{"url":"https://etfiq.com/holdings/sepn/","section":"holdings","title":"SEPN ETFs: 43 Funds That Hold Septerna Inc | ETFIQ","description":"43 thematic and core ETFs hold Septerna Inc (SEPN). XPH holds the most, at 2.22% of the fund on Nov 3, 2026. Weights and filing dates for every holder.","as_of":"Nov 5, 2026","structured_data":[{"@type":"Dataset","@id":"https://etfiq.com/holdings/sepn#data","name":"ETFs holding Septerna Inc","description":"Every US listed ETF that holds Septerna Inc, with each fund\u2019s published weight and filing date.","creator":{"@id":"https://etfiq.com/#org"},"isAccessibleForFree":true,"variableMeasured":["Share of fund","Holdings filing date"],"license":"https://etfiq.com/license/","publisher":{"@id":"https://etfiq.com/#org"},"inLanguage":"en","creativeWorkStatus":"Published","distribution":[{"@type":"DataDownload","encodingFormat":"application/json","contentUrl":"https://etfiq.com/data/alternatives.json"},{"@type":"DataDownload","encodingFormat":"application/json","contentUrl":"https://etfiq.com/data/core.json"},{"@type":"DataDownload","encodingFormat":"application/json","contentUrl":"https://etfiq.com/data/crypto.json"},{"@type":"DataDownload","encodingFormat":"application/json","contentUrl":"https://etfiq.com/data/funds.json"},{"@type":"DataDownload","encodingFormat":"application/json","contentUrl":"https://etfiq.com/data/income.json"},{"@type":"DataDownload","encodingFormat":"application/json","contentUrl":"https://etfiq.com/data/leverage.json"},{"@type":"DataDownload","encodingFormat":"application/json","contentUrl":"https://etfiq.com/data/thematic.json"}]},{"@type":"FAQPage","mainEntity":[{"@type":"Question","name":"Which ETFs hold Septerna Inc?","acceptedAnswer":{"@type":"Answer","text":"43 thematic and core ETFs hold Septerna Inc, by holdings dated Jun 30, 2026 to Nov 3, 2026. The largest positions are XPH at 2.22% of the fund on Nov 3, 2026, FYC at 0.72% of the fund on Nov 3, 2026 and MMSC at 0.69% of the fund on Nov 3, 2026. 1 income and other fund on it is listed apart."}}]},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"ETFIQ","item":"https://etfiq.com/"},{"@type":"ListItem","position":2,"name":"Holdings","item":"https://etfiq.com/holdings/"},{"@type":"ListItem","position":3,"name":"Septerna Inc","item":"https://etfiq.com/holdings/sepn/"}]},{"@type":"WebPage","name":"SEPN ETFs: 43 Funds That Hold Septerna Inc","description":"43 thematic and core ETFs hold Septerna Inc (SEPN). XPH holds the most, at 2.22% of the fund on Nov 3, 2026. Weights and filing dates for every holder.","url":"https://etfiq.com/holdings/sepn/","dateModified":"2026-11-04","isPartOf":{"@type":"WebSite","name":"ETFIQ","url":"https://etfiq.com"},"speakable":{"@type":"SpeakableSpecification","cssSelector":[".lede",".faq"]},"publisher":{"@id":"https://etfiq.com/#org"}}],"characters":5010,"truncated":false,"content":"ETFIQ / Holdings / Septerna Inc \n \n ETFs that hold Septerna Inc\n 43 thematic and core ETFs hold Septerna Inc , by holdings dated Jun 30, 2026 to Nov 3, 2026 . XPH holds the most, at 2.22% of the fund on Nov 3, 2026 . The next largest are FYC (0.72%) and MMSC (0.69%). \n 1 income and other fund on it is listed below.\n Thematic and core funds that hold it\n Fund Name Share of the fund Holdings filed Asset \n XPH State Street SPDR S&P Pharmaceuticals ETF 2.22% Nov 3, 2026 Equity \n FYC First Trust Small Cap Growth AlphaDEX Fund 0.72% Nov 3, 2026 Equity \n MMSC First Trust Multi-Manager Small Cap Opportunities ETF 0.69% Nov 3, 2026 Equity \n BBC Virtus Biotech Clinical Trials ETF 0.64% Jul 31, 2026 Equity \n FYX First Trust Small Cap Core AlphaDEX Fund 0.34% Nov 3, 2026 Equity \n AFSM First Trust Active Factor Small Cap ETF 0.32% Nov 3, 2026 Equity \n IHE iShares U.S. Pharmaceuticals ETF 0.22% Nov 3, 2026 Equity \n SQLV Royce Quant Small-Cap Quality Value ETF 0.18% Jun 30, 2026 Equity \n SYZ Lazard US Systematic Small Cap Equity ETF 0.17% Jun 30, 2026 Equity \n FSCC Federated Hermes MDT Small Cap Core ETF 0.16% Aug 31, 2026 Equity \n ACSG American Century Small Cap Growth Insights ETF 0.15% Aug 31, 2026 Equity \n FAD First Trust Multi Cap Growth AlphaDEX Fund 0.15% Nov 3, 2026 Equity \n JPSE JPMorgan Diversified Return U.S. Small Cap Equity ETF 0.15% Nov 3, 2026 Equity \n IBBQ Invesco Nasdaq Biotechnology ETF 0.13% Nov 3, 2026 Equity \n VFMO Vanguard U.S. Momentum Factor ETF 0.10% Sep 30, 2026 Equity \n IBB iShares Biotechnology ETF 0.09% Nov 3, 2026 Equity \n AVSC Avantis U.S. Small Cap Equity ETF 0.08% Nov 2, 2026 Equity \n RESM Columbia Research Enhanced Small Cap ETF 0.04% Jun 30, 2026 Equity \n IWO iShares Russell 2000 Growth ETF 0.04% Nov 3, 2026 Equity \n GSSC GS ActiveBeta U.S. Small Cap Equity ETF 0.04% Aug 31, 2026 Equity \n VTWG Vanguard Russell 2000 Growth ETF 0.04% Sep 30, 2026 Equity \n ISCG iShares Morningstar Small-Cap Growth ETF 0.03% Nov 3, 2026 Equity \n IWM iShares Russell 2000 ETF 0.03% Nov 3, 2026 Equity \n VTWO Vanguard Russell 2000 ETF 0.03% Sep 30, 2026 Equity \n RSSL Global X Russell 2000 ETF 0.02% Jul 31, 2026 Equity \n IWN iShares Russell 2000 Value ETF 0.02% Nov 3, 2026 Equity \n OMFS Invesco Russell 2000 Dynamic Multifactor ETF 0.02% Nov 3, 2026 Equity \n PRFZ Invesco RAFI US 1500 Small-Mid ETF 0.02% Nov 3, 2026 Equity \n SCHA Schwab U.S. Small-Cap ETF 0.02% Aug 31, 2026 Equity \n VTWV Vanguard Russell 2000 Value ETF 0.02% Sep 30, 2026 Equity \n ISCB 0.01% Jul 31, 2026 Equity \n MSML iShares MSCI USA Small-Cap ETF 0.01% Nov 3, 2026 Equity \n VXF Vanguard Extended Market ETF 0.01% Sep 30, 2026 Equity \n WSML iShares MSCI World Small-Cap ETF 0.01% Nov 3, 2026 Equity \n VHT Vanguard Health Care ETF 0.01% Sep 30, 2026 Equity \n ONEQ Fidelity Nasdaq Composite Index ETF 0.01% Aug 31, 2026 Equity \n FHLC Fidelity MSCI Health Care Index ETF 0.01% Jul 31, 2026 Equity \n MSSM Morgan Stanley Pathway Small-Mid Cap Equity ETF Aug 31, 2026 Equity \n DFAS U.S. Small Cap Portfolio: ETF Class Shares Jul 31, 2026 Equity \n VTI Vanguard Morningstar Total Stock Market ETF Sep 30, 2026 Equity \n DFAU Dimensional US Core Equity Market ETF Jul 31, 2026 Equity \n SCHB Schwab U.S. Broad Market ETF Aug 31, 2026 Equity \n VTHR Vanguard Russell 3000 ETF Sep 30, 2026 Equity \n Income and other funds that hold it\n Fund Name Share of the fund Holdings filed Category \n ITWO ProShares Russell 2000 High Income ETF 0.02% Aug 31, 2026 Income \n What this counts\n Septerna Inc (ticker SEPN, listed in US) is matched in every holdings book ETFIQ publishes, by its ticker and name. A share of the fund is the weight its issuer published, as of the Holdings filed date. Shares, preferred shares and debt are told by each fund\u2019s N-PORT asset type. A fund holding only the company\u2019s debt or preferred shares is listed under them, not counted as holding its shares. Options, swaps, futures and cash do not count as holding a company: a call option on a share is not the share. Funds whose book is gross exposure, not a portfolio, are left out.\n Each row shows the date the fund last filed.\n Look up another company .\n Questions people ask\n Which ETFs hold Septerna Inc? 43 thematic and core ETFs hold Septerna Inc, by holdings dated Jun 30, 2026 to Nov 3, 2026. The largest positions are XPH at 2.22% of the fund on Nov 3, 2026, FYC at 0.72% of the fund on Nov 3, 2026 and MMSC at 0.69% of the fund on Nov 3, 2026. 1 income and other fund on it is listed apart. \n Cite this page. ETFIQ, ETFs holding Septerna Inc, data as of Nov 5, 2026. https://etfiq.com/holdings/sepn/ Free to use with attribution for data ETFIQ computes; issuer data stays under its owner's terms. The underlying files are at Open data .\n Other forms Plain ETFIQ, ETFs holding Septerna Inc, data as of Nov 5, 2026. https://etfiq.com/holdings/sepn/ APA ETFIQ. (Nov 5, 2026). ETFs holding Septerna Inc. Retrieved from https://etfiq.com/holdings/sepn/ Markdown [ETFs holding Septerna Inc (ETFIQ, Nov 5, 2026)](https://etfiq.com/holdings/sepn/)","source":"ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.","publisher":{"@id":"https://etfiq.com/#org","name":"ETFIQ","url":"https://etfiq.com"},"license":"https://etfiq.com/license/","license_text":"Data ETFIQ computes is free to use with attribution: ETFIQ (etfiq.com). Issuer data stays under its owner's terms.","citation":"ETFIQ, ETFs holding Septerna Inc, data as of Nov 5, 2026. https://etfiq.com/holdings/sepn/"}