# SBIO (ALPS Medical Breakthroughs ETF)

ALPS · Stock ETFs · Health care · data as of Oct 2, 2026

SBIO tracks an index and returned +43.9% over the past year.

## Key facts

- SBIO, total return, 1 year: +43.9%, as of Oct 2, 2026.
- SBIO, expense ratio: 0.50%, as of Oct 2, 2026.
- SBIO, holdings: 82, as of Oct 2, 2026.
- SBIO, below its high: −20.7%, as of Oct 2, 2026.
- SBIO, net assets: $162m (SEC filing, whole fund, as filed for May 31, 2026).

## SBIO over each window to Oct 2, 2026

| Window | Total return | S&P 500 | Gap to S&P 500 | Gap to Nasdaq-100 |
| --- | --- | --- | --- | --- |
| 3 months | −13.5% | +3.6% | −17.1 pts | −18.8 pts |
| 6 months | +5.0% | +17.9% | −13.0 pts | −23.4 pts |
| 1 year | +43.9% | +16.2% | +27.7 pts | +19.6 pts |
| 3 years | +122.4% | +89.3% | +33.1 pts | +7.6 pts |
| Since listing | +145.7% | +354.8% | −209.1 pts | −546.6 pts |

## Every published field

| Field | Value | Source |
| --- | --- | --- |
| What it tracks | not read by ETFIQ | ETFIQ |
| Fund type | Equity fund | ETFIQ |
| Category | Stocks · Health care | ETFIQ |
| Expense ratio | 0.50% | 485BPOS XBRL, Mar 30, 2026 |
| Price | $56.15 | ETFIQ |
| Listed since | Dec 31, 2014 | ETFIQ |
| Net assets | $162m | SEC filing, whole fund, as filed for May 31, 2026 |
| Below its high | −20.7% | ETFIQ |
| Holdings | 82 | ETFIQ |
| Top ten weight | 34.8% | ETFIQ |
| Holdings as of | May 31, 2026 | SEC N-PORT |
| Already in the S&P 500, by weight | 0.0% | ETFIQ |
| Active share vs the S&P 500 | 100.0% | ETFIQ |
| Already in the Nasdaq-100, by weight | 0.0% | ETFIQ |

## Questions

### How has SBIO performed?

Over the year to Oct 2, 2026, SBIO returned +43.9% with distributions reinvested, against +16.2% for the S&P 500. Over three years the figure is +122.4%.

### What does SBIO cost?

The prospectus expense ratio is 0.50% a year.

### What does SBIO hold?

82 positions as filed for May 31, 2026, with the top ten at 34.8% of the fund. 0% of its weight is in stocks the S&P 500 also holds.

### How far is SBIO below its high?

20.7% below its high of Aug 19, 2026, measured on the reinvested series to Oct 2, 2026.


## Cite this page

ETFIQ, SBIO, data as of Oct 2, 2026. https://etfiq.com/funds/sbio
Free to use with attribution; the underlying files are at https://etfiq.com/data/.

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