# SYRE ETFs: 67 Funds That Hold Spyre Therapeutics Inc

> 67 thematic and core ETFs hold Spyre Therapeutics Inc (SYRE). LFSC holds the most, at 6.70% of the fund on Aug 31, 2026.

Data as of Nov 5, 2026. Rebuilt every trading night.

## ETFs that hold Spyre Therapeutics Inc

67 thematic and core ETFs hold Spyre Therapeutics Inc , by holdings dated Jun 30, 2026 to Nov 3, 2026 . LFSC holds the most, at 6.70% of the fund on Aug 31, 2026 . The next largest are XBI (1.67%) and MMSC (1.16%).

2 income and other funds on it are listed below.

### Thematic and core funds that hold it

| Fund | Name | Share of the fund | Holdings filed | Asset |
| --- | --- | --- | --- | --- |
| LFSC | F/m Emerald Life Sciences Innovation ETF | 6.70% | Aug 31, 2026 | Equity |
| XBI | State Street SPDR S&P Biotech ETF | 1.67% | Nov 3, 2026 | Equity |
| MMSC | First Trust Multi-Manager Small Cap Opportunities ETF | 1.16% | Nov 3, 2026 | Equity |
| DWAS | Invesco Dorsey Wright SmallCap Momentum ETF | 0.86% | Nov 3, 2026 | Equity |
| BBC | Virtus Biotech Clinical Trials ETF | 0.81% | Jul 31, 2026 | Equity |
| GDOC | Goldman Sachs Future Health Care Equity ETF | 0.77% | Aug 31, 2026 | Equity |
| SGRW | Harbor Active Small Cap Growth ETF | 0.73% | Jul 31, 2026 | Equity |
| FDMO | Fidelity Momentum Factor ETF | 0.70% | Jul 31, 2026 | Equity |
| GSC | Goldman Sachs Small Cap Equity ETF | 0.61% | Aug 31, 2026 | Equity |
| IBBQ | Invesco Nasdaq Biotechnology ETF | 0.56% | Nov 3, 2026 | Equity |
| ESSC | Eventide Small Cap ETF | 0.55% | Jul 31, 2026 | Equity |
| IBB | iShares Biotechnology ETF | 0.54% | Nov 3, 2026 | Equity |
| FTXH | First Trust Nasdaq Pharmaceuticals ETF | 0.52% | Nov 3, 2026 | Equity |
| IWO | iShares Russell 2000 Growth ETF | 0.51% | Nov 3, 2026 | Equity |
| JDOC | JPMorgan Healthcare Leaders ETF | 0.50% | Nov 3, 2026 | Equity |
| SCDS | JPMorgan Fundamental Data Science Small Core ETF | 0.48% | Nov 3, 2026 | Equity |
| FMED | Fidelity Disruptive Medicine ETF | 0.45% | Aug 31, 2026 | Equity |
| VTWG | Vanguard Russell 2000 Growth ETF | 0.44% | Sep 30, 2026 | Equity |
| CGMM | Capital Group U.S. Small and Mid Cap ETF | 0.34% | Aug 31, 2026 | Equity |
| TNXT | T. Rowe Price Innovation Leaders ETF | 0.33% | Jun 30, 2026 | Equity |
| BBSC | JPMorgan BetaBuilders U.S. Small Cap Equity ETF | 0.31% | Nov 3, 2026 | Equity |
| KBFR | Innovator U.S. Small Cap Managed 10 Buffer ETF | 0.29% | Jul 31, 2026 | Equity |
| STXK | Strive Small-Cap ETF | 0.29% | Jun 30, 2026 | Equity |
| BKSE | BNY Mellon US Small Cap Core Equity ETF | 0.28% | Jul 31, 2026 | Equity |
| PWS | Pacer WealthShield ETF | 0.25% | Jul 31, 2026 | Equity |
| IWM | iShares Russell 2000 ETF | 0.25% | Nov 3, 2026 | Equity |
| RUSC | Russell Investments U.S. Small Cap Equity ETF | 0.25% | Jun 30, 2026 | Equity |
| RFLR | Innovator U.S. Small Cap Managed Floor ETF | 0.25% | Jul 31, 2026 | Equity |
| RSSL | Global X Russell 2000 ETF | 0.23% | Jul 31, 2026 | Equity |
| VTWO | Vanguard Russell 2000 ETF | 0.22% | Sep 30, 2026 | Equity |
| RESM | Columbia Research Enhanced Small Cap ETF | 0.22% | Jun 30, 2026 | Equity |
| USVM | VictoryShares US Small Mid Cap Value Momentum ETF | 0.21% | Jun 30, 2026 | Equity |
| TMED | T. Rowe Price Health Care ETF | 0.20% | Jun 30, 2026 | Equity |
| VFMO | Vanguard U.S. Momentum Factor ETF | 0.18% | Sep 30, 2026 | Equity |
| MSSM | Morgan Stanley Pathway Small-Mid Cap Equity ETF | 0.18% | Aug 31, 2026 | Equity |
| VBR | Vanguard Morningstar Small-Cap Value ETF | 0.17% | Sep 30, 2026 | Equity |
| ISCV | iShares Morningstar Small-Cap Value ETF | 0.16% | Nov 3, 2026 | Equity |
| SCHA | Schwab U.S. Small-Cap ETF | 0.14% | Aug 31, 2026 | Equity |
| GSSC | GS ActiveBeta U.S. Small Cap Equity ETF | 0.14% | Aug 31, 2026 | Equity |
| ISCB | | 0.12% | Jul 31, 2026 | Equity |
| ESML | iShares ESG Aware MSCI USA Small-Cap ETF | 0.10% | Nov 3, 2026 | Equity |
| JGRO | JPMorgan Active Growth ETF | 0.10% | Nov 3, 2026 | Equity |
| VB | Vanguard Morningstar Small-Cap ETF | 0.09% | Sep 30, 2026 | Equity |
| MSML | iShares MSCI USA Small-Cap ETF | 0.09% | Nov 3, 2026 | Equity |
| SMLF | iShares U.S. Small-Cap Equity Factor ETF | 0.09% | Nov 3, 2026 | Equity |
| ISCG | iShares Morningstar Small-Cap Growth ETF | 0.09% | Nov 3, 2026 | Equity |
| TMSL | T. Rowe Price Small-Mid Cap ETF | 0.09% | Jun 30, 2026 | Equity |
| VXF | Vanguard Extended Market ETF | 0.09% | Sep 30, 2026 | Equity |
| FHLC | Fidelity MSCI Health Care Index ETF | 0.08% | Jul 31, 2026 | Equity |
| VHT | Vanguard Health Care ETF | 0.08% | Sep 30, 2026 | Equity |
| PRFZ | Invesco RAFI US 1500 Small-Mid ETF | 0.06% | Nov 3, 2026 | Equity |
| AVIE | Avantis Inflation Focused Equity ETF | 0.06% | Nov 2, 2026 | Equity |
| WSML | iShares MSCI World Small-Cap ETF | 0.06% | Nov 3, 2026 | Equity |
| SMMV | iShares MSCI USA Small-Cap Min Vol Factor ETF | 0.06% | Nov 3, 2026 | Equity |
| ONEQ | Fidelity Nasdaq Composite Index ETF | 0.02% | Aug 31, 2026 | Equity |
| TILT | Northern Trust Morningstar US Market Factor Tilt ETF | 0.02% | Jul 31, 2026 | Equity |
| ESGV | Vanguard ESG U.S. Stock ETF | 0.01% | Sep 30, 2026 | Equity |
| AVLC | Avantis U.S. Large Cap Equity ETF | 0.01% | Nov 2, 2026 | Equity |
| GUSA | Goldman Sachs MarketBeta U.S. 1000 Equity ETF | 0.01% | Aug 31, 2026 | Equity |
| ITOT | iShares Core S&P Total U.S. Stock Market ETF | 0.01% | Nov 3, 2026 | Equity |
| IWV | iShares Russell 3000 ETF | 0.01% | Nov 3, 2026 | Equity |
| VTI | Vanguard Morningstar Total Stock Market ETF | 0.01% | Sep 30, 2026 | Equity |
| GTPE | Goldman Sachs MSCI World Private Equity Return Tracker ETF | 0.01% | Aug 31, 2026 | Equity |
| SCHB | Schwab U.S. Broad Market ETF | 0.01% | Aug 31, 2026 | Equity |
| VTHR | Vanguard Russell 3000 ETF | 0.01% | Sep 30, 2026 | Equity |
| VT | Vanguard Total World Stock Index ETF | 0.01% | Sep 30, 2026 | Equity |
| SPGM | State Street SPDR Portfolio MSCI Global Stock Market ETF | Spyre Therapeutics Inc (ticker SYRE, listed in US) is matched in every holdings book ETFIQ publishes, by its ticker and name. A share of the fund is the weight its issuer published, as of the Holdings filed date. Shares, preferred shares and debt are told by each fund’s N-PORT asset type. A fund holding only the company’s debt or preferred shares is listed under them, not counted as holding its shares. Options, swaps, futures and cash do not count as holding a company: a call option on a share is not the share. Funds whose book is gross exposure, not a portfolio, are left out.

Each row shows the date the fund last filed.

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### Questions people ask

Which ETFs hold Spyre Therapeutics Inc? 67 thematic and core ETFs hold Spyre Therapeutics Inc, by holdings dated Jun 30, 2026 to Nov 3, 2026. The largest positions are LFSC at 6.70% of the fund on Aug 31, 2026, XBI at 1.67% of the fund on Nov 3, 2026 and MMSC at 1.16% of the fund on Nov 3, 2026. 2 income and other funds on it are listed apart.

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Source: ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.
Cite: ETFIQ, ETFs holding SPYRE THERAPEUTICS INC, data as of Nov 5, 2026. https://etfiq.com/holdings/syre/
Licence: https://etfiq.com/license/ Data ETFIQ computes is free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms.
HTML: https://etfiq.com/holdings/syre/