# IBRN (iShares Neuroscience and Healthcare ETF)

iShares · Thematic ETFs · data as of Sep 11, 2026

IBRN holds 73 stocks, and 96% of its weight is outside the S&P 500.

## Key facts

- IBRN, already in the S&P 500: 4.3%, as of Sep 11, 2026.
- IBRN, active share vs the S&P 500: 100.0%, as of Sep 11, 2026.
- IBRN, top ten holdings: 45.7%, as of Sep 11, 2026.
- IBRN, total return, 1 year: +45.9%, as of Sep 11, 2026.
- IBRN, net assets: $5m (SEC filing, whole fund, as filed for Apr 30, 2026).
- IBRN, expense ratio: 0.47% (485BPOS XBRL, Nov 21, 2025).

## IBRN over each window to Sep 11, 2026

| Window | Total return | S&P 500 | Gap to S&P 500 | Gap to Nasdaq-100 |
| --- | --- | --- | --- | --- |
| 3 months | +7.4% | +3.3% | +4.1 pts | +8.2 pts |
| 6 months | +20.7% | +16.0% | +4.7 pts | 0.0 pts |
| 1 year | +45.9% | +17.5% | +28.4 pts | +22.9 pts |
| 3 years | +66.3% | +77.9% | −11.6 pts | −28.8 pts |
| Since launch | +54.5% | +99.0% | −44.4 pts | −83.7 pts |

## Every published field

| Field | Value | Source |
| --- | --- | --- |
| Theme | Therapeutics and medical devices | ETFIQ, editorial |
| Launched | Aug 26, 2022 | ETFIQ |
| Already in the S&P 500, by weight | 4.3% | ETFIQ |
| Active share vs the S&P 500 | 100.0% | ETFIQ |
| Already in the Nasdaq-100, by weight | 0.0% | ETFIQ |
| Active share vs the Nasdaq-100 | 100.0% | ETFIQ |
| Top ten holdings weight | 45.7% | ETFIQ |
| Holdings | 73 | ETFIQ |
| Holdings as of | Sep 10, 2026 | the issuer’s daily file |
| Top holdings | PRAXIS PRECISION MEDICINES 5.2%, DIANTHUS THERAPEUTICS INC 5.0%, SCHOLAR ROCK HOLDING 4.9%, ACADIA PHARMACEUTICALS 4.9%, XENON PHARMACEUTICALS 4.5%, ARROWHEAD PHARMACEUTICALS 4.5%, ARGENX SE ADR 4.3%, BIOGEN 4.3%, ALKERMES 4.2%, NEUROCRINE BIOSCIENCES 3.8% | ETFIQ |
| Net assets | $5m | SEC filing, whole fund, as filed for Apr 30, 2026 |
| Below its all-time high | −8.0% | ETFIQ |
| Expense ratio | 0.47% | 485BPOS XBRL, Nov 21, 2025 |
| Fee for the part that differs from the S&P 500, active expense ratio | 0.47% | ETFIQ |
| Closest funds by holdings overlap | FBT 18%, PBE 15%, PSIL 12%, IBBQ 11%, BBP 11% | ETFIQ |

## Questions

### How much of IBRN is in S&P 500 companies?

By its holdings published by its issuer for Sep 10, 2026, 4% of IBRN by weight is stocks the S&P 500 already holds. Its active share against the index is 100%, so that share is the part doing something different.

### What does IBRN hold?

73 positions as published by its issuer for Sep 10, 2026, with the top ten at 46% of the fund. The largest are PRAXIS PRECISION MEDICINES at 5.2%, DIANTHUS THERAPEUTICS INC at 5.0%, SCHOLAR ROCK HOLDING at 4.9%.

### Has IBRN beaten the S&P 500?

Over the year to Sep 11, 2026 IBRN returned +45.9% with distributions reinvested, against +17.5% for the S&P 500, so it finished ahead of the index by 28.4 points.

### What does IBRN cost?

The prospectus expense ratio is 0.47% a year. Because 100% of the fund differs from the S&P 500, the fee on that differing part works out at 0.47%.


## Cite this page

ETFIQ, IBRN, data as of Sep 11, 2026. https://etfiq.com/funds/IBRN
Free to use with attribution; the underlying files are at https://etfiq.com/data/.

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