# GNOM (Global X Genomics & Biotechnology ETF)

Global X · Thematic ETFs · data as of Sep 11, 2026

GNOM holds 50 stocks, and 78% of its weight is outside the S&P 500.

## Key facts

- GNOM, already in the S&P 500: 21.5%, as of Sep 11, 2026.
- GNOM, active share vs the S&P 500: 97.6%, as of Sep 11, 2026.
- GNOM, top ten holdings: 50.3%, as of Sep 11, 2026.
- GNOM, total return, 1 year: +69.7%, as of Sep 11, 2026.
- GNOM, net assets: $94m (the issuer own daily fund list, as of Sep 11, 2026).
- GNOM, expense ratio: 0.50% (485BPOS XBRL, Mar 27, 2026).

## GNOM over each window to Sep 11, 2026

| Window | Total return | S&P 500 | Gap to S&P 500 | Gap to Nasdaq-100 |
| --- | --- | --- | --- | --- |
| 3 months | +27.2% | +3.3% | +23.9 pts | +28.0 pts |
| 6 months | +44.0% | +16.0% | +28.0 pts | +23.3 pts |
| 1 year | +69.7% | +17.5% | +52.2 pts | +46.7 pts |
| 3 years | +43.7% | +77.9% | −34.2 pts | −51.4 pts |
| Since launch | +2.9% | +195.2% | −192.3 pts | −300.6 pts |

## Every published field

| Field | Value | Source |
| --- | --- | --- |
| Theme | Biotech and genomics | ETFIQ, editorial |
| Launched | Apr 10, 2019 | ETFIQ |
| Already in the S&P 500, by weight | 21.5% | ETFIQ |
| Active share vs the S&P 500 | 97.6% | ETFIQ |
| Already in the Nasdaq-100, by weight | 5.3% | ETFIQ |
| Active share vs the Nasdaq-100 | 98.8% | ETFIQ |
| Top ten holdings weight | 50.3% | ETFIQ |
| Holdings | 50 | ETFIQ |
| Holdings as of | Sep 11, 2026 | the issuer’s daily file |
| Top holdings | MODERNA INC 8.0%, 10X GENOMICS INC-CLASS A 6.2%, TWIST BIOSCIENCE CORP 6.0%, GUARDANT HEALTH INC 5.4%, NATERA INC 4.9%, ILLUMINA INC 4.9%, BIO-TECHNE CORP 3.8%, GENSCRIPT BIOTECH CORP 3.8%, BIOMARIN PHARMACEUTICAL INC 3.7%, VERTEX PHARMACEUTICALS INC 3.6% | ETFIQ |
| Net assets | $94m | the issuer own daily fund list, as of Sep 11, 2026 |
| Below its all-time high | −43.4% | ETFIQ |
| Expense ratio | 0.50% | 485BPOS XBRL, Mar 27, 2026 |
| Fee for the part that differs from the S&P 500, active expense ratio | 0.51% | ETFIQ |
| Closest funds by holdings overlap | ARKG 40%, WDNA 35%, PBE 29%, HELX 29%, IDNA 26% | ETFIQ |

## Questions

### How much of GNOM is in S&P 500 companies?

By its holdings published by its issuer for Sep 11, 2026, 22% of GNOM by weight is stocks the S&P 500 already holds. Its active share against the index is 98%, so that share is the part doing something different.

### What does GNOM hold?

50 positions as published by its issuer for Sep 11, 2026, with the top ten at 50% of the fund. The largest are MODERNA INC at 8.0%, 10X GENOMICS INC-CLASS A at 6.2%, TWIST BIOSCIENCE CORP at 6.0%.

### Has GNOM beaten the S&P 500?

Over the year to Sep 11, 2026 GNOM returned +69.7% with distributions reinvested, against +17.5% for the S&P 500, so it finished ahead of the index by 52.2 points.

### What does GNOM cost?

The prospectus expense ratio is 0.50% a year. Because 98% of the fund differs from the S&P 500, the fee on that differing part works out at 0.51%.


## Cite this page

ETFIQ, GNOM, data as of Sep 11, 2026. https://etfiq.com/funds/gnom
Free to use with attribution; the underlying files are at https://etfiq.com/data/.

HTML: https://etfiq.com/funds/gnom  ·  JSON: https://etfiq.com/funds/gnom.json