of Nov 4, 2026. XBI leads at +47.9% over one year. BBH is second at +47.2% over one year.

Data as of Nov 4, 2026. Rebuilt every trading night.

As of Nov 4, 2026 . Rebuilt every trading night.

## The biotech ETFs that returned most

See 8 funds ranked by total return with distributions reinvested, one year. Updated Nov 4, 2026. Funds on one theme can hold different companies, so the gap from top to bottom reflects what they own, not the theme.

| # | Ticker | Fund | Total return, 1Y | vs its benchmark 1Y | Weight in S&P 500 companies | Fee |
| --- | --- | --- | --- | --- | --- | --- |
| 1 | XBI | State Street SPDR S&P Biotech ETF | +47.9% | not measured | 13.9% | 0.35% |
| 2 | BBH | VanEck Biotech ETF | +47.2% | not measured | 64.4% | 0.35% |
| 3 | FBT | First Trust NYSE Arca Biotechnology Inde | +47.0% | not measured | 24.8% | 0.55% |
| 4 | BBC | Virtus Biotech Clinical Trials ETF | +45.9% | not measured | 0.0% | 0.65% |
| 5 | BBP | Virtus Biotech ETF | +44.4% | not measured | 10.5% | 0.34% |
| 6 | PBE | Invesco Biotechnology & Genome ETF | +44.2% | not measured | 32.3% | 0.59% |
| 7 | IBBQ | Invesco Nasdaq Biotechnology ETF | +42.7% | not measured | 42.5% | 0.19% |
| 8 | IBB | iShares Biotechnology ETF | +42.0% | not measured | 42.0% | 0.44% |

### Method

The 8 of 10 ETFs in the biotech theme with a full year of trading, highest first, each over the same year to Nov 4, 2026 with distributions reinvested. Across the funds listed here the one year total return runs from 42.0% to 47.9%. A year says what happened, not what happens next. The list sorts one published number, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.

### Where to next

### Sources

Links are sources, not endorsements.

A ranking is not a recommendation or an opinion. ETFIQ is an independent publisher, not an adviser. Standards and sources

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Source: ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.
Cite: ETFIQ, The biotech ETFs that returned most, ranked by total return with distributions reinvested, data as of Nov 4, 2026. https://etfiq.com/rankings/themes-best-year-biotech
Licence: https://etfiq.com/license/ Data ETFIQ computes is free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms.
HTML: https://etfiq.com/rankings/themes-best-year-biotech