# WDNA (WisdomTree BioRevolution Fund)

WisdomTree · Thematic ETFs · data as of Sep 11, 2026

WDNA holds 80 stocks, and 74% of its weight is outside the S&P 500.

## Key facts

- WDNA, already in the S&P 500: 25.9%, as of Sep 11, 2026.
- WDNA, active share vs the S&P 500: 95.3%, as of Sep 11, 2026.
- WDNA, top ten holdings: 30.7%, as of Sep 11, 2026.
- WDNA, total return, 1 year: +56.1%, as of Sep 11, 2026.
- WDNA, net assets: $3m (SEC filing, whole fund, as filed for Jun 30, 2026).
- WDNA, expense ratio: 0.45% (485BPOS XBRL, Oct 28, 2025).

## WDNA over each window to Sep 11, 2026

| Window | Total return | S&P 500 | Gap to S&P 500 | Gap to Nasdaq-100 |
| --- | --- | --- | --- | --- |
| 3 months | +22.9% | +3.3% | +19.6 pts | +23.7 pts |
| 6 months | +29.6% | +16.0% | +13.6 pts | +8.9 pts |
| 1 year | +56.1% | +17.5% | +38.6 pts | +33.2 pts |
| 3 years | +44.0% | +77.9% | −33.9 pts | −51.1 pts |
| Since launch | −5.5% | +96.0% | −101.5 pts | −129.0 pts |

## Every published field

| Field | Value | Source |
| --- | --- | --- |
| Theme | Healthcare innovation and GLP-1 | ETFIQ, editorial |
| Launched | Jun 3, 2021 | ETFIQ |
| Already in the S&P 500, by weight | 25.9% | ETFIQ |
| Active share vs the S&P 500 | 95.3% | ETFIQ |
| Already in the Nasdaq-100, by weight | 5.8% | ETFIQ |
| Active share vs the Nasdaq-100 | 97.4% | ETFIQ |
| Top ten holdings weight | 30.7% | ETFIQ |
| Holdings | 80 | ETFIQ |
| Holdings as of | Jun 30, 2026 | SEC N-PORT |
| Top holdings | TWIST BIOSCIENCE CORP 6.0%, MODERNA INC 4.2%, ELI LILLY & COMPANY 4.1%, JOHNSON & JOHNSON 3.0%, UNITED THERAPEUTICS CORP 2.5%, NATERA INC 2.3%, TEMPUS AI INC 2.3%, IMMUNOME INC 2.3%, STRUCTURE THERAPEUTICS INC 2.1%, STOKE THERAPEUTICS INC 2.1% | ETFIQ |
| Net assets | $3m | SEC filing, whole fund, as filed for Jun 30, 2026 |
| Below its all-time high | −15.5% | ETFIQ |
| Expense ratio | 0.45% | 485BPOS XBRL, Oct 28, 2025 |
| Fee for the part that differs from the S&P 500, active expense ratio | 0.47% | ETFIQ |
| Closest funds by holdings overlap | GNOM 35%, HELX 34%, IBBQ 28%, ARKG 27%, BBP 26% | ETFIQ |

## Questions

### How much of WDNA is in S&P 500 companies?

By its holdings filed for Jun 30, 2026, 26% of WDNA by weight is stocks the S&P 500 already holds. Its active share against the index is 95%, so that share is the part doing something different.

### What does WDNA hold?

80 positions as filed for Jun 30, 2026, with the top ten at 31% of the fund. The largest are TWIST BIOSCIENCE CORP at 6.0%, MODERNA INC at 4.2%, ELI LILLY & COMPANY at 4.1%.

### Has WDNA beaten the S&P 500?

Over the year to Sep 11, 2026 WDNA returned +56.1% with distributions reinvested, against +17.5% for the S&P 500, so it finished ahead of the index by 38.6 points.

### What does WDNA cost?

The prospectus expense ratio is 0.45% a year. Because 95% of the fund differs from the S&P 500, the fee on that differing part works out at 0.47%.


## Cite this page

ETFIQ, WDNA, data as of Sep 11, 2026. https://etfiq.com/funds/WDNA
Free to use with attribution; the underlying files are at https://etfiq.com/data/.

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