# HELX (Franklin Genomic Advancements ETF)

Franklin · Thematic ETFs · data as of Sep 11, 2026

HELX holds 61 stocks, and 85% of its weight is outside the S&P 500.

## Key facts

- HELX, already in the S&P 500: 15.1%, as of Sep 11, 2026.
- HELX, active share vs the S&P 500: 97.2%, as of Sep 11, 2026.
- HELX, top ten holdings: 47.7%, as of Sep 11, 2026.
- HELX, total return, 1 year: +33.6%, as of Sep 11, 2026.
- HELX, net assets: $31m (issuer page, as of Sep 11, 2026).
- HELX, expense ratio: 0.50% (485BPOS XBRL, Jul 27, 2026).

## HELX over each window to Sep 11, 2026

| Window | Total return | S&P 500 | Gap to S&P 500 | Gap to Nasdaq-100 |
| --- | --- | --- | --- | --- |
| 3 months | +15.6% | +3.3% | +12.3 pts | +16.4 pts |
| 6 months | +28.1% | +16.0% | +12.1 pts | +7.5 pts |
| 1 year | +33.6% | +17.5% | +16.1 pts | +10.7 pts |
| 3 years | +38.7% | +77.9% | −39.2 pts | −56.4 pts |
| Since launch | +72.4% | +182.0% | −109.6 pts | −189.2 pts |

## Every published field

| Field | Value | Source |
| --- | --- | --- |
| Theme | Healthcare innovation and GLP-1 | ETFIQ, editorial |
| Launched | Feb 27, 2020 | ETFIQ |
| Already in the S&P 500, by weight | 15.1% | ETFIQ |
| Active share vs the S&P 500 | 97.2% | ETFIQ |
| Already in the Nasdaq-100, by weight | 10.0% | ETFIQ |
| Active share vs the Nasdaq-100 | 98.5% | ETFIQ |
| Top ten holdings weight | 47.7% | ETFIQ |
| Holdings | 61 | ETFIQ |
| Holdings as of | Jun 30, 2026 | SEC N-PORT |
| Top holdings | GUARDANT HEALTH INC 9.2%, NATERA INC 7.6%, KRYSTAL BIOTECH INC 6.4%, LIGAND PHARMACEUTICALS INC 4.7%, ADAPTIVE BIOTECHNOLOGIES CORP 4.0%, UNITED THERAPEUTICS CORP 3.5%, BRIDGEBIO PHARMA INC 3.5%, ELI LILLY & COMPANY 3.0%, TWIST BIOSCIENCE CORP 2.9%, VERTEX PHARMACEUTICALS INC 2.8% | ETFIQ |
| Net assets | $31m | issuer page, as of Sep 11, 2026 |
| Below its all-time high | −29.2% | ETFIQ |
| Expense ratio | 0.50% | 485BPOS XBRL, Jul 27, 2026 |
| Fee for the part that differs from the S&P 500, active expense ratio | 0.51% | ETFIQ |
| Closest funds by holdings overlap | WDNA 34%, GNOM 29%, HTEC 28%, IBBQ 26%, BBH 25% | ETFIQ |

## Questions

### How much of HELX is in S&P 500 companies?

By its holdings filed for Jun 30, 2026, 15% of HELX by weight is stocks the S&P 500 already holds. Its active share against the index is 97%, so that share is the part doing something different.

### What does HELX hold?

61 positions as filed for Jun 30, 2026, with the top ten at 48% of the fund. The largest are GUARDANT HEALTH INC at 9.2%, NATERA INC at 7.6%, KRYSTAL BIOTECH INC at 6.4%.

### Has HELX beaten the S&P 500?

Over the year to Sep 11, 2026 HELX returned +33.6% with distributions reinvested, against +17.5% for the S&P 500, so it finished ahead of the index by 16.1 points.

### What does HELX cost?

The prospectus expense ratio is 0.50% a year. Because 97% of the fund differs from the S&P 500, the fee on that differing part works out at 0.51%.


## Cite this page

ETFIQ, HELX, data as of Sep 11, 2026. https://etfiq.com/funds/helx
Free to use with attribution; the underlying files are at https://etfiq.com/data/.

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