{"url":"https://etfiq.com/compare/themes/canc-vs-mdev","section":"compare","title":"CANC vs MDEV: which is really different? | ETFIQ","description":"22.2% of CANC and 47.3% of MDEV is already in the S&P 500 by weight, as filed, and 0% of the two books are the same names at the same weight.","as_of":"Sep 30, 2026","structured_data":[{"@type":"FAQPage","mainEntity":[{"@type":"Question","name":"Do CANC and MDEV hold the same stocks?","acceptedAnswer":{"@type":"Answer","text":"By their latest filings, 0% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share."}},{"@type":"Question","name":"Which is more different from the S&P 500, CANC or MDEV?","acceptedAnswer":{"@type":"Answer","text":"CANC has 22% of its weight in S&P 500 names and MDEV has 47%, so MDEV differs more from the index."}},{"@type":"Question","name":"Which is cheaper, CANC or MDEV?","acceptedAnswer":{"@type":"Answer","text":"CANC charges 0.75% a year and MDEV charges 0.70%, so MDEV is cheaper. Fees come from each fund's prospectus."}}]},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"ETFIQ","item":"https://etfiq.com/"},{"@type":"ListItem","position":2,"name":"Thematic ETFs","item":"https://etfiq.com/themes/"},{"@type":"ListItem","position":3,"name":"CANC vs MDEV","item":"https://etfiq.com/compare/themes/canc-vs-mdev"}]},{"@type":"WebPage","name":"CANC vs MDEV: which is really different?","description":"22.2% of CANC and 47.3% of MDEV is already in the S&P 500 by weight, as filed, and 0% of the two books are the same names at the same weight. Returns and overlap to Sep 30, 2026.","url":"https://etfiq.com/compare/themes/canc-vs-mdev","dateModified":"2026-09-30","abstract":"CANC and MDEV hold 0% of their weight in the same names, and CANC returned +46.5% over the year.","publisher":{"@id":"https://etfiq.com/#org"},"isPartOf":{"@id":"https://etfiq.com/#website"},"speakable":{"@type":"SpeakableSpecification","cssSelector":[".verdict",".faq"]}},{"@type":"Dataset","name":"ETFIQ comparison of CANC and MDEV","description":"22.2% of CANC and 47.3% of MDEV is already in the S&P 500 by weight, as filed, and 0% of the two books are the same names at the same weight. Returns and overlap to Sep 30, 2026.","dateModified":"2026-09-30","creator":{"@id":"https://etfiq.com/#org"},"isAccessibleForFree":true,"url":"https://etfiq.com/compare/themes/canc-vs-mdev","license":"https://etfiq.com/standards/","publisher":{"@id":"https://etfiq.com/#org"},"inLanguage":"en","creativeWorkStatus":"Published","distribution":[{"@type":"DataDownload","encodingFormat":"application/json","contentUrl":"https://etfiq.com/data/thematic.json"}],"variableMeasured":["Weight overlap with the S&P 500","Active share","Holdings","Top ten share of the fund","Total return","Fee for the differing part","Expense ratio"],"keywords":["exchange-traded funds","ETF","Thematic ETFs","fund data","SEC filings"]}],"characters":6596,"truncated":true,"content":"ETFIQ / Thematic ETFs / Head to head / CANC vs MDEV \n ETFIQ etfiq.com \u00b7 independent ETF data \n\n Data as of Sep 30, 2026 .\n\n CANC vs MDEV: which is really different?\n\n CANC and MDEV hold 0% of their weight in the same names, and CANC returned +46.5% over the year.\n Copy this for sharing \n \n Tema Oncology ETF and First Trust Indxx Medical Devices ETF.\n\n Download as PDF \n\n 22.2% CANC in the S&P 500 \n 47.3% MDEV in the S&P 500 \n +46.5% CANC total return, 1 year \n +4.1% MDEV total return, 1 year \n\n ETFIQ Off-Index Score: MDEV scores higher\n How much of it is not the index it is sold as an alternati","source":"ETFIQ, independent ETF data. Recomputed nightly from public filings and prices.","publisher":{"@id":"https://etfiq.com/#org","name":"ETFIQ","url":"https://etfiq.com"},"license":"https://etfiq.com/license/","citation":"ETFIQ, as of Sep 30, 2026. https://etfiq.com/compare/themes/canc-vs-mdev","a":{"ticker":"CANC","name":"Tema Oncology ETF","issuer":"Tema","desk":"themes","as_of":"2026-09-30","verdict":"CANC holds 58 stocks, and 78% of its weight is outside the S&P 500.","url":"https://etfiq.com/funds/canc","key_facts":[{"label":"Already in the S&P 500","value":"22.2%","as_of":"2026-09-30","source":null},{"label":"Active share vs the S&P 500","value":"95.6%","as_of":"2026-09-30","source":null},{"label":"Top ten holdings","value":"40.1%","as_of":"2026-09-30","source":null},{"label":"Total return, 1 year","value":"+46.5%","as_of":"2026-09-30","source":null},{"label":"Net assets","value":"$209m","as_of":"2026-09-30","source":"issuer page, as of Sep 30, 2026"},{"label":"Expense ratio","value":"0.75%","as_of":"2026-09-30","source":"485BPOS XBRL, Jun 29, 2026"}]},"b":{"ticker":"MDEV","name":"First Trust Indxx Medical Devices ETF","issuer":"First Trust","desk":"themes","as_of":"2026-09-30","verdict":"MDEV holds 54 stocks, and 53% of its weight is outside the S&P 500.","url":"https://etfiq.com/funds/mdev","key_facts":[{"label":"Already in the S&P 500","value":"47.3%","as_of":"2026-09-30","source":null},{"label":"Active share vs the S&P 500","value":"98.0%","as_of":"2026-09-30","source":null},{"label":"Top ten holdings","value":"27.6%","as_of":"2026-09-30","source":null},{"label":"Total return, 1 year","value":"+4.1%","as_of":"2026-09-30","source":null},{"label":"Net assets","value":"$3m","as_of":"2026-09-30","source":"issuer page, as of Sep 30, 2026"},{"label":"Expense ratio","value":"0.70%","as_of":"2026-09-30","source":"485BPOS XBRL, Jul 29, 2026"}]},"overlap_pct":0,"full_text_at":"https://etfiq.com/compare/themes/canc-vs-mdev"}