# FMED (Fidelity Disruptive Medicine ETF)

Fidelity · Thematic ETFs · data as of Sep 11, 2026

FMED holds 68 stocks, and 75% of its weight is outside the S&P 500.

## Key facts

- FMED, already in the S&P 500: 25.4%, as of Sep 11, 2026.
- FMED, active share vs the S&P 500: 97.1%, as of Sep 11, 2026.
- FMED, top ten holdings: 31.5%, as of Sep 11, 2026.
- FMED, total return, 1 year: +24.6%, as of Sep 11, 2026.
- FMED, net assets: $52m (the issuer own figure for this ETF, month end, as of Aug 31, 2026).
- FMED, expense ratio: 0.50% (485BPOS XBRL, Sep 24, 2025).

## FMED over each window to Sep 11, 2026

| Window | Total return | S&P 500 | Gap to S&P 500 | Gap to Nasdaq-100 |
| --- | --- | --- | --- | --- |
| 3 months | +21.4% | +3.3% | +18.1 pts | +22.2 pts |
| 6 months | +28.9% | +16.0% | +12.8 pts | +8.2 pts |
| 1 year | +24.6% | +17.5% | +7.1 pts | +1.6 pts |
| 3 years | +33.2% | +77.9% | −44.7 pts | −61.9 pts |
| Since launch | +23.2% | +83.6% | −60.4 pts | −78.8 pts |

## Every published field

| Field | Value | Source |
| --- | --- | --- |
| Theme | Broad innovation and megatrends | ETFIQ, editorial |
| Launched | Jun 12, 2023 | ETFIQ |
| Already in the S&P 500, by weight | 25.4% | ETFIQ |
| Active share vs the S&P 500 | 97.1% | ETFIQ |
| Already in the Nasdaq-100, by weight | 8.7% | ETFIQ |
| Active share vs the Nasdaq-100 | 98.9% | ETFIQ |
| Top ten holdings weight | 31.5% | ETFIQ |
| Holdings | 68 | ETFIQ |
| Holdings as of | May 31, 2026 | SEC N-PORT |
| Top holdings | UCB SA 4.8%, LIFESTANCE HEALTH GROUP INC 4.3%, DANAHER CORP 3.4%, 10X GENOMICS INC 3.1%, INTUITIVE SURGICAL INC 2.9%, COGENT BIOSCIENCES INC 2.9%, ALNYLAM PHARMACEUTICALS INC 2.8%, ARGENX SE 2.8%, LEGEND BIOTECH CORP 2.3%, UNITEDHEALTH GROUP INC 2.3% | ETFIQ |
| Net assets | $52m | the issuer own figure for this ETF, month end, as of Aug 31, 2026 |
| Below its all-time high | −5.7% | ETFIQ |
| Expense ratio | 0.50% | 485BPOS XBRL, Sep 24, 2025 |
| Fee for the part that differs from the S&P 500, active expense ratio | 0.51% | ETFIQ |
| Closest funds by holdings overlap | GDOC 24%, HTEC 22%, EKG 22%, IBBQ 20%, BMED 20% | ETFIQ |

## Questions

### How much of FMED is in S&P 500 companies?

By its holdings filed for May 31, 2026, 25% of FMED by weight is stocks the S&P 500 already holds. Its active share against the index is 97%, so that share is the part doing something different.

### What does FMED hold?

68 positions as filed for May 31, 2026, with the top ten at 32% of the fund. The largest are UCB SA at 4.8%, LIFESTANCE HEALTH GROUP INC at 4.3%, DANAHER CORP at 3.4%.

### Has FMED beaten the S&P 500?

Over the year to Sep 11, 2026 FMED returned +24.6% with distributions reinvested, against +17.5% for the S&P 500, so it finished ahead of the index by 7.1 points.

### What does FMED cost?

The prospectus expense ratio is 0.50% a year. Because 97% of the fund differs from the S&P 500, the fee on that differing part works out at 0.51%.


## Cite this page

ETFIQ, FMED, data as of Sep 11, 2026. https://etfiq.com/funds/fmed
Free to use with attribution; the underlying files are at https://etfiq.com/data/.

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