{"url":"https://etfiq.com/rankings/themes-best-year-biotech","section":"rankings","title":"Biotech ETFs: 8 Ranked by 1-Year Return, Nov 2026 | ETFIQ","description":"8 biotech ETFs ranked by total return over one year, as of Nov 4, 2026. XBI leads at +47.9% over one year. BBH is second at +47.2% over one year.","as_of":"Nov 4, 2026","structured_data":[{"@type":"ItemList","name":"The biotech ETFs that returned most","numberOfItems":8,"itemListOrder":"https://schema.org/ItemListOrderDescending","itemListElement":[{"@type":"ListItem","position":1,"name":"XBI","url":"https://etfiq.com/funds/xbi"},{"@type":"ListItem","position":2,"name":"BBH","url":"https://etfiq.com/funds/bbh"},{"@type":"ListItem","position":3,"name":"FBT","url":"https://etfiq.com/funds/fbt"},{"@type":"ListItem","position":4,"name":"BBC","url":"https://etfiq.com/funds/bbc"},{"@type":"ListItem","position":5,"name":"BBP","url":"https://etfiq.com/funds/bbp"},{"@type":"ListItem","position":6,"name":"PBE","url":"https://etfiq.com/funds/pbe"},{"@type":"ListItem","position":7,"name":"IBBQ","url":"https://etfiq.com/funds/ibbq"},{"@type":"ListItem","position":8,"name":"IBB","url":"https://etfiq.com/funds/ibb"}]},{"@type":"Dataset","name":"The biotech ETFs that returned most","description":"8 biotech ETFs ranked by total return over one year, as of Nov 4, 2026. XBI leads at +47.9% over one year. BBH is second at +47.2% over one year.","url":"https://etfiq.com/rankings/themes-best-year-biotech","dateModified":"2026-11-04","creator":{"@id":"https://etfiq.com/#org"},"license":"https://etfiq.com/license/","isAccessibleForFree":true,"creditText":"ETFIQ (etfiq.com)","publisher":{"@id":"https://etfiq.com/#org"},"inLanguage":"en","creativeWorkStatus":"Published","distribution":[{"@type":"DataDownload","encodingFormat":"application/json","contentUrl":"https://etfiq.com/data/thematic.json"}],"variableMeasured":["Weight overlap with the S&P 500","Active share","Holdings","Top ten share of the fund","Total return","Fee for the differing part","Expense ratio"],"keywords":["exchange-traded funds","ETF","Thematic ETFs","fund data","SEC filings"]},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"ETFIQ","item":"https://etfiq.com/"},{"@type":"ListItem","position":2,"name":"Rankings","item":"https://etfiq.com/rankings/"},{"@type":"ListItem","position":3,"name":"The biotech ETFs that returned most","item":"https://etfiq.com/rankings/themes-best-year-biotech"}]},{"@type":"WebPage","name":"Biotech ETFs: 8 Ranked by 1-Year Return, Nov 2026","description":"8 biotech ETFs ranked by total return over one year, as of Nov 4, 2026. XBI leads at +47.9% over one year. BBH is second at +47.2% over one year.","url":"https://etfiq.com/rankings/themes-best-year-biotech","dateModified":"2026-11-04","isPartOf":{"@type":"WebSite","name":"ETFIQ","url":"https://etfiq.com"},"speakable":{"@type":"SpeakableSpecification","cssSelector":[".lede"]},"publisher":{"@id":"https://etfiq.com/#org"}}],"characters":2971,"truncated":false,"content":"ETFIQ / Rankings / The biotech ETFs that returned most \n \n As of Nov 4, 2026 . Rebuilt every trading night.\n The biotech ETFs that returned most\n See 8 funds ranked by total return with distributions reinvested, one year. Updated Nov 4, 2026. Funds on one theme can hold different companies, so the gap from top to bottom reflects what they own, not the theme.\n The biotech ETFs that returned most, ranked by total return with distributions reinvested, as of Nov 4, 2026. Source: ETFIQ. # Ticker Fund Total return, 1Y vs its benchmark 1Y Weight in S&P 500 companies Fee \n 1 XBI State Street SPDR S&P Biotech ETF +47.9% not measured 13.9% 0.35% \n 2 BBH VanEck Biotech ETF +47.2% not measured 64.4% 0.35% \n 3 FBT First Trust NYSE Arca Biotechnology Inde +47.0% not measured 24.8% 0.55% \n 4 BBC Virtus Biotech Clinical Trials ETF +45.9% not measured 0.0% 0.65% \n 5 BBP Virtus Biotech ETF +44.4% not measured 10.5% 0.34% \n 6 PBE Invesco Biotechnology & Genome ETF +44.2% not measured 32.3% 0.59% \n 7 IBBQ Invesco Nasdaq Biotechnology ETF +42.7% not measured 42.5% 0.19% \n 8 IBB iShares Biotechnology ETF +42.0% not measured 42.0% 0.44% \n \n Method\n The 8 of 10 ETFs in the biotech theme with a full year of trading, highest first, each over the same year to Nov 4, 2026 with distributions reinvested. Across the funds listed here the one year total return runs from 42.0% to 47.9%. A year says what happened, not what happens next. The list sorts one published number, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.\n Where to next\n Every biotech ETF and what it holds The largest biotech ETFs Sources\n Fund holdings from SEC Form N-PORT and from the issuers\u2019 own daily files SEC EDGAR, full-text search of fund filings SEC Form N-PORT, what a fund filed it holds Rule 19a-1, what a distribution notice must say Links are sources, not endorsements.\n A ranking is not a recommendation or an opinion. ETFIQ is an independent publisher, not an adviser. Standards and sources \n Cite this page. ETFIQ, The biotech ETFs that returned most, ranked by total return with distributions reinvested, data as of Nov 4, 2026. https://etfiq.com/rankings/themes-best-year-biotech Free to use with attribution for data ETFIQ computes; issuer data stays under its owner's terms. The underlying files are at Open data .\n Other forms Plain ETFIQ, The biotech ETFs that returned most, ranked by total return with distributions reinvested, data as of Nov 4, 2026. https://etfiq.com/rankings/themes-best-year-biotech APA ETFIQ. (Nov 4, 2026). The biotech ETFs that returned most, ranked by total return with distributions reinvested. Retrieved from https://etfiq.com/rankings/themes-best-year-biotech Markdown [The biotech ETFs that returned most, ranked by total return with distributions reinvested (ETFIQ, Nov 4, 2026)](https://etfiq.com/rankings/themes-best-year-biotech)","source":"ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.","publisher":{"@id":"https://etfiq.com/#org","name":"ETFIQ","url":"https://etfiq.com"},"license":"https://etfiq.com/license/","license_text":"Data ETFIQ computes is free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms.","citation":"ETFIQ, The biotech ETFs that returned most, ranked by total return with distributions reinvested, data as of Nov 4, 2026. https://etfiq.com/rankings/themes-best-year-biotech"}