# ETFs That Hold Vertex Pharmaceuticals Inc (VRTX)

> 322 thematic and core ETFs hold Vertex Pharmaceuticals Inc (VRTX). BBH holds the most, at 7.98% of the fund on Nov 3, 2026.

Data as of Nov 5, 2026. Rebuilt every trading night.

## ETFs that hold Vertex Pharmaceuticals Inc

322 thematic and core ETFs hold Vertex Pharmaceuticals Inc , by holdings dated Jun 30, 2026 to Nov 4, 2026 . BBH holds the most, at 7.98% of the fund on Nov 3, 2026 . The next largest are IBBQ (7.65%) and IBB (7.55%).

23 income and other funds on it are listed below.

### Thematic and core funds that hold it

| Fund | Name | Share of the fund | Holdings filed | Asset |
| --- | --- | --- | --- | --- |
| BBH | VanEck Biotech ETF | 7.98% | Nov 3, 2026 | Equity |
| IBBQ | Invesco Nasdaq Biotechnology ETF | 7.65% | Nov 3, 2026 | Equity |
| IBB | iShares Biotechnology ETF | 7.55% | Nov 3, 2026 | Equity |
| GNMX | Corgi Genomics & Precision Medicine ETF | 6.04% | Nov 4, 2026 | Equity |
| LSGR | Natixis Loomis Sayles Focused Growth ETF | 4.78% | Jun 30, 2026 | Equity |
| HLTH | Tema Healthcare AI ETF | 4.70% | Nov 3, 2026 | Equity |
| PBE | Invesco Biotechnology & Genome ETF | 4.62% | Nov 3, 2026 | Equity |
| GDOC | Goldman Sachs Future Health Care Equity ETF | 4.20% | Aug 31, 2026 | Equity |
| GNOM | Global X Genomics & Biotechnology ETF | 3.70% | Aug 31, 2026 | Equity |
| FBT | First Trust NYSE Arca Biotechnology Index Fund | 3.34% | Nov 3, 2026 | Equity |
| FTXH | First Trust Nasdaq Pharmaceuticals ETF | 3.29% | Nov 3, 2026 | Equity |
| IDNA | iShares Genomics Immunology and Healthcare ETF | 3.29% | Nov 3, 2026 | Equity |
| BMED | iShares Health Innovation Active ETF | 3.24% | Nov 3, 2026 | Equity |
| QFRD | Pacer S&P 500 Quality FCF R&D Leaders ETF | 2.98% | Jul 31, 2026 | Equity |
| SXQG | ETC 6 Meridian Quality Growth ETF | 2.92% | Aug 31, 2026 | Equity |
| HRTS | Tema Heart & Health ETF | 2.85% | Nov 3, 2026 | Equity |
| PBPH | Portfolio Building Block World Pharma and Biotech Index ETF | 2.82% | Jul 31, 2026 | Equity |
| HELX | Franklin Genomic Advancements ETF | 2.75% | Jun 30, 2026 | Equity |
| TECB | iShares U.S. Tech Breakthrough Multisector ETF | 2.69% | Nov 3, 2026 | Equity |
| KONG | Formidable Fortress ETF | 2.66% | Jun 30, 2026 | Equity |
| QNXT | iShares Nasdaq-100 ex Top 30 ETF | 2.58% | Nov 3, 2026 | Equity |
| EXEQ | Wedbush ReturnOnLeadership U.S. Large-Cap ETF | 2.49% | Jul 31, 2026 | Equity |
| CGGG | Capital Group U.S. Large Growth ETF | 2.29% | Aug 31, 2026 | Equity |
| LRGE | ClearBridge Large Cap Growth Select ETF | 2.28% | Jun 30, 2026 | Equity |
| TRUH | VanEck Healthcare TruSector ETF | 2.21% | Jun 30, 2026 | Equity |
| QQEW | First Trust Nasdaq-100 Select Equal Weight ETF | 2.09% | Nov 3, 2026 | Equity |
| PVAL | Putnam Focused Large Cap Value ETF | 2.07% | Aug 31, 2026 | Equity |
| ASLV | Allspring Special Large Value ETF | 2.05% | Jul 31, 2026 | Equity |
| FTCS | First Trust Capital Strength ETF | 2.04% | Nov 3, 2026 | Equity |
| CGGR | Capital Group Growth ETF | 2.03% | Aug 31, 2026 | Equity |
| XLV | State Street Health Care Select Sector SPDR ETF | 2.02% | Nov 3, 2026 | Equity |
| NBFR | Innovator Nasdaq-100 Managed 10 Buffer ETF | 1.97% | Jul 31, 2026 | Equity |
| IYH | iShares U.S. Healthcare ETF | 1.97% | Nov 3, 2026 | Equity |
| DRUP | GraniteShares Nasdaq Select Disruptors ETF | 1.94% | Jun 30, 2026 | Equity |
| HTEC | ROBO Global Healthcare Technology and Innovation ETF | 1.91% | Jul 31, 2026 | Equity |
| CGUS | Capital Group Core Equity ETF | 1.90% | Aug 31, 2026 | Equity |
| VHT | Vanguard Health Care ETF | 1.85% | Sep 30, 2026 | Equity |
| QQXT | First Trust Nasdaq-100 Ex-Technology Sector Index Fund | 1.82% | Nov 3, 2026 | Equity |
| TOLL | Tema Durable Quality ETF | 1.80% | Nov 3, 2026 | Equity |
| FHLC | Fidelity MSCI Health Care Index ETF | 1.75% | Jul 31, 2026 | Equity |
| FFND | One Global ETF | 1.73% | Aug 31, 2026 | Equity |
| QQQG | Pacer Nasdaq 100 Top 50 Cash Cows Growth Leaders ETF | 1.64% | Jul 31, 2026 | Equity |
| PJFG | PGIM Jennison Focused Growth ETF | 1.62% | Aug 31, 2026 | Equity |
| JDOC | JPMorgan Healthcare Leaders ETF | 1.62% | Nov 3, 2026 | Equity |
| RND | First Trust Bloomberg R&D Leaders ETF | 1.62% | Nov 3, 2026 | Equity |
| CGGO | Capital Group Global Growth Equity ETF | 1.61% | Aug 31, 2026 | Equity |
| REGS | Columbia Large Cap Growth ETF | 1.58% | Jun 30, 2026 | Equity |
| SDG | iShares MSCI Global Sustainable Development Goals ETF | 1.58% | Nov 3, 2026 | Equity |
| RSPH | Invesco S&P 500 Equal Weight Health Care ETF | 1.54% | Nov 3, 2026 | Equity |
| IXJ | iShares Global Healthcare ETF | 1.52% | Nov 3, 2026 | Equity |
| NULG | Nuveen ESG Large-Cap Growth ETF | 1.50% | Jul 31, 2026 | Equity |
| XBI | State Street SPDR S&P Biotech ETF | 1.49% | Nov 3, 2026 | Equity |
| BBP | Virtus Biotech ETF | 1.48% | Jul 31, 2026 | Equity |
| CGVV | Capital Group U.S. Large Value ETF | 1.45% | Aug 31, 2026 | Equity |
| PINK | Simplify Health Care ETF | 1.45% | Jun 30, 2026 | Equity |
| ESMV | iShares ESG Optimized MSCI USA Min Vol Factor ETF | 1.43% | Nov 3, 2026 | Equity |
| USMV | iShares MSCI USA Min Vol Factor ETF | 1.37% | Nov 3, 2026 | Equity |
| SEIQ | SEI Enhanced U.S. Large Cap Quality Factor ETF | 1.36% | Jun 30, 2026 | Equity |
| WDNA | WisdomTree BioRevolution Fund | 1.34% | Jun 30, 2026 | Equity |
| RILA | Indexperts Gorilla Aggressive Growth ETF | 1.26% | Jul 31, 2026 | Equity |
| MEDI | Harbor Health Care ETF | 1.22% | Jul 31, 2026 | Equity |
| CGBL | Capital Group Core Balanced ETF | 1.20% | Jun 30, 2026 | Equity |
| BGRO | iShares Large Cap Growth Active ETF | 1.20% | Nov 3, 2026 | Equity |
| RFFC | ALPS Active Equity Opportunity ETF | 1.15% | Aug 31, 2026 | Equity |
| AGRW | Allspring LT Large Growth ETF | 1.11% | Jul 31, 2026 | Equity |
| QQQE | Direxion NASDAQ-100 Equal Weighted Index ETF | 1.08% | Jul 31, 2026 | Equity |
| LGRO | Level Four Large Cap Growth Active ETF | 1.08% | Aug 31, 2026 | Equity |
| SQS | Sapient Quality Select ETF | 1.07% | Jul 31, 2026 | Equity |
| LST | Leuthold Select Industries ETF | 1.03% | Jun 30, 2026 | Equity |
| QEW | Invesco QQQ Equal Weight ETF | 1.02% | Nov 3, 2026 | Equity |
| XIGV | Defiance US 100 Tech Ex Software ETF | 0.98% | Nov 4, 2026 | Equity |
| FXH | First Trust Health Care AlphaDEX Fund | 0.91% | Nov 3, 2026 | Equity |
| LRGC | AB US Large Cap Strategic Equities ETF | 0.91% | Aug 31, 2026 | Equity |
| COWG | Pacer US Large Cap Cash Cows Growth Leaders ETF | 0.81% | Jul 31, 2026 | Equity |
| LVDS | JPMorgan Fundamental Data Science Large Value ETF | 0.80% | Nov 3, 2026 | Equity |
| GUSE | Goldman Sachs Enhanced U.S. Equity ETF | 0.79% | Aug 31, 2026 | Equity |
| SGLC | SGI U.S. Large Cap Core ETF | 0.79% | Aug 31, 2026 | Equity |
| CGDV | Capital Group Dividend Value ETF | 0.79% | Aug 31, 2026 | Equity |
| XOEF | iShares S&P 500 ex S&P 100 ETF | 0.77% | Nov 3, 2026 | Equity |
| JOET | Virtus Terranova U.S. Quality Momentum ETF | 0.77% | Jul 31, 2026 | Equity |
| QUS | State Street SPDR MSCI USA StrategicFactors ETF | 0.76% | Nov 3, 2026 | Equity |
| MODL | VictoryShares WestEnd U.S. Sector ETF | 0.76% | Jun 30, 2026 | Equity |
| NDOW | Anydrus Advantage ETF | 0.74% | Jun 30, 2026 | Equity |
| AVIE | Avantis Inflation Focused Equity ETF | 0.73% | Nov 2, 2026 | Equity |
| OMFL | Invesco Russell 1000 Dynamic Multifactor ETF | 0.71% | Nov 3, 2026 | Equity |
| LRND | NYLIM U.S. Large Cap R&D Leaders ETF | 0.69% | Jul 31, 2026 | Equity |
| TNXT | T. Rowe Price Innovation Leaders ETF | 0.67% | Jun 30, 2026 | Equity |
| XT | iShares Future Exponential Technologies ETF | 0.66% | Nov 3, 2026 | Equity |
| QIDX | Indexperts Quality Earnings Focused ETF | 0.65% | Jul 31, 2026 | Equity |
| QGRW | WisdomTree U.S. Quality Growth Fund | 0.63% | Jun 30, 2026 | Equity |
| CRTC | Xtrackers US National Critical Technologies ETF | 0.63% | Aug 31, 2026 | Equity |
| QQQH | NEOS Nasdaq-100 Hedged Equity Income ETF | 0.62% | Nov 3, 2026 | Equity |
| TUG | STF Tactical Growth ETF | 0.62% | Jun 30, 2026 | Equity |
| QNDX | STATE STREET SPDR NASDAQ 100 ETF | 0.61% | Nov 3, 2026 | Equity |
| MGK | Vanguard Morningstar Mega Cap Growth ETF | 0.61% | Sep 30, 2026 | Equity |
| QQQ | Invesco QQQ Trust, Series 1 | 0.61% | Nov 3, 2026 | Equity |
| QQQM | Invesco NASDAQ 100 ETF | 0.61% | Nov 3, 2026 | Equity |
| BDYN | iShares Dynamic Equity Active ETF | 0.60% | Nov 3, 2026 | Equity |
| BAMG | Brookstone Growth Stock ETF | 0.59% | Aug 31, 2026 | Equity |
| SEPQ | STF Tactical Growth & Income ETF | 0.58% | Jun 30, 2026 | Equity |
| CAPE | DoubleLine Shiller CAPE U.S. Equities ETF | 0.58% | Jun 30, 2026 | Equity |
| VUSG | Vanguard Wellington U.S. Growth Active ETF | 0.57% | Sep 30, 2026 | Equity |
| ACLC | American Century Large Cap Equity ETF | 0.57% | Aug 31, 2026 | Equity |
| FTC | First Trust Large Cap Growth AlphaDEX Fund | 0.56% | Nov 3, 2026 | Equity |
| USXF | iShares ESG Advanced MSCI USA ETF | 0.56% | Nov 3, 2026 | Equity |
| PTNQ | Pacer Trendpilot 100 ETF | 0.56% | Jul 31, 2026 | Equity |
| ACWV | iShares MSCI Global Min Vol Factor ETF | 0.55% | Nov 3, 2026 | Equity |
| QQMG | Invesco ESG NASDAQ 100 ETF | 0.55% | Nov 3, 2026 | Equity |
| QQWZ | Pacer Cash COWZ 100-Nasdaq 100 Rotator ETF | 0.54% | Jul 31, 2026 | Equity |
| SCHG | Schwab U.S. Large-Cap Growth ETF | 0.53% | Aug 31, 2026 | Equity |
| CDEI | | 0.53% | Jun 30, 2026 | Equity |
| XCHG | AB US Equity ETF | 0.53% | Aug 31, 2026 | Equity |
| DFUV | Dimensional US Marketwide Value ETF | 0.53% | Jul 31, 2026 | Equity |
| GINN | Goldman Sachs Innovate Equity ETF | 0.52% | Aug 31, 2026 | Equity |
| QSIX | Pacer Metaurus Nasdaq 100 Dividend Multiplier 600 ETF | 0.51% | Jul 31, 2026 | Equity |
| FWD | AB Disruptors ETF | 0.50% | Aug 31, 2026 | Equity |
| IWX | iShares Russell Top 200 Value ETF | 0.49% | Nov 3, 2026 | Equity |
| HBTA | HORIZON EXPEDITION PLUS ETF | 0.47% | Aug 31, 2026 | Equity |
| SFY | SoFi Select 500 ETF | 0.47% | Aug 31, 2026 | Equity |
| QUAL | iShares MSCI USA Quality Factor ETF | 0.46% | Nov 3, 2026 | Equity |
| SHE | State Street SPDR MSCI USA Gender Diversity ETF | 0.46% | Nov 3, 2026 | Equity |
| QQA | Invesco QQQ Income Advantage ETF | 0.46% | Nov 3, 2026 | Equity |
| VOOV | Vanguard S&P 500 Value ETF | 0.46% | Sep 30, 2026 | Equity |
| CGGE | Capital Group Global Equity ETF | 0.45% | Aug 31, 2026 | Equity |
| TMFC | Motley Fool 100 Index ETF | 0.45% | Aug 31, 2026 | Equity |
| SPYV | State Street SPDR Portfolio S&P 500 Value ETF | 0.44% | Nov 3, 2026 | Equity |
| QWLD | State Street SPDR MSCI World StrategicFactors ETF | 0.44% | Nov 3, 2026 | Equity |
| IVE | iShares S&P 500 Value ETF | 0.44% | Nov 3, 2026 | Equity |
| ESG | Northern Trust STOXX US ESG Select ETF | 0.43% | Jul 31, 2026 | Equity |
| IUSV | iShares Core S&P U.S. Value ETF | 0.42% | Nov 3, 2026 | Equity |
| MNZL | Manzil Russell Halal USA Broad Market ETF | 0.42% | Jul 31, 2026 | Equity |
| TEC | Harbor Transformative Technologies ETF | 0.42% | Jul 31, 2026 | Equity |
| QQH | HCM Defender 100 Index ETF | 0.40% | Jun 30, 2026 | Equity |
| RGLO | Russell Investments Global Equity ETF | 0.40% | Jun 30, 2026 | Equity |
| AVSU | Avantis Responsible U.S. Equity ETF | 0.40% | Nov 2, 2026 | Equity |
| LCDS | JPMorgan Fundamental Data Science Large Core ETF | 0.40% | Nov 3, 2026 | Equity |
| SUSA | iShares ESG Optimized MSCI USA ETF | 0.40% | Nov 3, 2026 | Equity |
| USSG | Xtrackers MSCI USA Selection Equity ETF | 0.40% | Aug 31, 2026 | Equity |
| AQLT | iShares MSCI Global Quality Factor ETF | 0.39% | Nov 3, 2026 | Equity |
| DSI | iShares ESG MSCI KLD 400 ETF | 0.39% | Nov 3, 2026 | Equity |
| SUSL | iShares ESG MSCI USA Leaders ETF | 0.39% | Nov 3, 2026 | Equity |
| JSTC | Adasina Social Justice All Cap Global ETF | 0.39% | Aug 31, 2026 | Equity |
| VUG | Vanguard Morningstar Growth ETF | 0.37% | Sep 30, 2026 | Equity |
| WINN | Harbor Long-Term Growers ETF | 0.37% | Jul 31, 2026 | Equity |
| GVUS | Goldman Sachs MarketBeta Russell 1000 Value Equity ETF | 0.37% | Aug 31, 2026 | Equity |
| NULC | Nuveen ESG Large-Cap ETF | 0.37% | Jul 31, 2026 | Equity |
| VONV | Vanguard Russell 1000 Value ETF | 0.37% | Sep 30, 2026 | Equity |
| SPUS | SP Funds S&P 500 Sharia Industry Exclusions ETF | 0.36% | Aug 31, 2026 | Equity |
| IWD | iShares Russell 1000 Value ETF | 0.36% | Nov 3, 2026 | Equity |
| IQSU | NYLIM Candriam U.S. Large Cap Equity ETF | 0.35% | Jul 31, 2026 | Equity |
| PRXG | Praxis Impact Large Cap Growth ETF | 0.35% | Jun 30, 2026 | Equity |
| HLAL | Wahed FTSE USA Shariah ETF | 0.35% | Aug 31, 2026 | Equity |
| SFTY | Horizon Managed Risk ETF | 0.34% | Aug 31, 2026 | Equity |
| STOX | Horizon Core Equity ETF | 0.34% | Aug 31, 2026 | Equity |
| JUSA | JPMorgan U.S. Research Enhanced Large Cap ETF | 0.34% | Nov 3, 2026 | Equity |
| NBCR | Neuberger Core Equity ETF | 0.34% | Aug 31, 2026 | Equity |
| SPXT | ProShares S&P 500 Ex-Technology ETF | 0.33% | Nov 3, 2026 | Equity |
| REVS | Columbia Research Enhanced Value ETF | 0.33% | Jul 31, 2026 | Equity |
| ESGG | Northern Trust STOXX Global ESG Select ETF | 0.32% | Jul 31, 2026 | Equity |
| QARP | Xtrackers Russell 1000 US Quality at a Reasonable Price ETF | 0.32% | Aug 31, 2026 | Equity |
| XMAG | Defiance Large Cap ex-Mag 7 ETF | 0.32% | Nov 4, 2026 | Equity |
| USNZ | Xtrackers Net Zero Pathway Paris Aligned US Equity ETF | 0.31% | Aug 31, 2026 | Equity |
| OALC | OneAscent Large Cap Core ETF | 0.30% | Aug 31, 2026 | Equity |
| WRND | NYLIM Global Equity R&D Leaders ETF | 0.30% | Jul 31, 2026 | Equity |
| ONEQ | Fidelity Nasdaq Composite Index ETF | 0.30% | Aug 31, 2026 | Equity |
| DFLV | Dimensional US Large Cap Value ETF | 0.30% | Jul 31, 2026 | Equity |
| MPLY | MONOPOLY ETF | 0.29% | Jul 31, 2026 | Equity |
| QLV | Northern Trust US Quality Low Volatility ETF | 0.29% | Jul 31, 2026 | Equity |
| EGLE | Global X S&P 500 U.S. Revenue Leaders ETF | 0.28% | Jul 31, 2026 | Equity |
| FAD | First Trust Multi Cap Growth AlphaDEX Fund | 0.27% | Nov 3, 2026 | Equity |
| ILCV | iShares Morningstar Value ETF | 0.27% | Nov 3, 2026 | Equity |
| MMTM | State Street SPDR S&P 1500 Momentum Tilt ETF | 0.27% | Nov 3, 2026 | Equity |
| TGRT | T. Rowe Price Growth ETF | 0.26% | Jun 30, 2026 | Equity |
| DSPY | Tema S&P 500 Historical Weight ETF Strategy | 0.26% | Nov 3, 2026 | Equity |
| ESGU | iShares ESG Aware MSCI USA ETF | 0.26% | Nov 3, 2026 | Equity |
| FEX | First Trust Large Cap Core AlphaDEX Fund | 0.26% | Nov 3, 2026 | Equity |
| PABU | iShares Paris-Aligned Climate Optimized MSCI USA ETF | 0.26% | Nov 3, 2026 | Equity |
| ACVF | American Conservative Values ETF | 0.25% | Jul 31, 2026 | Equity |
| BFOR | Barron's 400 ETF | 0.25% | Aug 31, 2026 | Equity |
| QVML | Invesco S&P 500 QVM Multi-factor ETF | 0.25% | Nov 3, 2026 | Equity |
| USCA | Xtrackers MSCI USA Climate Action Equity ETF | 0.25% | Aug 31, 2026 | Equity |
| HQGO | Hartford US Quality Growth ETF | 0.25% | Jul 31, 2026 | Equity |
| EGUS | iShares ESG Aware MSCI USA Growth ETF | 0.25% | Nov 3, 2026 | Equity |
| LCTU | iShares U.S. Carbon Transition Readiness Aware Active ETF | 0.25% | Nov 3, 2026 | Equity |
| STXG | Strive 1000 Growth ETF | 0.25% | Jun 30, 2026 | Equity |
| TOPC | iShares S&P 500 3% Capped ETF | 0.25% | Nov 3, 2026 | Equity |
| USCL | iShares Climate Conscious & Transition MSCI USA ETF | 0.25% | Nov 3, 2026 | Equity |
| XVV | iShares ESG Select Screened S&P 500 ETF | 0.25% | Nov 3, 2026 | Equity |
| LOPP | Gabelli Love Our Planet & People ETF | 0.25% | Jun 30, 2026 | Equity |
| MGC | Vanguard Morningstar Mega Cap ETF | 0.24% | Sep 30, 2026 | Equity |
| DFVE | DoubleLine Fortune 500 Equal Weight ETF | 0.24% | Jun 30, 2026 | Equity |
| IWL | iShares Russell Top 200 ETF | 0.24% | Nov 3, 2026 | Equity |
| SPXN | ProShares S&P 500 Ex-Financials ETF | 0.24% | Nov 3, 2026 | Equity |
| TVAL | T. Rowe Price Value ETF | 0.24% | Jun 30, 2026 | Equity |
| PQUS | Pictet AI Enhanced US Equity ETF | 0.24% | Jun 30, 2026 | Equity |
| KLMN | Invesco MSCI North America Climate ETF | 0.23% | Nov 3, 2026 | Equity |
| AAEQ | Alpha Architect US Equity 2 ETF | 0.23% | Jun 30, 2026 | Equity |
| CVLC | Calvert US Large-Cap Core Responsible Index ETF | 0.23% | Jun 30, 2026 | Equity |
| TSPA | T. Rowe Price U.S. Equity Research ETF | 0.23% | Jun 30, 2026 | Equity |
| GSEW | Goldman Sachs Equal Weight U.S. Large Cap Equity ETF | 0.23% | Aug 31, 2026 | Equity |
| JUST | Goldman Sachs JUST U.S. Large Cap Equity ETF | 0.22% | Aug 31, 2026 | Equity |
| ESGV | Vanguard ESG U.S. Stock ETF | 0.22% | Sep 30, 2026 | Equity |
| AAUA | Alpha Architect US Equity 3 ETF | 0.22% | Jun 30, 2026 | Equity |
| AAUS | Alpha Architect US Equity ETF | 0.22% | Jun 30, 2026 | Equity |
| SIZE | iShares MSCI USA Size Factor ETF | 0.22% | Nov 3, 2026 | Equity |
| GSUS | Goldman Sachs MarketBeta U.S. Equity ETF | 0.21% | Aug 31, 2026 | Equity |
| SPYX | State Street SPDR S&P 500 Fossil Fuel Reserves Free ETF | 0.21% | Nov 3, 2026 | Equity |
| EQL | Alps Equal Sector Weight ETF | 0.21% | Aug 31, 2026 | Equity |
| GXLC | Global X U.S. 500 ETF | 0.21% | Aug 31, 2026 | Equity |
| BBUS | JPMorgan BetaBuilders U.S. Equity ETF | 0.21% | Nov 3, 2026 | Equity |
| FINA | Fidelity MSCI North American Subset Index ETF | 0.21% | Jul 31, 2026 | Equity |
| MLRG | iShares MSCI USA ETF | 0.21% | Nov 3, 2026 | Equity |
| PWS | Pacer WealthShield ETF | 0.21% | Jul 31, 2026 | Equity |
| SPXE | ProShares S&P 500 Ex-Energy ETF | 0.21% | Nov 3, 2026 | Equity |
| USEW | Cambria US EW ETF | 0.21% | Aug 31, 2026 | Equity |
| PBUS | Invesco MSCI USA ETF | 0.21% | Nov 3, 2026 | Equity |
| IVV | iShares Core S&P 500 ETF | 0.21% | Nov 3, 2026 | Equity |
| SPY | SPDR S&P 500 ETF Trust | 0.21% | Nov 3, 2026 | Equity |
| SPYM | State Street SPDR Portfolio S&P 500 ETF | 0.21% | Nov 3, 2026 | Equity |
| VV | Vanguard Morningstar Large-Cap ETF | 0.21% | Sep 30, 2026 | Equity |
| ONOF | Global X Adaptive U.S. Risk Management ETF | 0.20% | Aug 31, 2026 | Equity |
| VOO | Vanguard S&P 500 ETF | 0.20% | Sep 30, 2026 | Equity |
| RAUS | RACWI US ETF | 0.20% | Jun 30, 2026 | Equity |
| SPYH | NEOS S&P 500 Hedged Equity Income ETF | 0.20% | Nov 3, 2026 | Equity |
| STXF | Strive 500 ETF | 0.20% | Jun 30, 2026 | Equity |
| RSP | Invesco S&P 500 Equal Weight ETF | 0.20% | Nov 3, 2026 | Equity |
| SCHX | Schwab U.S. Large-Cap ETF | 0.20% | Aug 31, 2026 | Equity |
| USPX | Franklin U.S. Equity Index ETF | 0.20% | Jun 30, 2026 | Equity |
| VFMF | Vanguard U.S. Multifactor ETF | 0.20% | Sep 30, 2026 | Equity |
| VSLU | Applied Finance Valuation Large Cap ETF | 0.20% | Jun 30, 2026 | Equity |
| GUSA | Goldman Sachs MarketBeta U.S. 1000 Equity ETF | 0.19% | Aug 31, 2026 | Equity |
| SCHK | Schwab 1000 Index ETF | 0.19% | Aug 31, 2026 | Equity |
| AVLC | Avantis U.S. Large Cap Equity ETF | 0.19% | Nov 2, 2026 | Equity |
| AVUQ | Avantis U.S. Quality ETF | 0.19% | Nov 2, 2026 | Equity |
| ENHU | iShares Enhanced Large Cap Core Active ETF | 0.19% | Nov 3, 2026 | Equity |
| EUSA | iShares MSCI USA Equal Weighted ETF | 0.19% | Nov 3, 2026 | Equity |
| IWB | iShares Russell 1000 ETF | 0.19% | Nov 3, 2026 | Equity |
| IWV | iShares Russell 3000 ETF | 0.19% | Nov 3, 2026 | Equity |
| IYY | iShares Dow Jones U.S. ETF | 0.19% | Nov 3, 2026 | Equity |
| BKLC | BNY Mellon US Large Cap Core Equity ETF | 0.19% | Jul 31, 2026 | Equity |
| SPTM | State Street SPDR Portfolio S&P 1500 Composite Stock Market ETF | 0.19% | Nov 3, 2026 | Equity |
| VONE | Vanguard Russell 1000 ETF | 0.19% | Sep 30, 2026 | Equity |
| PTLC | Pacer Trendpilot US Large Cap ETF | 0.19% | Jul 31, 2026 | Equity |
| SCHB | Schwab U.S. Broad Market ETF | 0.19% | Aug 31, 2026 | Equity |
| VOTE | TCW Transform 500 ETF | 0.19% | Jul 31, 2026 | Equity |
| VTHR | Vanguard Russell 3000 ETF | 0.18% | Sep 30, 2026 | Equity |
| VTI | Vanguard Morningstar Total Stock Market ETF | 0.18% | Sep 30, 2026 | Equity |
| ADME | Aptus Drawdown Managed Equity ETF | 0.18% | Jul 31, 2026 | Equity |
| APUE | ActivePassive U.S. Equity ETF | 0.18% | Aug 31, 2026 | Equity |
| AVUS | Avantis U.S. Equity ETF | 0.18% | Nov 3, 2026 | Equity |
| ITOT | iShares Core S&P Total U.S. Stock Market ETF | 0.18% | Nov 3, 2026 | Equity |
| JQUA | JPMorgan U.S. Quality Factor ETF | 0.18% | Nov 3, 2026 | Equity |
| TOV | JLens 500 Jewish Advocacy U.S. ETF | 0.18% | Jul 31, 2026 | Equity |
| VPX | Variant Perception Cycle Aware US Equity ETF | 0.18% | Aug 31, 2026 | Equity |
| RWLC | Rayliant NxtGen Multifactor US Equity ETF | 0.18% | Jun 30, 2026 | Equity |
| WAMA | WisdomTree U.S. Adaptive Moving Average Fund | 0.18% | Jun 30, 2026 | Equity |
| DFUS | Dimensional U.S. Equity Market ETF | 0.18% | Jul 31, 2026 | Equity |
| RECS | Columbia Research Enhanced Core ETF | 0.18% | Jul 31, 2026 | Equity |
| DFSU | Dimensional US Sustainability Core 1 ETF | 0.17% | Jul 31, 2026 | Equity |
| VOXP | Vox Populi ETF | 0.17% | Jul 31, 2026 | Equity |
| WCEO | Hypatia Women CEO ETF | 0.17% | Jul 31, 2026 | Equity |
| ACGR | American Century Large Cap Growth ETF | 0.17% | Aug 31, 2026 | Equity |
| QDPL | Pacer Metaurus US Large Cap Dividend Multiplier 400 ETF | 0.17% | Jul 31, 2026 | Equity |
| ROUS | Hartford Multifactor US Equity ETF | 0.17% | Jul 31, 2026 | Equity |
| BKLG | BNY Mellon US Large Cap Equity Growth ETF | 0.17% | Jul 31, 2026 | Equity |
| FLCC | Federated Hermes MDT Large Cap Core ETF | 0.16% | Aug 31, 2026 | Equity |
| TOK | iShares MSCI Kokusai ETF | 0.16% | Nov 3, 2026 | Equity |
| KLMT | Invesco MSCI Global Climate 500 ETF | 0.16% | Nov 3, 2026 | Equity |
| TILT | Northern Trust Morningstar US Market Factor Tilt ETF | 0.16% | Jul 31, 2026 | Equity |
| KOKU | Xtrackers MSCI Kokusai Equity ETF | 0.16% | Aug 31, 2026 | Equity |
| CFA | VictoryShares US 500 Volatility Wtd ETF | 0.15% | Jun 30, 2026 | Equity |
| CFO | VictoryShares US 500 Enhanced Volatility Wtd ETF | 0.15% | Jun 30, 2026 | Equity |
| DEUS | Xtrackers Russell US Multifactor ETF | 0.15% | Aug 31, 2026 | Equity |
| GQI | Natixis Gateway Quality Income ETF | 0.15% | Jun 30, 2026 | Equity |
| LGH | HCM Defender 500 Index ETF | 0.15% | Jun 30, 2026 | Equity |
| RSPA | Invesco S&P 500 Equal Weight Income Advantage ETF | 0.15% | Nov 3, 2026 | Equity |
| AVTM | Avantis Total Equity Markets ETF | 0.15% | Nov 2, 2026 | Equity |
| EPS | WisdomTree U.S. LargeCap Fund | 0.15% | Jun 30, 2026 | Equity |
| EVUS | iShares ESG Aware MSCI USA Value ETF | 0.15% | Nov 3, 2026 | Equity |
| HCMT | Direxion HCM Tactical Enhanced US ETF | 0.15% | Jul 31, 2026 | Equity |
| INRO | iShares U.S. Industry Rotation Active ETF | 0.15% | Nov 3, 2026 | Equity |
| URTH | iShares MSCI World ETF | 0.15% | Nov 3, 2026 | Equity |
| IUS | Invesco RAFI Strategic US ETF | 0.14% | Nov 3, 2026 | Equity |
| PRF | Invesco RAFI US 1000 ETF | 0.14% | Nov 3, 2026 | Equity |
| DFVX | Dimensional US Large Cap Vector ETF | 0.14% | Jul 31, 2026 | Equity |
| VFMO | Vanguard U.S. Momentum Factor ETF | 0.14% | Sep 30, 2026 | Equity |
| TACU | T. Rowe Price Active Core U.S. Equity ETF | 0.14% | Jun 30, 2026 | Equity |
| DFAU | Dimensional US Core Equity Market ETF | 0.13% | Jul 31, 2026 | Equity |
| MSLC | Morgan Stanley Pathway Large Cap Equity ETF | 0.13% | Aug 31, 2026 | Equity |
| NZAC | State Street SPDR MSCI ACWI Climate Paris Aligned ETF | 0.13% | Nov 3, 2026 | Equity |
| ACWI | iShares MSCI ACWI ETF | 0.13% | Nov 3, 2026 | Equity |
| ILCG | iShares Morningstar Growth ETF | 0.13% | Nov 3, 2026 | Equity |
| JHML | John Hancock Multifactor Large Cap ETF | 0.13% | Jun 30, 2026 | Equity |
| GSWO | Goldman Sachs ActiveBeta World Equity ETF | 0.13% | Aug 31, 2026 | Equity |
| CRBN | iShares Low Carbon Optimized MSCI ACWI ETF | 0.12% | Nov 3, 2026 | Equity |
| FNDX | Schwab Fundamental U.S. Large Company ETF | 0.12% | Aug 31, 2026 | Equity |
| ONEO | State Street SPDR Russell 1000 Momentum Focus ETF | 0.11% | Nov 3, 2026 | Equity |
| VT | Vanguard Total World Stock Index ETF | 0.11% | Sep 30, 2026 | Equity |
| FNDB | Schwab Fundamental U.S. Broad Market ETF | 0.11% | Aug 31, 2026 | Equity |
| LGDX | Intech S&P Large Cap Diversified Alpha ETF | 0.11% | Jul 31, 2026 | Equity |
| MFUS | PIMCO RAFI Dynamic Multi-Factor U.S. Equity ETF | 0.10% | Jun 30, 2026 | Equity |
| KOMP | State Street SPDR S&P Kensho New Economies Composite ETF | 0.10% | Nov 3, 2026 | Equity |
| GSLC | Goldman Sachs ActiveBeta U.S. Large Cap Equity ETF | 0.10% | Aug 31, 2026 | Equity |
| VLU | State Street SPDR S&P 1500 Value Tilt ETF | 0.10% | Nov 3, 2026 | Equity |
| RAA | SMI 3Fourteen Real Asset Allocation ETF | 0.10% | Jun 30, 2026 | Equity |
| DFAL | Dimensional US Large Cap Core Equity Market ETF | 0.10% | Jul 31, 2026 | Equity |
| EQAL | Invesco Russell 1000 Equal Weight ETF | 0.10% | Nov 3, 2026 | Equity |
| DCOR | US Core Equity 1 Portfolio ETF Class Shares | 0.09% | Jul 31, 2026 | Equity |
| DFAC | U.S. Core Equity 2 Portfolio ETF Class Shares | 0.09% | Jul 31, 2026 | Equity |
| HRSK | Toews Agility Shares Hedged Risk ETF | 0.07% | Jul 31, 2026 | Equity |
| RWL | Invesco S&P 500 Revenue ETF | 0.06% | Nov 3, 2026 | Equity |
| SPGM | State Street SPDR Portfolio MSCI Global Stock Market ETF | 0.06% | Nov 3, 2026 | Equity |
| DYNF | iShares U.S. Equity Factor Rotation Active ETF | 0.06% | Nov 3, 2026 | Equity |
| PRXV | Praxis Impact Large Cap Value ETF | 0.06% | Jun 30, 2026 | Equity |
| GSPY | Gotham Enhanced 500 ETF | 0.06% | Jun 30, 2026 | Equity |
| BRCE | MFS Blended Research Core Equity ETF | 0.05% | Aug 31, 2026 | Equity |
| MHIP | Milliman Healthcare Inflation Plus ETF | 0.05% | Jun 30, 2026 | Equity |
| GTPE | Goldman Sachs MSCI World Private Equity Return Tracker ETF | 0.04% | Aug 31, 2026 | Equity |
| DXUV | US Vector Equity Portfolio ETF Class Shares | 0.04% | Jul 31, 2026 | Equity |
| SPXD | Xtrackers S&P 500 Diversified Sector Weight ETF | 0.01% | Aug 31, 2026 | Equity |
| EBI | Longview Advantage ETF | 0.01% | Aug 31, 2026 | Equity |
| NPFE | NPF Core Equity ETF | Vertex Pharmaceuticals Inc (ticker VRTX, listed in US) is matched in every holdings book ETFIQ publishes, by its ticker and name. A share of the fund is the weight its issuer published, as of the Holdings filed date. Shares, preferred shares and debt are told by each fund’s N-PORT asset type. A fund holding only the company’s debt or preferred shares is listed under them, not counted as holding its shares. Options, swaps, futures and cash do not count as holding a company: a call option on a share is not the share. Funds whose book is gross exposure, not a portfolio, are left out.

Each row shows the date the fund last filed.

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### Questions people ask

Which ETFs hold Vertex Pharmaceuticals Inc? 322 thematic and core ETFs hold Vertex Pharmaceuticals Inc, by holdings dated Jun 30, 2026 to Nov 4, 2026. The largest positions are BBH at 7.98% of the fund on Nov 3, 2026, IBBQ at 7.65% of the fund on Nov 3, 2026 and IBB at 7.55% of the fund on Nov 3, 2026. 23 income and other funds on it are listed apart.

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Source: ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.
Cite: ETFIQ, ETFs holding Vertex Pharmaceuticals Inc, data as of Nov 5, 2026. https://etfiq.com/holdings/vrtx/
Licence: https://etfiq.com/license/ Data ETFIQ computes is free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms.
HTML: https://etfiq.com/holdings/vrtx/