# SEPN ETFs: 43 Funds That Hold Septerna Inc > 43 thematic and core ETFs hold Septerna Inc (SEPN). XPH holds the most, at 2.22% of the fund on Nov 3, 2026. Weights and filing dates for every holder. Data as of Nov 5, 2026. Rebuilt every trading night. ## ETFs that hold Septerna Inc 43 thematic and core ETFs hold Septerna Inc , by holdings dated Jun 30, 2026 to Nov 3, 2026 . XPH holds the most, at 2.22% of the fund on Nov 3, 2026 . The next largest are FYC (0.72%) and MMSC (0.69%). 1 income and other fund on it is listed below. ### Thematic and core funds that hold it | Fund | Name | Share of the fund | Holdings filed | Asset | | --- | --- | --- | --- | --- | | XPH | State Street SPDR S&P Pharmaceuticals ETF | 2.22% | Nov 3, 2026 | Equity | | FYC | First Trust Small Cap Growth AlphaDEX Fund | 0.72% | Nov 3, 2026 | Equity | | MMSC | First Trust Multi-Manager Small Cap Opportunities ETF | 0.69% | Nov 3, 2026 | Equity | | BBC | Virtus Biotech Clinical Trials ETF | 0.64% | Jul 31, 2026 | Equity | | FYX | First Trust Small Cap Core AlphaDEX Fund | 0.34% | Nov 3, 2026 | Equity | | AFSM | First Trust Active Factor Small Cap ETF | 0.32% | Nov 3, 2026 | Equity | | IHE | iShares U.S. Pharmaceuticals ETF | 0.22% | Nov 3, 2026 | Equity | | SQLV | Royce Quant Small-Cap Quality Value ETF | 0.18% | Jun 30, 2026 | Equity | | SYZ | Lazard US Systematic Small Cap Equity ETF | 0.17% | Jun 30, 2026 | Equity | | FSCC | Federated Hermes MDT Small Cap Core ETF | 0.16% | Aug 31, 2026 | Equity | | ACSG | American Century Small Cap Growth Insights ETF | 0.15% | Aug 31, 2026 | Equity | | FAD | First Trust Multi Cap Growth AlphaDEX Fund | 0.15% | Nov 3, 2026 | Equity | | JPSE | JPMorgan Diversified Return U.S. Small Cap Equity ETF | 0.15% | Nov 3, 2026 | Equity | | IBBQ | Invesco Nasdaq Biotechnology ETF | 0.13% | Nov 3, 2026 | Equity | | VFMO | Vanguard U.S. Momentum Factor ETF | 0.10% | Sep 30, 2026 | Equity | | IBB | iShares Biotechnology ETF | 0.09% | Nov 3, 2026 | Equity | | AVSC | Avantis U.S. Small Cap Equity ETF | 0.08% | Nov 2, 2026 | Equity | | RESM | Columbia Research Enhanced Small Cap ETF | 0.04% | Jun 30, 2026 | Equity | | IWO | iShares Russell 2000 Growth ETF | 0.04% | Nov 3, 2026 | Equity | | GSSC | GS ActiveBeta U.S. Small Cap Equity ETF | 0.04% | Aug 31, 2026 | Equity | | VTWG | Vanguard Russell 2000 Growth ETF | 0.04% | Sep 30, 2026 | Equity | | ISCG | iShares Morningstar Small-Cap Growth ETF | 0.03% | Nov 3, 2026 | Equity | | IWM | iShares Russell 2000 ETF | 0.03% | Nov 3, 2026 | Equity | | VTWO | Vanguard Russell 2000 ETF | 0.03% | Sep 30, 2026 | Equity | | RSSL | Global X Russell 2000 ETF | 0.02% | Jul 31, 2026 | Equity | | IWN | iShares Russell 2000 Value ETF | 0.02% | Nov 3, 2026 | Equity | | OMFS | Invesco Russell 2000 Dynamic Multifactor ETF | 0.02% | Nov 3, 2026 | Equity | | PRFZ | Invesco RAFI US 1500 Small-Mid ETF | 0.02% | Nov 3, 2026 | Equity | | SCHA | Schwab U.S. Small-Cap ETF | 0.02% | Aug 31, 2026 | Equity | | VTWV | Vanguard Russell 2000 Value ETF | 0.02% | Sep 30, 2026 | Equity | | ISCB | | 0.01% | Jul 31, 2026 | Equity | | MSML | iShares MSCI USA Small-Cap ETF | 0.01% | Nov 3, 2026 | Equity | | VXF | Vanguard Extended Market ETF | 0.01% | Sep 30, 2026 | Equity | | WSML | iShares MSCI World Small-Cap ETF | 0.01% | Nov 3, 2026 | Equity | | VHT | Vanguard Health Care ETF | 0.01% | Sep 30, 2026 | Equity | | ONEQ | Fidelity Nasdaq Composite Index ETF | 0.01% | Aug 31, 2026 | Equity | | FHLC | Fidelity MSCI Health Care Index ETF | 0.01% | Jul 31, 2026 | Equity | | MSSM | Morgan Stanley Pathway Small-Mid Cap Equity ETF | Septerna Inc (ticker SEPN, listed in US) is matched in every holdings book ETFIQ publishes, by its ticker and name. A share of the fund is the weight its issuer published, as of the Holdings filed date. Shares, preferred shares and debt are told by each fund’s N-PORT asset type. A fund holding only the company’s debt or preferred shares is listed under them, not counted as holding its shares. Options, swaps, futures and cash do not count as holding a company: a call option on a share is not the share. Funds whose book is gross exposure, not a portfolio, are left out. Each row shows the date the fund last filed. Look up another company . ### Questions people ask Which ETFs hold Septerna Inc? 43 thematic and core ETFs hold Septerna Inc, by holdings dated Jun 30, 2026 to Nov 3, 2026. The largest positions are XPH at 2.22% of the fund on Nov 3, 2026, FYC at 0.72% of the fund on Nov 3, 2026 and MMSC at 0.69% of the fund on Nov 3, 2026. 1 income and other fund on it is listed apart. --- Source: ETFIQ, independent ETF data. Recomputed nightly from public filings and prices. Cite: ETFIQ, ETFs holding Septerna Inc, data as of Nov 5, 2026. https://etfiq.com/holdings/sepn/ Licence: https://etfiq.com/license/ Data ETFIQ computes is free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms. HTML: https://etfiq.com/holdings/sepn/