{"url":"https://etfiq.com/holdings/syre/","section":"holdings","title":"SYRE ETFs: 67 Funds That Hold Spyre Therapeutics Inc | ETFIQ","description":"67 thematic and core ETFs hold Spyre Therapeutics Inc (SYRE). LFSC holds the most, at 6.70% of the fund on Aug 31, 2026.","as_of":"Nov 5, 2026","structured_data":[{"@type":"Dataset","@id":"https://etfiq.com/holdings/syre#data","name":"ETFs holding Spyre Therapeutics Inc","description":"Every US listed ETF that holds Spyre Therapeutics Inc, with each fund\u2019s published weight and filing date.","creator":{"@id":"https://etfiq.com/#org"},"isAccessibleForFree":true,"variableMeasured":["Share of fund","Holdings filing date"],"license":"https://etfiq.com/license/","publisher":{"@id":"https://etfiq.com/#org"},"inLanguage":"en","creativeWorkStatus":"Published","distribution":[{"@type":"DataDownload","encodingFormat":"application/json","contentUrl":"https://etfiq.com/data/alternatives.json"},{"@type":"DataDownload","encodingFormat":"application/json","contentUrl":"https://etfiq.com/data/core.json"},{"@type":"DataDownload","encodingFormat":"application/json","contentUrl":"https://etfiq.com/data/crypto.json"},{"@type":"DataDownload","encodingFormat":"application/json","contentUrl":"https://etfiq.com/data/funds.json"},{"@type":"DataDownload","encodingFormat":"application/json","contentUrl":"https://etfiq.com/data/income.json"},{"@type":"DataDownload","encodingFormat":"application/json","contentUrl":"https://etfiq.com/data/leverage.json"},{"@type":"DataDownload","encodingFormat":"application/json","contentUrl":"https://etfiq.com/data/thematic.json"}]},{"@type":"FAQPage","mainEntity":[{"@type":"Question","name":"Which ETFs hold Spyre Therapeutics Inc?","acceptedAnswer":{"@type":"Answer","text":"67 thematic and core ETFs hold Spyre Therapeutics Inc, by holdings dated Jun 30, 2026 to Nov 3, 2026. The largest positions are LFSC at 6.70% of the fund on Aug 31, 2026, XBI at 1.67% of the fund on Nov 3, 2026 and MMSC at 1.16% of the fund on Nov 3, 2026. 2 income and other funds on it are listed apart."}}]},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"ETFIQ","item":"https://etfiq.com/"},{"@type":"ListItem","position":2,"name":"Holdings","item":"https://etfiq.com/holdings/"},{"@type":"ListItem","position":3,"name":"SPYRE THERAPEUTICS INC","item":"https://etfiq.com/holdings/syre/"}]},{"@type":"WebPage","name":"SYRE ETFs: 67 Funds That Hold Spyre Therapeutics Inc","description":"67 thematic and core ETFs hold Spyre Therapeutics Inc (SYRE). LFSC holds the most, at 6.70% of the fund on Aug 31, 2026.","url":"https://etfiq.com/holdings/syre/","dateModified":"2026-11-04","isPartOf":{"@type":"WebSite","name":"ETFIQ","url":"https://etfiq.com"},"speakable":{"@type":"SpeakableSpecification","cssSelector":[".lede",".faq"]},"publisher":{"@id":"https://etfiq.com/#org"}}],"characters":6906,"truncated":false,"content":"ETFIQ / Holdings / SPYRE THERAPEUTICS INC \n \n ETFs that hold Spyre Therapeutics Inc\n 67 thematic and core ETFs hold Spyre Therapeutics Inc , by holdings dated Jun 30, 2026 to Nov 3, 2026 . LFSC holds the most, at 6.70% of the fund on Aug 31, 2026 . The next largest are XBI (1.67%) and MMSC (1.16%). \n 2 income and other funds on it are listed below.\n Thematic and core funds that hold it\n Fund Name Share of the fund Holdings filed Asset \n LFSC F/m Emerald Life Sciences Innovation ETF 6.70% Aug 31, 2026 Equity \n XBI State Street SPDR S&P Biotech ETF 1.67% Nov 3, 2026 Equity \n MMSC First Trust Multi-Manager Small Cap Opportunities ETF 1.16% Nov 3, 2026 Equity \n DWAS Invesco Dorsey Wright SmallCap Momentum ETF 0.86% Nov 3, 2026 Equity \n BBC Virtus Biotech Clinical Trials ETF 0.81% Jul 31, 2026 Equity \n GDOC Goldman Sachs Future Health Care Equity ETF 0.77% Aug 31, 2026 Equity \n SGRW Harbor Active Small Cap Growth ETF 0.73% Jul 31, 2026 Equity \n FDMO Fidelity Momentum Factor ETF 0.70% Jul 31, 2026 Equity \n GSC Goldman Sachs Small Cap Equity ETF 0.61% Aug 31, 2026 Equity \n IBBQ Invesco Nasdaq Biotechnology ETF 0.56% Nov 3, 2026 Equity \n ESSC Eventide Small Cap ETF 0.55% Jul 31, 2026 Equity \n IBB iShares Biotechnology ETF 0.54% Nov 3, 2026 Equity \n FTXH First Trust Nasdaq Pharmaceuticals ETF 0.52% Nov 3, 2026 Equity \n IWO iShares Russell 2000 Growth ETF 0.51% Nov 3, 2026 Equity \n JDOC JPMorgan Healthcare Leaders ETF 0.50% Nov 3, 2026 Equity \n SCDS JPMorgan Fundamental Data Science Small Core ETF 0.48% Nov 3, 2026 Equity \n FMED Fidelity Disruptive Medicine ETF 0.45% Aug 31, 2026 Equity \n VTWG Vanguard Russell 2000 Growth ETF 0.44% Sep 30, 2026 Equity \n CGMM Capital Group U.S. Small and Mid Cap ETF 0.34% Aug 31, 2026 Equity \n TNXT T. Rowe Price Innovation Leaders ETF 0.33% Jun 30, 2026 Equity \n BBSC JPMorgan BetaBuilders U.S. Small Cap Equity ETF 0.31% Nov 3, 2026 Equity \n KBFR Innovator U.S. Small Cap Managed 10 Buffer ETF 0.29% Jul 31, 2026 Equity \n STXK Strive Small-Cap ETF 0.29% Jun 30, 2026 Equity \n BKSE BNY Mellon US Small Cap Core Equity ETF 0.28% Jul 31, 2026 Equity \n PWS Pacer WealthShield ETF 0.25% Jul 31, 2026 Equity \n IWM iShares Russell 2000 ETF 0.25% Nov 3, 2026 Equity \n RUSC Russell Investments U.S. Small Cap Equity ETF 0.25% Jun 30, 2026 Equity \n RFLR Innovator U.S. Small Cap Managed Floor ETF 0.25% Jul 31, 2026 Equity \n RSSL Global X Russell 2000 ETF 0.23% Jul 31, 2026 Equity \n VTWO Vanguard Russell 2000 ETF 0.22% Sep 30, 2026 Equity \n RESM Columbia Research Enhanced Small Cap ETF 0.22% Jun 30, 2026 Equity \n USVM VictoryShares US Small Mid Cap Value Momentum ETF 0.21% Jun 30, 2026 Equity \n TMED T. Rowe Price Health Care ETF 0.20% Jun 30, 2026 Equity \n VFMO Vanguard U.S. Momentum Factor ETF 0.18% Sep 30, 2026 Equity \n MSSM Morgan Stanley Pathway Small-Mid Cap Equity ETF 0.18% Aug 31, 2026 Equity \n VBR Vanguard Morningstar Small-Cap Value ETF 0.17% Sep 30, 2026 Equity \n ISCV iShares Morningstar Small-Cap Value ETF 0.16% Nov 3, 2026 Equity \n SCHA Schwab U.S. Small-Cap ETF 0.14% Aug 31, 2026 Equity \n GSSC GS ActiveBeta U.S. Small Cap Equity ETF 0.14% Aug 31, 2026 Equity \n ISCB 0.12% Jul 31, 2026 Equity \n ESML iShares ESG Aware MSCI USA Small-Cap ETF 0.10% Nov 3, 2026 Equity \n JGRO JPMorgan Active Growth ETF 0.10% Nov 3, 2026 Equity \n VB Vanguard Morningstar Small-Cap ETF 0.09% Sep 30, 2026 Equity \n MSML iShares MSCI USA Small-Cap ETF 0.09% Nov 3, 2026 Equity \n SMLF iShares U.S. Small-Cap Equity Factor ETF 0.09% Nov 3, 2026 Equity \n ISCG iShares Morningstar Small-Cap Growth ETF 0.09% Nov 3, 2026 Equity \n TMSL T. Rowe Price Small-Mid Cap ETF 0.09% Jun 30, 2026 Equity \n VXF Vanguard Extended Market ETF 0.09% Sep 30, 2026 Equity \n FHLC Fidelity MSCI Health Care Index ETF 0.08% Jul 31, 2026 Equity \n VHT Vanguard Health Care ETF 0.08% Sep 30, 2026 Equity \n PRFZ Invesco RAFI US 1500 Small-Mid ETF 0.06% Nov 3, 2026 Equity \n AVIE Avantis Inflation Focused Equity ETF 0.06% Nov 2, 2026 Equity \n WSML iShares MSCI World Small-Cap ETF 0.06% Nov 3, 2026 Equity \n SMMV iShares MSCI USA Small-Cap Min Vol Factor ETF 0.06% Nov 3, 2026 Equity \n ONEQ Fidelity Nasdaq Composite Index ETF 0.02% Aug 31, 2026 Equity \n TILT Northern Trust Morningstar US Market Factor Tilt ETF 0.02% Jul 31, 2026 Equity \n ESGV Vanguard ESG U.S. Stock ETF 0.01% Sep 30, 2026 Equity \n AVLC Avantis U.S. Large Cap Equity ETF 0.01% Nov 2, 2026 Equity \n GUSA Goldman Sachs MarketBeta U.S. 1000 Equity ETF 0.01% Aug 31, 2026 Equity \n ITOT iShares Core S&P Total U.S. Stock Market ETF 0.01% Nov 3, 2026 Equity \n IWV iShares Russell 3000 ETF 0.01% Nov 3, 2026 Equity \n VTI Vanguard Morningstar Total Stock Market ETF 0.01% Sep 30, 2026 Equity \n GTPE Goldman Sachs MSCI World Private Equity Return Tracker ETF 0.01% Aug 31, 2026 Equity \n SCHB Schwab U.S. Broad Market ETF 0.01% Aug 31, 2026 Equity \n VTHR Vanguard Russell 3000 ETF 0.01% Sep 30, 2026 Equity \n VT Vanguard Total World Stock Index ETF 0.01% Sep 30, 2026 Equity \n SPGM State Street SPDR Portfolio MSCI Global Stock Market ETF Nov 3, 2026 Equity \n Income and other funds that hold it\n Fund Name Share of the fund Holdings filed Category \n FTKI First Trust Small Cap BuyWrite Income ETF 0.30% Nov 3, 2026 Income \n ITWO ProShares Russell 2000 High Income ETF 0.19% Aug 31, 2026 Income \n What this counts\n Spyre Therapeutics Inc (ticker SYRE, listed in US) is matched in every holdings book ETFIQ publishes, by its ticker and name. A share of the fund is the weight its issuer published, as of the Holdings filed date. Shares, preferred shares and debt are told by each fund\u2019s N-PORT asset type. A fund holding only the company\u2019s debt or preferred shares is listed under them, not counted as holding its shares. Options, swaps, futures and cash do not count as holding a company: a call option on a share is not the share. Funds whose book is gross exposure, not a portfolio, are left out.\n Each row shows the date the fund last filed.\n Look up another company .\n Questions people ask\n Which ETFs hold Spyre Therapeutics Inc? 67 thematic and core ETFs hold Spyre Therapeutics Inc, by holdings dated Jun 30, 2026 to Nov 3, 2026. The largest positions are LFSC at 6.70% of the fund on Aug 31, 2026, XBI at 1.67% of the fund on Nov 3, 2026 and MMSC at 1.16% of the fund on Nov 3, 2026. 2 income and other funds on it are listed apart. \n Cite this page. ETFIQ, ETFs holding SPYRE THERAPEUTICS INC, data as of Nov 5, 2026. https://etfiq.com/holdings/syre/ Free to use with attribution for data ETFIQ computes; issuer data stays under its owner's terms. The underlying files are at Open data .\n Other forms Plain ETFIQ, ETFs holding SPYRE THERAPEUTICS INC, data as of Nov 5, 2026. https://etfiq.com/holdings/syre/ APA ETFIQ. (Nov 5, 2026). ETFs holding SPYRE THERAPEUTICS INC. Retrieved from https://etfiq.com/holdings/syre/ Markdown [ETFs holding SPYRE THERAPEUTICS INC (ETFIQ, Nov 5, 2026)](https://etfiq.com/holdings/syre/)","source":"ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.","publisher":{"@id":"https://etfiq.com/#org","name":"ETFIQ","url":"https://etfiq.com"},"license":"https://etfiq.com/license/","license_text":"Data ETFIQ computes is free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms.","citation":"ETFIQ, ETFs holding SPYRE THERAPEUTICS INC, data as of Nov 5, 2026. https://etfiq.com/holdings/syre/"}